The effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes
Objective. To determine the levels of fibroblast transforming growth factor (TGF?1), basic fibroblast growth factor (?-FGF), markers of nonspecific inflammatory response (interleukin-6 (IL-6)), C-reactive protein (CRP), advanced glycation end-products (AGEs) and their receptors (RAGEs) and to study...
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Endocrinology Research Centre
2014
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oai:doaj.org-article:b9e0cb3b58644a6e8d6dd1d79c33d4632021-11-14T09:00:19ZThe effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes2072-03512072-037810.14341/DM2014247-55https://doaj.org/article/b9e0cb3b58644a6e8d6dd1d79c33d4632014-07-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6400https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Objective. To determine the levels of fibroblast transforming growth factor (TGF?1), basic fibroblast growth factor (?-FGF), markers of nonspecific inflammatory response (interleukin-6 (IL-6)), C-reactive protein (CRP), advanced glycation end-products (AGEs) and their receptors (RAGEs) and to study their effect on the intima-media complex (IMC) thickness in patients with coronary heart disease (CHD) and type 2 diabetes, depending on carbohydrate metabolism compensation. Materials and Methods. 37 patients with CHD underwent a general clinical examination, analysis of the carbohydrate and lipid metabolism parameters and the renal function, and also were evaluated with instrumental methods of analysis (echocardiography, coronary angiography and duplex scanning of the brachiocephalic arteries). To determine the level of the analyzed parameters, blood samples were taken from the aorta during coronary angiography and concomitantly from the cubital vein in all patients. Results. The presence of diabetes mellitus (DM) in patients with CHD was found to be associated with a more severe atherosclerotic disease of the coronary and brachiocephalic vessels. A direct correlation between the degree of stenosis and the level of fibroblast growth factors, inflammatory factors, and advanced glycation end-products was found. A direct correlation between AGE and TGF?1 and the lipid metabolism parameters was established. A statistically significant elevation of the studied parameters in the arterial and venous blood of patients with DM was revealed. Conclusion. These findings confirm the relationship between connective tissue disorders and lipid metabolism in the pathogenesis of atherosclerosis. A negative effect of hyperglycaemia on atherosclerotic changes of the vascular wall was demonstrated.Ekaterina Vladimirovna IvannikovaVictor Yurievich KalashnikovOlga Mikhailovna SmirnovaAlexander Borisovich KuznetsovAnatolievich TerekhinAlexander Viktorovich Il'inEndocrinology Research Centrearticlefibroblast growth factorsintima-media complexadvanced glycation end-productsdiabetesatherosclerosisNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 2, Pp 47-55 (2014) |
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EN RU |
| topic |
fibroblast growth factors intima-media complex advanced glycation end-products diabetes atherosclerosis Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
fibroblast growth factors intima-media complex advanced glycation end-products diabetes atherosclerosis Nutritional diseases. Deficiency diseases RC620-627 Ekaterina Vladimirovna Ivannikova Victor Yurievich Kalashnikov Olga Mikhailovna Smirnova Alexander Borisovich Kuznetsov Anatolievich Terekhin Alexander Viktorovich Il'in The effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes |
| description |
Objective. To determine the levels of fibroblast transforming growth factor (TGF?1), basic fibroblast growth factor (?-FGF), markers of nonspecific inflammatory response (interleukin-6 (IL-6)), C-reactive protein (CRP), advanced glycation end-products (AGEs) and their receptors (RAGEs) and to study their effect on the intima-media complex (IMC) thickness in patients with coronary heart disease (CHD) and type 2 diabetes, depending on carbohydrate metabolism compensation. Materials and Methods. 37 patients with CHD underwent a general clinical examination, analysis of the carbohydrate and lipid metabolism parameters and the renal function, and also were evaluated with instrumental methods of analysis (echocardiography, coronary angiography and duplex scanning of the brachiocephalic arteries). To determine the level of the analyzed parameters, blood samples were taken from the aorta during coronary angiography and concomitantly from the cubital vein in all patients. Results. The presence of diabetes mellitus (DM) in patients with CHD was found to be associated with a more severe atherosclerotic disease of the coronary and brachiocephalic vessels. A direct correlation between the degree of stenosis and the level of fibroblast growth factors, inflammatory factors, and advanced glycation end-products was found. A direct correlation between AGE and TGF?1 and the lipid metabolism parameters was established. A statistically significant elevation of the studied parameters in the arterial and venous blood of patients with DM was revealed. Conclusion. These findings confirm the relationship between connective tissue disorders and lipid metabolism in the pathogenesis of atherosclerosis. A negative effect of hyperglycaemia on atherosclerotic changes of the vascular wall was demonstrated. |
| format |
article |
| author |
Ekaterina Vladimirovna Ivannikova Victor Yurievich Kalashnikov Olga Mikhailovna Smirnova Alexander Borisovich Kuznetsov Anatolievich Terekhin Alexander Viktorovich Il'in |
| author_facet |
Ekaterina Vladimirovna Ivannikova Victor Yurievich Kalashnikov Olga Mikhailovna Smirnova Alexander Borisovich Kuznetsov Anatolievich Terekhin Alexander Viktorovich Il'in |
| author_sort |
Ekaterina Vladimirovna Ivannikova |
| title |
The effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes |
| title_short |
The effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes |
| title_full |
The effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes |
| title_fullStr |
The effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes |
| title_full_unstemmed |
The effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes |
| title_sort |
effect of fibroblast growth factors and advanced glycation end-products on the intima-media complex thickness in patients with coronary heart disease and type 2 diabetes |
| publisher |
Endocrinology Research Centre |
| publishDate |
2014 |
| url |
https://doaj.org/article/b9e0cb3b58644a6e8d6dd1d79c33d463 |
| work_keys_str_mv |
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| _version_ |
1718429553101111296 |