Disparity between central and peripheral refraction inheritance in twins

Disparity between central and peripheral refraction inheritance in twins

Abstract The last decades have witnessed a sudden increase in myopia incidence among youngsters that have been related to modern lifestyle along with the use of emerging technologies affecting visual exposure. Increasing exposures to known risk factors for myopia, such as time spent indoors, close-d...

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Autores principales: Dibyendu Pusti, Antonio Benito, Juan J. Madrid-Valero, Juan R. Ordoñana, Pablo Artal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b9e57336105746c7b13ccf178df36759
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spelling oai:doaj.org-article:b9e57336105746c7b13ccf178df367592021-12-02T17:52:42ZDisparity between central and peripheral refraction inheritance in twins10.1038/s41598-021-90838-82045-2322https://doaj.org/article/b9e57336105746c7b13ccf178df367592021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90838-8https://doaj.org/toc/2045-2322Abstract The last decades have witnessed a sudden increase in myopia incidence among youngsters that have been related to modern lifestyle along with the use of emerging technologies affecting visual exposure. Increasing exposures to known risk factors for myopia, such as time spent indoors, close-distance work, or low-light conditions are thought to be responsible for this public health issue. In most cases, development of myopia is secondary to a vitreous chamber enlargement, although the related mechanisms and the potential interaction between central and peripheral retinal area remain unclear. For a better understanding, we performed a classical twin study where objective refractive error along 70° of horizontal retinal arc was measured in 100 twin pairs of university students, 78% of which showed manifest myopia. We found the variance of shared environmental origin (range 0.34 to 0.67) explained most of the objective refractive error variance within central 42° of the retina (22° temporal to 19° nasal), whereas additive genetic variance (range 0.34 to 0.76) was predominant in the peripheral retinal areas measured. In this sample of millennial university students, with a large prevalence of myopia, environmental exposures were mostly responsible for inter-individual variation in the retinal horizontal area surrounding the macula, while their relative weight on phenotypic variance was gradually descending, and replaced by the variance of genetic origin, towards the retinal periphery.Dibyendu PustiAntonio BenitoJuan J. Madrid-ValeroJuan R. OrdoñanaPablo ArtalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Dibyendu Pusti
Antonio Benito
Juan J. Madrid-Valero
Juan R. Ordoñana
Pablo Artal
Disparity between central and peripheral refraction inheritance in twins
description Abstract The last decades have witnessed a sudden increase in myopia incidence among youngsters that have been related to modern lifestyle along with the use of emerging technologies affecting visual exposure. Increasing exposures to known risk factors for myopia, such as time spent indoors, close-distance work, or low-light conditions are thought to be responsible for this public health issue. In most cases, development of myopia is secondary to a vitreous chamber enlargement, although the related mechanisms and the potential interaction between central and peripheral retinal area remain unclear. For a better understanding, we performed a classical twin study where objective refractive error along 70° of horizontal retinal arc was measured in 100 twin pairs of university students, 78% of which showed manifest myopia. We found the variance of shared environmental origin (range 0.34 to 0.67) explained most of the objective refractive error variance within central 42° of the retina (22° temporal to 19° nasal), whereas additive genetic variance (range 0.34 to 0.76) was predominant in the peripheral retinal areas measured. In this sample of millennial university students, with a large prevalence of myopia, environmental exposures were mostly responsible for inter-individual variation in the retinal horizontal area surrounding the macula, while their relative weight on phenotypic variance was gradually descending, and replaced by the variance of genetic origin, towards the retinal periphery.
format article
author Dibyendu Pusti
Antonio Benito
Juan J. Madrid-Valero
Juan R. Ordoñana
Pablo Artal
author_facet Dibyendu Pusti
Antonio Benito
Juan J. Madrid-Valero
Juan R. Ordoñana
Pablo Artal
author_sort Dibyendu Pusti
title Disparity between central and peripheral refraction inheritance in twins
title_short Disparity between central and peripheral refraction inheritance in twins
title_full Disparity between central and peripheral refraction inheritance in twins
title_fullStr Disparity between central and peripheral refraction inheritance in twins
title_full_unstemmed Disparity between central and peripheral refraction inheritance in twins
title_sort disparity between central and peripheral refraction inheritance in twins
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b9e57336105746c7b13ccf178df36759
work_keys_str_mv AT dibyendupusti disparitybetweencentralandperipheralrefractioninheritanceintwins
AT antoniobenito disparitybetweencentralandperipheralrefractioninheritanceintwins
AT juanjmadridvalero disparitybetweencentralandperipheralrefractioninheritanceintwins
AT juanrordonana disparitybetweencentralandperipheralrefractioninheritanceintwins
AT pabloartal disparitybetweencentralandperipheralrefractioninheritanceintwins
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