FBXO22 degrades nuclear PTEN to promote tumorigenesis

Loss of nuclear PTEN is associated with aggressive cancers. Here the authors show that nuclear PTEN is more susceptible to ubiquitin-mediated proteasomal degradation than cytoplasmic PTEN, and identify FBXO22 ubiquitinates and degrades nuclear PTEN to promote tumorigenesis.

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Autores principales:	Meng-Kai Ge, Na Zhang, Li Xia, Cheng Zhang, Shuang-Shu Dong, Zhan-Ming Li, Yan Ji, Min-Hua Zheng, Jing Sun, Guo-Qiang Chen, Shao-Ming Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b9d4d4b889034e57b5dc632ab36c0c3f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:b9d4d4b889034e57b5dc632ab36c0c3f2021-12-02T17:33:12ZFBXO22 degrades nuclear PTEN to promote tumorigenesis10.1038/s41467-020-15578-12041-1723https://doaj.org/article/b9d4d4b889034e57b5dc632ab36c0c3f2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15578-1https://doaj.org/toc/2041-1723Loss of nuclear PTEN is associated with aggressive cancers. Here the authors show that nuclear PTEN is more susceptible to ubiquitin-mediated proteasomal degradation than cytoplasmic PTEN, and identify FBXO22 ubiquitinates and degrades nuclear PTEN to promote tumorigenesis.Meng-Kai GeNa ZhangLi XiaCheng ZhangShuang-Shu DongZhan-Ming LiYan JiMin-Hua ZhengJing SunGuo-Qiang ChenShao-Ming ShenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng-Kai Ge Na Zhang Li Xia Cheng Zhang Shuang-Shu Dong Zhan-Ming Li Yan Ji Min-Hua Zheng Jing Sun Guo-Qiang Chen Shao-Ming Shen FBXO22 degrades nuclear PTEN to promote tumorigenesis
description	Loss of nuclear PTEN is associated with aggressive cancers. Here the authors show that nuclear PTEN is more susceptible to ubiquitin-mediated proteasomal degradation than cytoplasmic PTEN, and identify FBXO22 ubiquitinates and degrades nuclear PTEN to promote tumorigenesis.
format	article
author	Meng-Kai Ge Na Zhang Li Xia Cheng Zhang Shuang-Shu Dong Zhan-Ming Li Yan Ji Min-Hua Zheng Jing Sun Guo-Qiang Chen Shao-Ming Shen
author_facet	Meng-Kai Ge Na Zhang Li Xia Cheng Zhang Shuang-Shu Dong Zhan-Ming Li Yan Ji Min-Hua Zheng Jing Sun Guo-Qiang Chen Shao-Ming Shen
author_sort	Meng-Kai Ge
title	FBXO22 degrades nuclear PTEN to promote tumorigenesis
title_short	FBXO22 degrades nuclear PTEN to promote tumorigenesis
title_full	FBXO22 degrades nuclear PTEN to promote tumorigenesis
title_fullStr	FBXO22 degrades nuclear PTEN to promote tumorigenesis
title_full_unstemmed	FBXO22 degrades nuclear PTEN to promote tumorigenesis
title_sort	fbxo22 degrades nuclear pten to promote tumorigenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b9d4d4b889034e57b5dc632ab36c0c3f
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FBXO22 degrades nuclear PTEN to promote tumorigenesis

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