Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis

Yao-Xing Dou,1,2,* Jiang-Tao Zhou,3,4,* Tong-Tong Wang,2 Yan-Feng Huang,1 Vicky Ping Chen,5 You-Liang Xie,1 Zhi-Xiu Lin,6 Jian-Sheng Gao,7 Zi-Ren Su,1 Hui-Fang Zeng2 1Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republ...

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Autores principales: Dou Y, Zhou J, Wang T, Huang Y, Chen VP, Xie Y, Lin ZX, Gao J, Su Z, Zeng H
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Publicado: Dove Medical Press 2018
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spelling oai:doaj.org-article:b9f2cf143a374b85afcd8d4ef1381ed22021-12-02T06:13:43ZSelf-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis1178-2013https://doaj.org/article/b9f2cf143a374b85afcd8d4ef1381ed22018-09-01T00:00:00Zhttps://www.dovepress.com/self-nanoemulsfiying-drug-delivery-system-of-bruceine-d-a-new-approach-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yao-Xing Dou,1,2,* Jiang-Tao Zhou,3,4,* Tong-Tong Wang,2 Yan-Feng Huang,1 Vicky Ping Chen,5 You-Liang Xie,1 Zhi-Xiu Lin,6 Jian-Sheng Gao,7 Zi-Ren Su,1 Hui-Fang Zeng2 1Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 3School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 4Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, People’s Republic of China; 5Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA; 6School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 7Guangzhou Baiyunshan Mingxing Pharmaceutical Co. Ltd., Guangzhou, People’s Republic of China *These authors contributed equally to this work Background: Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]). Methods: To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model. Results: The prepared nanoemulsion has multiple beneficial aspects including small mean droplet size, low polydispersity index (PDI), high zeta potential (ZP) and excellent stability. Transmission electron microscopy showed that nanoemulsion droplets contained uniform shape and size of globules. Pharmacokinetic studies demonstrated that BD-SNEDDS exhibited enhanced pharmacokinetic parameters as compared with BD-suspension. Moreover, BD-SNEDDS significantly restored the colon length and body weight, reduced disease activity index (DAI) and colon pathology, decreased histological scores, diminished oxidative stress, and suppressed TLR4, MyD88, TRAF6, NF-κB p65 protein expressions in TNBS-induced UC rat model. Conclusion: These results demonstrated that BD-SNEDDS exhibited highly improved oral bioavailability and advanced anti-UC efficacy. In conclusion, our current results provided a foundation for further research of BD-SNEDDS as a potential complementary therapeutic agent for UC treatment. Keywords: bruceine D, self-nanoemulsifying drug delivery system, physicochemical properties, pharmacokinetics, anti-inflammation, anti-colitis activityDou YZhou JWang THuang YChen VPXie YLin ZXGao JSu ZZeng HDove Medical PressarticleBruceine Dself-nanoemulsifying drug delivery systempharmacokineticsanti-inflammationanti-colitis activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5887-5907 (2018)
institution DOAJ
collection DOAJ
language EN
topic Bruceine D
self-nanoemulsifying drug delivery system
pharmacokinetics
anti-inflammation
anti-colitis activity
Medicine (General)
R5-920
spellingShingle Bruceine D
self-nanoemulsifying drug delivery system
pharmacokinetics
anti-inflammation
anti-colitis activity
Medicine (General)
R5-920
Dou Y
Zhou J
Wang T
Huang Y
Chen VP
Xie Y
Lin ZX
Gao J
Su Z
Zeng H
Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
description Yao-Xing Dou,1,2,* Jiang-Tao Zhou,3,4,* Tong-Tong Wang,2 Yan-Feng Huang,1 Vicky Ping Chen,5 You-Liang Xie,1 Zhi-Xiu Lin,6 Jian-Sheng Gao,7 Zi-Ren Su,1 Hui-Fang Zeng2 1Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 3School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 4Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, People’s Republic of China; 5Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA; 6School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 7Guangzhou Baiyunshan Mingxing Pharmaceutical Co. Ltd., Guangzhou, People’s Republic of China *These authors contributed equally to this work Background: Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]). Methods: To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model. Results: The prepared nanoemulsion has multiple beneficial aspects including small mean droplet size, low polydispersity index (PDI), high zeta potential (ZP) and excellent stability. Transmission electron microscopy showed that nanoemulsion droplets contained uniform shape and size of globules. Pharmacokinetic studies demonstrated that BD-SNEDDS exhibited enhanced pharmacokinetic parameters as compared with BD-suspension. Moreover, BD-SNEDDS significantly restored the colon length and body weight, reduced disease activity index (DAI) and colon pathology, decreased histological scores, diminished oxidative stress, and suppressed TLR4, MyD88, TRAF6, NF-κB p65 protein expressions in TNBS-induced UC rat model. Conclusion: These results demonstrated that BD-SNEDDS exhibited highly improved oral bioavailability and advanced anti-UC efficacy. In conclusion, our current results provided a foundation for further research of BD-SNEDDS as a potential complementary therapeutic agent for UC treatment. Keywords: bruceine D, self-nanoemulsifying drug delivery system, physicochemical properties, pharmacokinetics, anti-inflammation, anti-colitis activity
format article
author Dou Y
Zhou J
Wang T
Huang Y
Chen VP
Xie Y
Lin ZX
Gao J
Su Z
Zeng H
author_facet Dou Y
Zhou J
Wang T
Huang Y
Chen VP
Xie Y
Lin ZX
Gao J
Su Z
Zeng H
author_sort Dou Y
title Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_short Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_full Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_fullStr Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_full_unstemmed Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_sort self-nanoemulsfiying drug delivery system of bruceine d: a new approach for anti-ulcerative colitis
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/b9f2cf143a374b85afcd8d4ef1381ed2
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