The telomere complex and the origin of the cancer stem cell

Abstract Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these events can by themselves trigger maligna...

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Autor principal: A. Torres-Montaner
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Lenguaje:EN
Publicado: BMC 2021
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Acceso en línea:https://doaj.org/article/b9d99a7caf15421fbad10efff3aadd3b
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spelling oai:doaj.org-article:b9d99a7caf15421fbad10efff3aadd3b2021-11-07T12:12:42ZThe telomere complex and the origin of the cancer stem cell10.1186/s40364-021-00339-z2050-7771https://doaj.org/article/b9d99a7caf15421fbad10efff3aadd3b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40364-021-00339-zhttps://doaj.org/toc/2050-7771Abstract Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these events can by themselves trigger malignant transformation. Activation of NFκB, the outcome of telomere complex damage, is present in leukemia stem cells but absent in normal stem cells and can activate DOT1L which has been linked to MLL-fusion leukemias. Tumors that arise from cells of early and late developmental stages appear to follow two different oncogenic routes in which the role of telomere and telomerase signaling might be differentially involved. In contrast, direct malignant transformation of stem cells appears to be extremely rare. This suggests an inherent resistance of stem cells to cancer transformation which could be linked to a stem cell’specific mechanism of telomere maintenance. However, tumor protection of normal stem cells could also be conferred by cell extrinsic mechanisms.A. Torres-MontanerBMCarticleEndoGTelomere biology disordersHematopoietic stem cellsTelomere-associated secretoy phenotype (TASP)Senescence-associated secretoy phenotype (SASP)Cell of cancer originTherapeutics. PharmacologyRM1-950ENBiomarker Research, Vol 9, Iss 1, Pp 1-30 (2021)
institution DOAJ
collection DOAJ
language EN
topic EndoG
Telomere biology disorders
Hematopoietic stem cells
Telomere-associated secretoy phenotype (TASP)
Senescence-associated secretoy phenotype (SASP)
Cell of cancer origin
Therapeutics. Pharmacology
RM1-950
spellingShingle EndoG
Telomere biology disorders
Hematopoietic stem cells
Telomere-associated secretoy phenotype (TASP)
Senescence-associated secretoy phenotype (SASP)
Cell of cancer origin
Therapeutics. Pharmacology
RM1-950
A. Torres-Montaner
The telomere complex and the origin of the cancer stem cell
description Abstract Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these events can by themselves trigger malignant transformation. Activation of NFκB, the outcome of telomere complex damage, is present in leukemia stem cells but absent in normal stem cells and can activate DOT1L which has been linked to MLL-fusion leukemias. Tumors that arise from cells of early and late developmental stages appear to follow two different oncogenic routes in which the role of telomere and telomerase signaling might be differentially involved. In contrast, direct malignant transformation of stem cells appears to be extremely rare. This suggests an inherent resistance of stem cells to cancer transformation which could be linked to a stem cell’specific mechanism of telomere maintenance. However, tumor protection of normal stem cells could also be conferred by cell extrinsic mechanisms.
format article
author A. Torres-Montaner
author_facet A. Torres-Montaner
author_sort A. Torres-Montaner
title The telomere complex and the origin of the cancer stem cell
title_short The telomere complex and the origin of the cancer stem cell
title_full The telomere complex and the origin of the cancer stem cell
title_fullStr The telomere complex and the origin of the cancer stem cell
title_full_unstemmed The telomere complex and the origin of the cancer stem cell
title_sort telomere complex and the origin of the cancer stem cell
publisher BMC
publishDate 2021
url https://doaj.org/article/b9d99a7caf15421fbad10efff3aadd3b
work_keys_str_mv AT atorresmontaner thetelomerecomplexandtheoriginofthecancerstemcell
AT atorresmontaner telomerecomplexandtheoriginofthecancerstemcell
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