Frailty Related to the Exposure to Particulate Matter and Ozone: The Korean Frailty and Aging Cohort Study
This study aims to identify the association between the concentration of particulate matter <2.5 μm (PM<sub>2.5</sub>), <10 μm (PM<sub>10</sub>), and ozone (O<sub>3</sub>) and frailty. The Korean Frailty Scale (KFS, 0–6 points) assessing physical, psychologi...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b9ef035743404dea86aa4df1299d6bf7 |
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| Sumario: | This study aims to identify the association between the concentration of particulate matter <2.5 μm (PM<sub>2.5</sub>), <10 μm (PM<sub>10</sub>), and ozone (O<sub>3</sub>) and frailty. The Korean Frailty Scale (KFS, 0–6 points) assessing physical, psychological, and social frailty, was applied to 2912 community-dwelling older adults between April 2016 and December 2017. Daily average concentrations of PM<sub>2.5</sub>, PM<sub>10</sub>, and O<sub>3</sub> (2015–2017) were obtained and matched with the residential areas. The frailty risk associated with exposure to PM<sub>2.5</sub>, PM<sub>10</sub>, and O<sub>3</sub> was evaluated using multiple logistic regression after adjusting for age, sex, BMI, lifestyle, socioeconomic status, and comorbidity. Participants were categorized into robust (0 points, 28.7%), pre-frail (1–2 points, 50.1%), and frail (≥3 points, 21.2%) groups. Each 1 μg/m<sup>3</sup> increase of PM<sub>2.5</sub> and PM<sub>10</sub> increased the odds ratios (ORs) and 95% confidence intervals (CIs) of the frail group compared to the robust group: 1.055 (1.002, 1.112) and 1.095 (1.060, 1.131), and the pre-frail group: 1.053 (1.017, 1.090) and 1.062 (1.037, 1.087), respectively. Each 1-ppb increase of O<sub>3</sub> increased the OR (95% CI) of the frail group: 1.041 (1.023, 1.059) and the pre-frail group: 1.005 (0.985, 1.025). PM<sub>2.5</sub>, PM<sub>10</sub>, and O<sub>3</sub> may be associated dose-dependently with the frailty. |
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