Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation
Heteroplasmic mtDNA mutations cause disease in humans. Here, Chung et al find the PI3K-Akt-mTORC1 pathway constitutively activated in cells with the heteroplasmic m.3243 A > G mutation, and inhibition of the pathway cell autonomously reduces mutant mtDNA load and rescues mitochondrial bioenergeti...
Guardado en:
Autores principales: | Chih-Yao Chung, Kritarth Singh, Vassilios N. Kotiadis, Gabriel E. Valdebenito, Jee Hwan Ahn, Emilie Topley, Joycelyn Tan, William D. Andrews, Benoit Bilanges, Robert D. S. Pitceathly, Gyorgy Szabadkai, Mariia Yuneva, Michael R. Duchen |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/b9f6630675044451be3ddb118624adeb |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Xiaolei Ding, et al.
Publicado: (2016) -
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
por: Morris E Feldman, et al.
Publicado: (2009) -
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
por: Fangjie Wang, et al.
Publicado: (2018) -
Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
por: Huishan Tao, et al.
Publicado: (2021) -
Regulation of colonic epithelial cell homeostasis by mTORC1
por: Takenori Kotani, et al.
Publicado: (2020)