Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature

Abstract Determining the cause of focal segmental glomerulosclerosis (FSGS) has crucial implications for evaluating the risk of posttransplant recurrence. The degree of foot process effacement (FPE) on electron micrographs (EM) of native kidney biopsies can reportedly differentiate primary FSGS from...

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Autores principales:	Kiyonobu Ishizuka, Kenichiro Miura, Taeko Hashimoto, Naoto Kaneko, Yutaka Harita, Tomoo Yabuuchi, Masataka Hisano, Shuichiro Fujinaga, Tae Omori, Yutaka Yamaguchi, Motoshi Hattori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9e7060f78464a0dba6b0f0444f37379
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spelling	oai:doaj.org-article:b9e7060f78464a0dba6b0f0444f373792021-12-02T17:48:00ZDegree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature10.1038/s41598-021-91520-92045-2322https://doaj.org/article/b9e7060f78464a0dba6b0f0444f373792021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91520-9https://doaj.org/toc/2045-2322Abstract Determining the cause of focal segmental glomerulosclerosis (FSGS) has crucial implications for evaluating the risk of posttransplant recurrence. The degree of foot process effacement (FPE) on electron micrographs (EM) of native kidney biopsies can reportedly differentiate primary FSGS from secondary FSGS. However, no systematic evaluation of FPE in genetic FSGS has been performed. In this study, percentage of FPE and foot process width (FPW) in native kidney biopsies were analyzed in eight genetic FSGS patients and nine primary FSGS patients. All genetic FSGS patients showed segmental FPE up to 38% and FPW below 2000 nm, while all primary FSGS patients showed diffuse FPE above 88% and FPW above 3000 nm. We reviewed the literature which described the degree of FPE in genetic FSGS patients and identified 38 patients with a description of the degree of FPE. The degree of FPE in patients with mutations in the genes encoding proteins associated with slit diaphragm and cytoskeletal proteins was varied, while almost all patients with mutations in other FSGS genes showed segmental FPE. In conclusion, the present study suggests that the degree of FPE in native kidney biopsies may be useful for differentiating some genetic FSGS patients from primary FSGS patients.Kiyonobu IshizukaKenichiro MiuraTaeko HashimotoNaoto KanekoYutaka HaritaTomoo YabuuchiMasataka HisanoShuichiro FujinagaTae OmoriYutaka YamaguchiMotoshi HattoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kiyonobu Ishizuka Kenichiro Miura Taeko Hashimoto Naoto Kaneko Yutaka Harita Tomoo Yabuuchi Masataka Hisano Shuichiro Fujinaga Tae Omori Yutaka Yamaguchi Motoshi Hattori Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
description	Abstract Determining the cause of focal segmental glomerulosclerosis (FSGS) has crucial implications for evaluating the risk of posttransplant recurrence. The degree of foot process effacement (FPE) on electron micrographs (EM) of native kidney biopsies can reportedly differentiate primary FSGS from secondary FSGS. However, no systematic evaluation of FPE in genetic FSGS has been performed. In this study, percentage of FPE and foot process width (FPW) in native kidney biopsies were analyzed in eight genetic FSGS patients and nine primary FSGS patients. All genetic FSGS patients showed segmental FPE up to 38% and FPW below 2000 nm, while all primary FSGS patients showed diffuse FPE above 88% and FPW above 3000 nm. We reviewed the literature which described the degree of FPE in genetic FSGS patients and identified 38 patients with a description of the degree of FPE. The degree of FPE in patients with mutations in the genes encoding proteins associated with slit diaphragm and cytoskeletal proteins was varied, while almost all patients with mutations in other FSGS genes showed segmental FPE. In conclusion, the present study suggests that the degree of FPE in native kidney biopsies may be useful for differentiating some genetic FSGS patients from primary FSGS patients.
format	article
author	Kiyonobu Ishizuka Kenichiro Miura Taeko Hashimoto Naoto Kaneko Yutaka Harita Tomoo Yabuuchi Masataka Hisano Shuichiro Fujinaga Tae Omori Yutaka Yamaguchi Motoshi Hattori
author_facet	Kiyonobu Ishizuka Kenichiro Miura Taeko Hashimoto Naoto Kaneko Yutaka Harita Tomoo Yabuuchi Masataka Hisano Shuichiro Fujinaga Tae Omori Yutaka Yamaguchi Motoshi Hattori
author_sort	Kiyonobu Ishizuka
title	Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
title_short	Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
title_full	Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
title_fullStr	Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
title_full_unstemmed	Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
title_sort	degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9e7060f78464a0dba6b0f0444f37379
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Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature

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