Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy

Qiangying Yi,1 Jin Ma,1 Ke Kang,1 Zhongwei Gu1,2 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 2College of Materials Science and Engineering, Nanjing Tech University, Nanjing, P.R. China Introduction: Increasing demands in precise control over delivery and fu...

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Autores principales:	Yi Q, Ma J, Kang K, Gu Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	drug delivery active targeting zwitterionic poly(carboxybetaine methacrylate) doxorubicin Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b9cc65e87b61452db98ae418c4b01a11
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spelling	oai:doaj.org-article:b9cc65e87b61452db98ae418c4b01a112021-12-02T01:23:33ZBioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy1178-2013https://doaj.org/article/b9cc65e87b61452db98ae418c4b01a112018-01-01T00:00:00Zhttps://www.dovepress.com/bioreducible-nanocapsules-for-folic-acid-assisted-targeting-and-effect-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Qiangying Yi,1 Jin Ma,1 Ke Kang,1 Zhongwei Gu1,2 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 2College of Materials Science and Engineering, Nanjing Tech University, Nanjing, P.R. China Introduction: Increasing demands in precise control over delivery and functionalization of therapeutic agents for tumor-specific chemotherapy have led to a rapid development in nanocarriers. Herein, we report a nanocapsule (NC) system for tumor-oriented drug delivery and effective tumor therapy.Materials and methods: Functionalized hyaluronan is utilized to build up the NC shells, in which bioreduction cleavable sites, targeting ligand folic acid (FA), and zwitterionic tentacles are integrated.Results: The hollow NCs obtained (~50 nm in diameter) showed well-defined spherical shell structures with a shell thickness of ~8 nm. These specially designed NCs (doxorubicin [DOX]/FA-Z-NCs) with high drug encapsulation content exhibited good biocompatibility in vitro and fast intracellular drug release behavior mediated by intracellular glutathione.Conclusion: Cellular uptake tests demonstrated rapid uptake of these functionalized NCs and effective escape from endosomes. Antitumor efficacy of the DOX/FA-Z-NCs was confirmed by the significant tumor growth inhibition effect as well as greatly reduced side effects, in contrast with those of the free drug DOX hydrochloride. Keywords: drug delivery, active targeting, zwitterionic poly(carboxybetaine methacrylate), doxorubicinYi QMa JKang KGu ZDove Medical Pressarticledrug deliveryactive targetingzwitterionic poly(carboxybetaine methacrylate)doxorubicinMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 653-667 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug delivery active targeting zwitterionic poly(carboxybetaine methacrylate) doxorubicin Medicine (General) R5-920
spellingShingle	drug delivery active targeting zwitterionic poly(carboxybetaine methacrylate) doxorubicin Medicine (General) R5-920 Yi Q Ma J Kang K Gu Z Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
description	Qiangying Yi,1 Jin Ma,1 Ke Kang,1 Zhongwei Gu1,2 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 2College of Materials Science and Engineering, Nanjing Tech University, Nanjing, P.R. China Introduction: Increasing demands in precise control over delivery and functionalization of therapeutic agents for tumor-specific chemotherapy have led to a rapid development in nanocarriers. Herein, we report a nanocapsule (NC) system for tumor-oriented drug delivery and effective tumor therapy.Materials and methods: Functionalized hyaluronan is utilized to build up the NC shells, in which bioreduction cleavable sites, targeting ligand folic acid (FA), and zwitterionic tentacles are integrated.Results: The hollow NCs obtained (~50 nm in diameter) showed well-defined spherical shell structures with a shell thickness of ~8 nm. These specially designed NCs (doxorubicin [DOX]/FA-Z-NCs) with high drug encapsulation content exhibited good biocompatibility in vitro and fast intracellular drug release behavior mediated by intracellular glutathione.Conclusion: Cellular uptake tests demonstrated rapid uptake of these functionalized NCs and effective escape from endosomes. Antitumor efficacy of the DOX/FA-Z-NCs was confirmed by the significant tumor growth inhibition effect as well as greatly reduced side effects, in contrast with those of the free drug DOX hydrochloride. Keywords: drug delivery, active targeting, zwitterionic poly(carboxybetaine methacrylate), doxorubicin
format	article
author	Yi Q Ma J Kang K Gu Z
author_facet	Yi Q Ma J Kang K Gu Z
author_sort	Yi Q
title	Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_short	Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_full	Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_fullStr	Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_full_unstemmed	Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_sort	bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/b9cc65e87b61452db98ae418c4b01a11
work_keys_str_mv	AT yiq bioreduciblenanocapsulesforfolicacidassistedtargetingandeffectivetumorspecificchemotherapy AT maj bioreduciblenanocapsulesforfolicacidassistedtargetingandeffectivetumorspecificchemotherapy AT kangk bioreduciblenanocapsulesforfolicacidassistedtargetingandeffectivetumorspecificchemotherapy AT guz bioreduciblenanocapsulesforfolicacidassistedtargetingandeffectivetumorspecificchemotherapy
_version_	1718403158439362560

Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy

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