PLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS

Аbstract. Patients with end-stage renal disease need their kidney functions to be replaced. Chronic haemodialysis represents a most common method of such substitution treatment. This procedure results in successful survival of such patients for years. Chronic haemodialysis is accompanie...

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Autores principales:	D. S. Polyakov, O. M. Domashenko, P. V. Beloborodov, K. A. Syssoev, M. M. Shavlovsky, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines haemodialysis inflammation β2-microglobulin amyloidosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b9f4b999df6742ceae3f4b1e2761a647
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spelling	oai:doaj.org-article:b9f4b999df6742ceae3f4b1e2761a6472021-11-18T08:03:42ZPLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS1563-06252313-741X10.15789/1563-0625-2011-2-3-211-218https://doaj.org/article/b9f4b999df6742ceae3f4b1e2761a6472014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/513https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XАbstract. Patients with end-stage renal disease need their kidney functions to be replaced. Chronic haemodialysis represents a most common method of such substitution treatment. This procedure results in successful survival of such patients for years. Chronic haemodialysis is accompanied by a complication which is known as β2-microglobulin amyloidosis. In this case, amyloid substance consisting of β2-microglobulin (β2-MG) accumulates in bones, ligaments and joints. Biological causes of β2-MG amyloidosis are still not established. To elucidate the role of inflammation in the pathogenesis of β2-MG amyloidosis, the levels of IL-2, IL-4, IL-6, IL-8, IL-10, GM-CSF, IFNγ, TNFα were quantified in plasma of patients undergoing long-term haemodialysis. Mean amounts of all the mentioned cytokines in haemodialysis patients proved to be significantly higher than in control group consisting of healthy subjects. When comparing a group receiving standard dialysis procedure versus a subgroup receiving haemodiafiltration, a single reliable difference was revealed for GM-CSF levels (p < 0.04), without any differences shown for other cytokines. With increasing terms of chronic haemodialysis, the levels of IL-2, IL-4, IL-6, IL-8, GM-CSF, IFNγ, TNFα were increased, or, at least, they did not decrease. After three years of dialysis, IL-10 concentrations were statistically indistinguishable from normal levels. In patients undergoing haemodiafiltration, plasma levels of IL-2, IL-4, IL-8, GM-CSF, IFNγ, TNFα did not drop with increasing terms of dialysis. The levels of IL-6 and IL-10 decreased after three years of dialysis, to near-normal levels.In general, these results suggest that IL-10 and IL-6 may be regarded as candidates for further studies as potential markers of β2-microglobulin amyloidosis. (Med. Immunol., 2011, vol. 13, N 2-3, pp 211-218)D. S. PolyakovO. M. DomashenkoP. V. BeloborodovK. A. SyssoevM. M. ShavlovskyAreg A. TotolianSPb RAACIarticlecytokineshaemodialysisinflammationβ2-microglobulinamyloidosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 211-218 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines haemodialysis inflammation β2-microglobulin amyloidosis Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines haemodialysis inflammation β2-microglobulin amyloidosis Immunologic diseases. Allergy RC581-607 D. S. Polyakov O. M. Domashenko P. V. Beloborodov K. A. Syssoev M. M. Shavlovsky Areg A. Totolian PLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS
description	Аbstract. Patients with end-stage renal disease need their kidney functions to be replaced. Chronic haemodialysis represents a most common method of such substitution treatment. This procedure results in successful survival of such patients for years. Chronic haemodialysis is accompanied by a complication which is known as β2-microglobulin amyloidosis. In this case, amyloid substance consisting of β2-microglobulin (β2-MG) accumulates in bones, ligaments and joints. Biological causes of β2-MG amyloidosis are still not established. To elucidate the role of inflammation in the pathogenesis of β2-MG amyloidosis, the levels of IL-2, IL-4, IL-6, IL-8, IL-10, GM-CSF, IFNγ, TNFα were quantified in plasma of patients undergoing long-term haemodialysis. Mean amounts of all the mentioned cytokines in haemodialysis patients proved to be significantly higher than in control group consisting of healthy subjects. When comparing a group receiving standard dialysis procedure versus a subgroup receiving haemodiafiltration, a single reliable difference was revealed for GM-CSF levels (p < 0.04), without any differences shown for other cytokines. With increasing terms of chronic haemodialysis, the levels of IL-2, IL-4, IL-6, IL-8, GM-CSF, IFNγ, TNFα were increased, or, at least, they did not decrease. After three years of dialysis, IL-10 concentrations were statistically indistinguishable from normal levels. In patients undergoing haemodiafiltration, plasma levels of IL-2, IL-4, IL-8, GM-CSF, IFNγ, TNFα did not drop with increasing terms of dialysis. The levels of IL-6 and IL-10 decreased after three years of dialysis, to near-normal levels.In general, these results suggest that IL-10 and IL-6 may be regarded as candidates for further studies as potential markers of β2-microglobulin amyloidosis. (Med. Immunol., 2011, vol. 13, N 2-3, pp 211-218)
format	article
author	D. S. Polyakov O. M. Domashenko P. V. Beloborodov K. A. Syssoev M. M. Shavlovsky Areg A. Totolian
author_facet	D. S. Polyakov O. M. Domashenko P. V. Beloborodov K. A. Syssoev M. M. Shavlovsky Areg A. Totolian
author_sort	D. S. Polyakov
title	PLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS
title_short	PLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS
title_full	PLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS
title_fullStr	PLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS
title_full_unstemmed	PLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS
title_sort	plasma cytokines levels in patients undergoing long-term haemodialysis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b9f4b999df6742ceae3f4b1e2761a647
work_keys_str_mv	AT dspolyakov plasmacytokineslevelsinpatientsundergoinglongtermhaemodialysis AT omdomashenko plasmacytokineslevelsinpatientsundergoinglongtermhaemodialysis AT pvbeloborodov plasmacytokineslevelsinpatientsundergoinglongtermhaemodialysis AT kasyssoev plasmacytokineslevelsinpatientsundergoinglongtermhaemodialysis AT mmshavlovsky plasmacytokineslevelsinpatientsundergoinglongtermhaemodialysis AT aregatotolian plasmacytokineslevelsinpatientsundergoinglongtermhaemodialysis
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PLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS

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