High uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review

High uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review

Background: Recent observational studies have suggested that the patients with hyperuricemia have a higher risk of having left atrial thrombus (LATH) or left atrial spontaneous echo contrast (LASEC) by transesophageal echocardiography (TEE), while the ultimate predictive value of a high uric acid (U...

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Autores principales: En-Yuan Zhang, Lu Kou, Min Li, Chee Yuan Ng, Jian-Ping Zhao, Guang-Ping Li, Tong Liu
Formato: article
Lenguaje:EN
Publicado: KeAi Communications Co., Ltd. 2016
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/b9f414373ccb41748a5ce76af04fd2b2
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spelling oai:doaj.org-article:b9f414373ccb41748a5ce76af04fd2b22021-12-02T10:50:33ZHigh uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review2095-882X10.1016/j.cdtm.2016.02.002https://doaj.org/article/b9f414373ccb41748a5ce76af04fd2b22016-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16000050https://doaj.org/toc/2095-882XBackground: Recent observational studies have suggested that the patients with hyperuricemia have a higher risk of having left atrial thrombus (LATH) or left atrial spontaneous echo contrast (LASEC) by transesophageal echocardiography (TEE), while the ultimate predictive value of a high uric acid (UA) level on LATH/LASEC remained obscure. Methods: We searched the PubMed and Cochrane clinical trials databases up to July 2015. Following screening the 369 initially identified studies, we analyzed six observational studies with 2381 patients. Results: The meta-analysis of these studies showed that an elevated serum UA level was associated with a higher likelihood of LATH/LASEC (OR = 1.59, 95%CI 1.13â2.23, P = 0.008), while significant differences exist among individual trials (P < 0.00001 and I2 = 85%). Sensitivity analysis failed to find any heterogeneity. Conclusion: An elevated UA level was associated with a higher risk of detecting a left atrial abnormality represented by LATH/LASEC. Keywords: Uric acid, Left atrium, Thrombus, Transesophageal echocardiography, Atrial fibrillationEn-Yuan ZhangLu KouMin LiChee Yuan NgJian-Ping ZhaoGuang-Ping LiTong LiuKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 2, Iss 1, Pp 27-33 (2016)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
En-Yuan Zhang
Lu Kou
Min Li
Chee Yuan Ng
Jian-Ping Zhao
Guang-Ping Li
Tong Liu
High uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review
description Background: Recent observational studies have suggested that the patients with hyperuricemia have a higher risk of having left atrial thrombus (LATH) or left atrial spontaneous echo contrast (LASEC) by transesophageal echocardiography (TEE), while the ultimate predictive value of a high uric acid (UA) level on LATH/LASEC remained obscure. Methods: We searched the PubMed and Cochrane clinical trials databases up to July 2015. Following screening the 369 initially identified studies, we analyzed six observational studies with 2381 patients. Results: The meta-analysis of these studies showed that an elevated serum UA level was associated with a higher likelihood of LATH/LASEC (OR = 1.59, 95%CI 1.13â2.23, P = 0.008), while significant differences exist among individual trials (P < 0.00001 and I2 = 85%). Sensitivity analysis failed to find any heterogeneity. Conclusion: An elevated UA level was associated with a higher risk of detecting a left atrial abnormality represented by LATH/LASEC. Keywords: Uric acid, Left atrium, Thrombus, Transesophageal echocardiography, Atrial fibrillation
format article
author En-Yuan Zhang
Lu Kou
Min Li
Chee Yuan Ng
Jian-Ping Zhao
Guang-Ping Li
Tong Liu
author_facet En-Yuan Zhang
Lu Kou
Min Li
Chee Yuan Ng
Jian-Ping Zhao
Guang-Ping Li
Tong Liu
author_sort En-Yuan Zhang
title High uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review
title_short High uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review
title_full High uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review
title_fullStr High uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review
title_full_unstemmed High uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: Meta-analysis and systematic review
title_sort high uric acid level predicts left atrial thrombus or spontaneous echo contrast detected by transesophageal echocardiography: meta-analysis and systematic review
publisher KeAi Communications Co., Ltd.
publishDate 2016
url https://doaj.org/article/b9f414373ccb41748a5ce76af04fd2b2
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