Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis

Yao-Xing Dou,1,2,* Jiang-Tao Zhou,3,4,* Tong-Tong Wang,2 Yan-Feng Huang,1 Vicky Ping Chen,5 You-Liang Xie,1 Zhi-Xiu Lin,6 Jian-Sheng Gao,7 Zi-Ren Su,1 Hui-Fang Zeng2 1Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republ...

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Autores principales:	Dou Y, Zhou J, Wang T, Huang Y, Chen VP, Xie Y, Lin ZX, Gao J, Su Z, Zeng H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Bruceine D self-nanoemulsifying drug delivery system pharmacokinetics anti-inflammation anti-colitis activity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b9f2cf143a374b85afcd8d4ef1381ed2
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spelling	oai:doaj.org-article:b9f2cf143a374b85afcd8d4ef1381ed22021-12-02T06:13:43ZSelf-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis1178-2013https://doaj.org/article/b9f2cf143a374b85afcd8d4ef1381ed22018-09-01T00:00:00Zhttps://www.dovepress.com/self-nanoemulsfiying-drug-delivery-system-of-bruceine-d-a-new-approach-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yao-Xing Dou,1,2,* Jiang-Tao Zhou,3,4,* Tong-Tong Wang,2 Yan-Feng Huang,1 Vicky Ping Chen,5 You-Liang Xie,1 Zhi-Xiu Lin,6 Jian-Sheng Gao,7 Zi-Ren Su,1 Hui-Fang Zeng2 1Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 3School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 4Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, People’s Republic of China; 5Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA; 6School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 7Guangzhou Baiyunshan Mingxing Pharmaceutical Co. Ltd., Guangzhou, People’s Republic of China *These authors contributed equally to this work Background: Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]). Methods: To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model. Results: The prepared nanoemulsion has multiple beneficial aspects including small mean droplet size, low polydispersity index (PDI), high zeta potential (ZP) and excellent stability. Transmission electron microscopy showed that nanoemulsion droplets contained uniform shape and size of globules. Pharmacokinetic studies demonstrated that BD-SNEDDS exhibited enhanced pharmacokinetic parameters as compared with BD-suspension. Moreover, BD-SNEDDS significantly restored the colon length and body weight, reduced disease activity index (DAI) and colon pathology, decreased histological scores, diminished oxidative stress, and suppressed TLR4, MyD88, TRAF6, NF-κB p65 protein expressions in TNBS-induced UC rat model. Conclusion: These results demonstrated that BD-SNEDDS exhibited highly improved oral bioavailability and advanced anti-UC efficacy. In conclusion, our current results provided a foundation for further research of BD-SNEDDS as a potential complementary therapeutic agent for UC treatment. Keywords: bruceine D, self-nanoemulsifying drug delivery system, physicochemical properties, pharmacokinetics, anti-inflammation, anti-colitis activityDou YZhou JWang THuang YChen VPXie YLin ZXGao JSu ZZeng HDove Medical PressarticleBruceine Dself-nanoemulsifying drug delivery systempharmacokineticsanti-inflammationanti-colitis activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5887-5907 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bruceine D self-nanoemulsifying drug delivery system pharmacokinetics anti-inflammation anti-colitis activity Medicine (General) R5-920
spellingShingle	Bruceine D self-nanoemulsifying drug delivery system pharmacokinetics anti-inflammation anti-colitis activity Medicine (General) R5-920 Dou Y Zhou J Wang T Huang Y Chen VP Xie Y Lin ZX Gao J Su Z Zeng H Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
description	Yao-Xing Dou,1,2,* Jiang-Tao Zhou,3,4,* Tong-Tong Wang,2 Yan-Feng Huang,1 Vicky Ping Chen,5 You-Liang Xie,1 Zhi-Xiu Lin,6 Jian-Sheng Gao,7 Zi-Ren Su,1 Hui-Fang Zeng2 1Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 3School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 4Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, People’s Republic of China; 5Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA; 6School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 7Guangzhou Baiyunshan Mingxing Pharmaceutical Co. Ltd., Guangzhou, People’s Republic of China *These authors contributed equally to this work Background: Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]). Methods: To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model. Results: The prepared nanoemulsion has multiple beneficial aspects including small mean droplet size, low polydispersity index (PDI), high zeta potential (ZP) and excellent stability. Transmission electron microscopy showed that nanoemulsion droplets contained uniform shape and size of globules. Pharmacokinetic studies demonstrated that BD-SNEDDS exhibited enhanced pharmacokinetic parameters as compared with BD-suspension. Moreover, BD-SNEDDS significantly restored the colon length and body weight, reduced disease activity index (DAI) and colon pathology, decreased histological scores, diminished oxidative stress, and suppressed TLR4, MyD88, TRAF6, NF-κB p65 protein expressions in TNBS-induced UC rat model. Conclusion: These results demonstrated that BD-SNEDDS exhibited highly improved oral bioavailability and advanced anti-UC efficacy. In conclusion, our current results provided a foundation for further research of BD-SNEDDS as a potential complementary therapeutic agent for UC treatment. Keywords: bruceine D, self-nanoemulsifying drug delivery system, physicochemical properties, pharmacokinetics, anti-inflammation, anti-colitis activity
format	article
author	Dou Y Zhou J Wang T Huang Y Chen VP Xie Y Lin ZX Gao J Su Z Zeng H
author_facet	Dou Y Zhou J Wang T Huang Y Chen VP Xie Y Lin ZX Gao J Su Z Zeng H
author_sort	Dou Y
title	Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_short	Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_full	Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_fullStr	Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_full_unstemmed	Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis
title_sort	self-nanoemulsfiying drug delivery system of bruceine d: a new approach for anti-ulcerative colitis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/b9f2cf143a374b85afcd8d4ef1381ed2
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Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis

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