Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles

Abstract Nanobubbles (NBs) are of high interest for ultrasound (US) imaging as contrast agents and therapy as cavitation nuclei. Because of their instability (Laplace pressure bubble catastrophe) and low sensitivity to US, reducing the size of commonly used microbubbles to submicron-size is not triv...

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Autores principales:	Maxime Lafond, Akiko Watanabe, Shin Yoshizawa, Shin-ichiro Umemura, Katsuro Tachibana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9ee13b7049d4d33869531225311c590
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spelling	oai:doaj.org-article:b9ee13b7049d4d33869531225311c5902021-12-02T12:32:22ZCavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles10.1038/s41598-018-25913-82045-2322https://doaj.org/article/b9ee13b7049d4d33869531225311c5902018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25913-8https://doaj.org/toc/2045-2322Abstract Nanobubbles (NBs) are of high interest for ultrasound (US) imaging as contrast agents and therapy as cavitation nuclei. Because of their instability (Laplace pressure bubble catastrophe) and low sensitivity to US, reducing the size of commonly used microbubbles to submicron-size is not trivial. We introduce stabilized NBs in the 100–250-nm size range, manufactured by agitating human serum albumin and perfluoro-propane. These NBs were exposed to 3.34- and 5.39-MHz US, and their sensitivity to US was proven by detecting inertial cavitation. The cavitation-threshold information was used to run a numerical parametric study based on a modified Rayleigh-Plesset equation (with a Newtonian rheology model). The determined values of surface tension ranged from 0 N/m to 0.06 N/m. The corresponding values of dilatational viscosity ranged from 5.10−10 Ns/m to 1.10−9 Ns/m. These parameters were reported to be 0.6 N/m and 1.10−8 Ns/m for the reference microbubble contrast agent. This result suggests the possibility of using albumin as a stabilizer for the nanobubbles that could be maintained in circulation and presenting satisfying US sensitivity, even in the 3–5-MHz range.Maxime LafondAkiko WatanabeShin YoshizawaShin-ichiro UmemuraKatsuro TachibanaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maxime Lafond Akiko Watanabe Shin Yoshizawa Shin-ichiro Umemura Katsuro Tachibana Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles
description	Abstract Nanobubbles (NBs) are of high interest for ultrasound (US) imaging as contrast agents and therapy as cavitation nuclei. Because of their instability (Laplace pressure bubble catastrophe) and low sensitivity to US, reducing the size of commonly used microbubbles to submicron-size is not trivial. We introduce stabilized NBs in the 100–250-nm size range, manufactured by agitating human serum albumin and perfluoro-propane. These NBs were exposed to 3.34- and 5.39-MHz US, and their sensitivity to US was proven by detecting inertial cavitation. The cavitation-threshold information was used to run a numerical parametric study based on a modified Rayleigh-Plesset equation (with a Newtonian rheology model). The determined values of surface tension ranged from 0 N/m to 0.06 N/m. The corresponding values of dilatational viscosity ranged from 5.10−10 Ns/m to 1.10−9 Ns/m. These parameters were reported to be 0.6 N/m and 1.10−8 Ns/m for the reference microbubble contrast agent. This result suggests the possibility of using albumin as a stabilizer for the nanobubbles that could be maintained in circulation and presenting satisfying US sensitivity, even in the 3–5-MHz range.
format	article
author	Maxime Lafond Akiko Watanabe Shin Yoshizawa Shin-ichiro Umemura Katsuro Tachibana
author_facet	Maxime Lafond Akiko Watanabe Shin Yoshizawa Shin-ichiro Umemura Katsuro Tachibana
author_sort	Maxime Lafond
title	Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles
title_short	Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles
title_full	Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles
title_fullStr	Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles
title_full_unstemmed	Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles
title_sort	cavitation-threshold determination and rheological-parameters estimation of albumin-stabilized nanobubbles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b9ee13b7049d4d33869531225311c590
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Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles

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