Immunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking

Abstract Panax ginseng is one of the oldest and most generally prescribed herbs in Eastern traditional medicine to treat diseases. Several studies had documented that ginseng leaves have anti-oxidative, anti-inflammatory, and anticancer properties similar to those of ginseng root. The aim of this re...

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Autores principales:	Zao-Hui Li, Dan Yu, Nan-Nan Huang, Jun-Kai Wu, Xiao-Wei Du, Xi-Jun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9f2d8584a9d4f9d9765582254efdde7
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spelling	oai:doaj.org-article:b9f2d8584a9d4f9d9765582254efdde72021-12-02T15:16:05ZImmunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking10.1038/s41598-021-97115-82045-2322https://doaj.org/article/b9f2d8584a9d4f9d9765582254efdde72021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97115-8https://doaj.org/toc/2045-2322Abstract Panax ginseng is one of the oldest and most generally prescribed herbs in Eastern traditional medicine to treat diseases. Several studies had documented that ginseng leaves have anti-oxidative, anti-inflammatory, and anticancer properties similar to those of ginseng root. The aim of this research was to forecast of the molecular mechanism of ginseng leaves on lung cancer by molecular docking and network pharmacology so as to decipher ginseng leaves' entire mechanism. The compounds associated with ginseng leaves were searched by TCMSP. TCMSP and Swiss Target Prediction databases were used to sort out the potential targets of the main chemical components. Targets were collected from OMIM, PharmGKB, TTD, DrugBank and GeneCards which related to immunity and lung cancer. Ginseng leaves exert its lung cancer suppressive function by regulating the several signaling proteins, such as JUN, STAT3, AKT1, TNF, MAPK1, TP53. GO and KEGG analyses indicated that the immunoreaction against lung cancer by ginseng leaves might be related to response to lipopolysaccharide, response to oxidative stress, PI3K-Akt, MAPK and TNF pathway. Molecular docking analysis demonstrated that hydrogen bonding was interaction's core forms. The results of CCK8 test and qRT-PCR showed that ginseng leaves inhibit cell proliferation and regulates AKT1 and P53 expression in A549. The present study clarifies the mechanism of Ginseng leaves against lung cancer and provides evidence to support its clinical use.Zao-Hui LiDan YuNan-Nan HuangJun-Kai WuXiao-Wei DuXi-Jun WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zao-Hui Li Dan Yu Nan-Nan Huang Jun-Kai Wu Xiao-Wei Du Xi-Jun Wang Immunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking
description	Abstract Panax ginseng is one of the oldest and most generally prescribed herbs in Eastern traditional medicine to treat diseases. Several studies had documented that ginseng leaves have anti-oxidative, anti-inflammatory, and anticancer properties similar to those of ginseng root. The aim of this research was to forecast of the molecular mechanism of ginseng leaves on lung cancer by molecular docking and network pharmacology so as to decipher ginseng leaves' entire mechanism. The compounds associated with ginseng leaves were searched by TCMSP. TCMSP and Swiss Target Prediction databases were used to sort out the potential targets of the main chemical components. Targets were collected from OMIM, PharmGKB, TTD, DrugBank and GeneCards which related to immunity and lung cancer. Ginseng leaves exert its lung cancer suppressive function by regulating the several signaling proteins, such as JUN, STAT3, AKT1, TNF, MAPK1, TP53. GO and KEGG analyses indicated that the immunoreaction against lung cancer by ginseng leaves might be related to response to lipopolysaccharide, response to oxidative stress, PI3K-Akt, MAPK and TNF pathway. Molecular docking analysis demonstrated that hydrogen bonding was interaction's core forms. The results of CCK8 test and qRT-PCR showed that ginseng leaves inhibit cell proliferation and regulates AKT1 and P53 expression in A549. The present study clarifies the mechanism of Ginseng leaves against lung cancer and provides evidence to support its clinical use.
format	article
author	Zao-Hui Li Dan Yu Nan-Nan Huang Jun-Kai Wu Xiao-Wei Du Xi-Jun Wang
author_facet	Zao-Hui Li Dan Yu Nan-Nan Huang Jun-Kai Wu Xiao-Wei Du Xi-Jun Wang
author_sort	Zao-Hui Li
title	Immunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking
title_short	Immunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking
title_full	Immunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking
title_fullStr	Immunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking
title_full_unstemmed	Immunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking
title_sort	immunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9f2d8584a9d4f9d9765582254efdde7
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Immunoregulatory mechanism studies of ginseng leaves on lung cancer based on network pharmacology and molecular docking

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