Pulmonary parenchymal involvement caused by Tropheryma whipplei
We report a 26-year-old man with left chest pain for 4 days. His chest CT showed a cavity in the left upper lung. Tuberculosis was suspected first, but metagenomics next generation sequencing (mNGS) in bronchoalveolar lavage fluid only detected Tropheryma whipplei. Tropheryma whipplei is the pathoge...
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De Gruyter
2021
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oai:doaj.org-article:b9cc2e07b6d349eda9417e5e64f5852b2021-12-05T14:10:54ZPulmonary parenchymal involvement caused by Tropheryma whipplei2391-546310.1515/med-2021-0297https://doaj.org/article/b9cc2e07b6d349eda9417e5e64f5852b2021-06-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0297https://doaj.org/toc/2391-5463We report a 26-year-old man with left chest pain for 4 days. His chest CT showed a cavity in the left upper lung. Tuberculosis was suspected first, but metagenomics next generation sequencing (mNGS) in bronchoalveolar lavage fluid only detected Tropheryma whipplei. Tropheryma whipplei is the pathogen of Whipple’s disease. The most frequently involved organs are the eyes, heart, and central nervous system. Pulmonary parenchymal involvement is rare. To our knowledge, this is the first reported case of pulmonary cavity caused by Tropheryma whipplei. Nineteen cases of pulmonary parenchymal involvement were found by literature search. The most common respiratory symptom was cough, followed by dyspnea/breathlessness and chest pain. The most common finding in chest imaging was pulmonary nodules, followed by interstitial changes and patchy infiltration. Our case and literature review highlighted that Tropheryma whipplei infection should be considered in the differential diagnosis of pulmonary cavity, pulmonary nodules, interstitial changes, and patchy infiltration. mNGS is helpful to improve diagnosis rate.Zhang Wen MeiXu LingDe Gruyterarticlewhipple’s diseasetropheryma whippleipulmonarycavityMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 843-846 (2021) |
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whipple’s disease tropheryma whipplei pulmonary cavity Medicine R |
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whipple’s disease tropheryma whipplei pulmonary cavity Medicine R Zhang Wen Mei Xu Ling Pulmonary parenchymal involvement caused by Tropheryma whipplei |
description |
We report a 26-year-old man with left chest pain for 4 days. His chest CT showed a cavity in the left upper lung. Tuberculosis was suspected first, but metagenomics next generation sequencing (mNGS) in bronchoalveolar lavage fluid only detected Tropheryma whipplei. Tropheryma whipplei is the pathogen of Whipple’s disease. The most frequently involved organs are the eyes, heart, and central nervous system. Pulmonary parenchymal involvement is rare. To our knowledge, this is the first reported case of pulmonary cavity caused by Tropheryma whipplei. Nineteen cases of pulmonary parenchymal involvement were found by literature search. The most common respiratory symptom was cough, followed by dyspnea/breathlessness and chest pain. The most common finding in chest imaging was pulmonary nodules, followed by interstitial changes and patchy infiltration. Our case and literature review highlighted that Tropheryma whipplei infection should be considered in the differential diagnosis of pulmonary cavity, pulmonary nodules, interstitial changes, and patchy infiltration. mNGS is helpful to improve diagnosis rate. |
format |
article |
author |
Zhang Wen Mei Xu Ling |
author_facet |
Zhang Wen Mei Xu Ling |
author_sort |
Zhang Wen Mei |
title |
Pulmonary parenchymal involvement caused by Tropheryma whipplei |
title_short |
Pulmonary parenchymal involvement caused by Tropheryma whipplei |
title_full |
Pulmonary parenchymal involvement caused by Tropheryma whipplei |
title_fullStr |
Pulmonary parenchymal involvement caused by Tropheryma whipplei |
title_full_unstemmed |
Pulmonary parenchymal involvement caused by Tropheryma whipplei |
title_sort |
pulmonary parenchymal involvement caused by tropheryma whipplei |
publisher |
De Gruyter |
publishDate |
2021 |
url |
https://doaj.org/article/b9cc2e07b6d349eda9417e5e64f5852b |
work_keys_str_mv |
AT zhangwenmei pulmonaryparenchymalinvolvementcausedbytropherymawhipplei AT xuling pulmonaryparenchymalinvolvementcausedbytropherymawhipplei |
_version_ |
1718371624560885760 |