Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis

Abstract The objective was to evaluate the effect of dietary Bacillus altitudinis spore supplementation during day (D)0–28 post-weaning (PW) and/or D29–56 PW compared with antibiotic and zinc oxide (AB + ZnO) supplementation on pig growth and gut microbiota. Eighty piglets were selected at weaning a...

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Autores principales:	Daniel Crespo-Piazuelo, Peadar G. Lawlor, Samir Ranjitkar, Paul Cormican, Carmen Villodre, Meike A. Bouwhuis, Alan Marsh, Fiona Crispie, Ruth Rattigan, Gillian E. Gardiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9de95a60928444faae110c2bca36f15
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spelling	oai:doaj.org-article:b9de95a60928444faae110c2bca36f152021-12-05T12:11:52ZIntestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis10.1038/s41598-021-01826-x2045-2322https://doaj.org/article/b9de95a60928444faae110c2bca36f152021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01826-xhttps://doaj.org/toc/2045-2322Abstract The objective was to evaluate the effect of dietary Bacillus altitudinis spore supplementation during day (D)0–28 post-weaning (PW) and/or D29–56 PW compared with antibiotic and zinc oxide (AB + ZnO) supplementation on pig growth and gut microbiota. Eighty piglets were selected at weaning and randomly assigned to one of five dietary treatments: (1) negative control (Con/Con); (2) probiotic spores from D29–56 PW (Con/Pro); (3) probiotic spores from D0–28 PW (Pro/Con); (4) probiotic spores from D0–56 PW (Pro/Pro) and (5) AB + ZnO from D0–28 PW. Overall, compared with the AB + ZnO group, the Pro/Con group had lower body weight, average daily gain and feed intake and the Pro/Pro group tended to have lower daily gain and feed intake. However, none of these parameters differed between any of the probiotic-treated groups and the Con/Con group. Overall, AB + ZnO-supplemented pigs had higher Bacteroidaceae and Prevotellaceae and lower Lactobacillaceae and Spirochaetaceae abundance compared to the Con/Con group, which may help to explain improvements in growth between D15–28 PW. The butyrate-producing genera Agathobacter, Faecalibacterium and Roseburia were more abundant in the Pro/Con group compared with the Con/Con group on D35 PW. Thus, whilst supplementation with B. altitudinis did not enhance pig growth performance, it did have a subtle, albeit potentially beneficial, impact on the intestinal microbiota.Daniel Crespo-PiazueloPeadar G. LawlorSamir RanjitkarPaul CormicanCarmen VillodreMeike A. BouwhuisAlan MarshFiona CrispieRuth RattiganGillian E. GardinerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Crespo-Piazuelo Peadar G. Lawlor Samir Ranjitkar Paul Cormican Carmen Villodre Meike A. Bouwhuis Alan Marsh Fiona Crispie Ruth Rattigan Gillian E. Gardiner Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis
description	Abstract The objective was to evaluate the effect of dietary Bacillus altitudinis spore supplementation during day (D)0–28 post-weaning (PW) and/or D29–56 PW compared with antibiotic and zinc oxide (AB + ZnO) supplementation on pig growth and gut microbiota. Eighty piglets were selected at weaning and randomly assigned to one of five dietary treatments: (1) negative control (Con/Con); (2) probiotic spores from D29–56 PW (Con/Pro); (3) probiotic spores from D0–28 PW (Pro/Con); (4) probiotic spores from D0–56 PW (Pro/Pro) and (5) AB + ZnO from D0–28 PW. Overall, compared with the AB + ZnO group, the Pro/Con group had lower body weight, average daily gain and feed intake and the Pro/Pro group tended to have lower daily gain and feed intake. However, none of these parameters differed between any of the probiotic-treated groups and the Con/Con group. Overall, AB + ZnO-supplemented pigs had higher Bacteroidaceae and Prevotellaceae and lower Lactobacillaceae and Spirochaetaceae abundance compared to the Con/Con group, which may help to explain improvements in growth between D15–28 PW. The butyrate-producing genera Agathobacter, Faecalibacterium and Roseburia were more abundant in the Pro/Con group compared with the Con/Con group on D35 PW. Thus, whilst supplementation with B. altitudinis did not enhance pig growth performance, it did have a subtle, albeit potentially beneficial, impact on the intestinal microbiota.
format	article
author	Daniel Crespo-Piazuelo Peadar G. Lawlor Samir Ranjitkar Paul Cormican Carmen Villodre Meike A. Bouwhuis Alan Marsh Fiona Crispie Ruth Rattigan Gillian E. Gardiner
author_facet	Daniel Crespo-Piazuelo Peadar G. Lawlor Samir Ranjitkar Paul Cormican Carmen Villodre Meike A. Bouwhuis Alan Marsh Fiona Crispie Ruth Rattigan Gillian E. Gardiner
author_sort	Daniel Crespo-Piazuelo
title	Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis
title_short	Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis
title_full	Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis
title_fullStr	Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis
title_full_unstemmed	Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis
title_sort	intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and zno supplementation but only subtle microbiota effects with bacillus altitudinis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9de95a60928444faae110c2bca36f15
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Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis

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