The telomere complex and the origin of the cancer stem cell
Abstract Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these events can by themselves trigger maligna...
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oai:doaj.org-article:b9d99a7caf15421fbad10efff3aadd3b2021-11-07T12:12:42ZThe telomere complex and the origin of the cancer stem cell10.1186/s40364-021-00339-z2050-7771https://doaj.org/article/b9d99a7caf15421fbad10efff3aadd3b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40364-021-00339-zhttps://doaj.org/toc/2050-7771Abstract Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these events can by themselves trigger malignant transformation. Activation of NFκB, the outcome of telomere complex damage, is present in leukemia stem cells but absent in normal stem cells and can activate DOT1L which has been linked to MLL-fusion leukemias. Tumors that arise from cells of early and late developmental stages appear to follow two different oncogenic routes in which the role of telomere and telomerase signaling might be differentially involved. In contrast, direct malignant transformation of stem cells appears to be extremely rare. This suggests an inherent resistance of stem cells to cancer transformation which could be linked to a stem cell’specific mechanism of telomere maintenance. However, tumor protection of normal stem cells could also be conferred by cell extrinsic mechanisms.A. Torres-MontanerBMCarticleEndoGTelomere biology disordersHematopoietic stem cellsTelomere-associated secretoy phenotype (TASP)Senescence-associated secretoy phenotype (SASP)Cell of cancer originTherapeutics. PharmacologyRM1-950ENBiomarker Research, Vol 9, Iss 1, Pp 1-30 (2021) |
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EndoG Telomere biology disorders Hematopoietic stem cells Telomere-associated secretoy phenotype (TASP) Senescence-associated secretoy phenotype (SASP) Cell of cancer origin Therapeutics. Pharmacology RM1-950 |
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EndoG Telomere biology disorders Hematopoietic stem cells Telomere-associated secretoy phenotype (TASP) Senescence-associated secretoy phenotype (SASP) Cell of cancer origin Therapeutics. Pharmacology RM1-950 A. Torres-Montaner The telomere complex and the origin of the cancer stem cell |
description |
Abstract Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these events can by themselves trigger malignant transformation. Activation of NFκB, the outcome of telomere complex damage, is present in leukemia stem cells but absent in normal stem cells and can activate DOT1L which has been linked to MLL-fusion leukemias. Tumors that arise from cells of early and late developmental stages appear to follow two different oncogenic routes in which the role of telomere and telomerase signaling might be differentially involved. In contrast, direct malignant transformation of stem cells appears to be extremely rare. This suggests an inherent resistance of stem cells to cancer transformation which could be linked to a stem cell’specific mechanism of telomere maintenance. However, tumor protection of normal stem cells could also be conferred by cell extrinsic mechanisms. |
format |
article |
author |
A. Torres-Montaner |
author_facet |
A. Torres-Montaner |
author_sort |
A. Torres-Montaner |
title |
The telomere complex and the origin of the cancer stem cell |
title_short |
The telomere complex and the origin of the cancer stem cell |
title_full |
The telomere complex and the origin of the cancer stem cell |
title_fullStr |
The telomere complex and the origin of the cancer stem cell |
title_full_unstemmed |
The telomere complex and the origin of the cancer stem cell |
title_sort |
telomere complex and the origin of the cancer stem cell |
publisher |
BMC |
publishDate |
2021 |
url |
https://doaj.org/article/b9d99a7caf15421fbad10efff3aadd3b |
work_keys_str_mv |
AT atorresmontaner thetelomerecomplexandtheoriginofthecancerstemcell AT atorresmontaner telomerecomplexandtheoriginofthecancerstemcell |
_version_ |
1718443512479875072 |