Cortical feedback and gating in odor discrimination and generalization.

A central question in neuroscience is how context changes perception. In the olfactory system, for example, experiments show that task demands can drive divergence and convergence of cortical odor responses, likely underpinning olfactory discrimination and generalization. Here, we propose a simple s...

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Autores principales:	Gaia Tavoni, David E Chen Kersen, Vijay Balasubramanian
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b9d7f83aafa54bc1bffe8446a24732f7
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id	oai:doaj.org-article:b9d7f83aafa54bc1bffe8446a24732f7
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spelling	oai:doaj.org-article:b9d7f83aafa54bc1bffe8446a24732f72021-11-25T05:42:27ZCortical feedback and gating in odor discrimination and generalization.1553-734X1553-735810.1371/journal.pcbi.1009479https://doaj.org/article/b9d7f83aafa54bc1bffe8446a24732f72021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009479https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358A central question in neuroscience is how context changes perception. In the olfactory system, for example, experiments show that task demands can drive divergence and convergence of cortical odor responses, likely underpinning olfactory discrimination and generalization. Here, we propose a simple statistical mechanism for this effect based on unstructured feedback from the central brain to the olfactory bulb, which represents the context associated with an odor, and sufficiently selective cortical gating of sensory inputs. Strikingly, the model predicts that both convergence and divergence of cortical odor patterns should increase when odors are initially more similar, an effect reported in recent experiments. The theory in turn predicts reversals of these trends following experimental manipulations and in neurological conditions that increase cortical excitability.Gaia TavoniDavid E Chen KersenVijay BalasubramanianPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 10, p e1009479 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Gaia Tavoni David E Chen Kersen Vijay Balasubramanian Cortical feedback and gating in odor discrimination and generalization.
description	A central question in neuroscience is how context changes perception. In the olfactory system, for example, experiments show that task demands can drive divergence and convergence of cortical odor responses, likely underpinning olfactory discrimination and generalization. Here, we propose a simple statistical mechanism for this effect based on unstructured feedback from the central brain to the olfactory bulb, which represents the context associated with an odor, and sufficiently selective cortical gating of sensory inputs. Strikingly, the model predicts that both convergence and divergence of cortical odor patterns should increase when odors are initially more similar, an effect reported in recent experiments. The theory in turn predicts reversals of these trends following experimental manipulations and in neurological conditions that increase cortical excitability.
format	article
author	Gaia Tavoni David E Chen Kersen Vijay Balasubramanian
author_facet	Gaia Tavoni David E Chen Kersen Vijay Balasubramanian
author_sort	Gaia Tavoni
title	Cortical feedback and gating in odor discrimination and generalization.
title_short	Cortical feedback and gating in odor discrimination and generalization.
title_full	Cortical feedback and gating in odor discrimination and generalization.
title_fullStr	Cortical feedback and gating in odor discrimination and generalization.
title_full_unstemmed	Cortical feedback and gating in odor discrimination and generalization.
title_sort	cortical feedback and gating in odor discrimination and generalization.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b9d7f83aafa54bc1bffe8446a24732f7
work_keys_str_mv	AT gaiatavoni corticalfeedbackandgatinginodordiscriminationandgeneralization AT davidechenkersen corticalfeedbackandgatinginodordiscriminationandgeneralization AT vijaybalasubramanian corticalfeedbackandgatinginodordiscriminationandgeneralization
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Cortical feedback and gating in odor discrimination and generalization.

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