Potential New Treatments for Knee OA: A Prospective Review of Registered Trials
We aimed to evaluate potential new treatments for knee osteoarthritis (OA). The National Institute of Health ClinicalTrials.gov database was searched for “Osteoarthritis, Knee”. We found 565 ongoing interventional studies with a total planned enrollment of 111,276 subjects. Ongoing studies for knee...
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MDPI AG
2021
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oai:doaj.org-article:b9f95c1d46e54ff499026c97f60df4ac2021-11-25T16:43:17ZPotential New Treatments for Knee OA: A Prospective Review of Registered Trials10.3390/app1122110492076-3417https://doaj.org/article/b9f95c1d46e54ff499026c97f60df4ac2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/11049https://doaj.org/toc/2076-3417We aimed to evaluate potential new treatments for knee osteoarthritis (OA). The National Institute of Health ClinicalTrials.gov database was searched for “Osteoarthritis, Knee”. We found 565 ongoing interventional studies with a total planned enrollment of 111,276 subjects. Ongoing studies for knee OA represent a very small fraction of the registered clinical trials, but they are over a quarter of all knee trials and over two thirds of all OA studies. The most researched topic was arthroplasty, with aspects such as implant design changes, cementless fixation, robotic guidance, pain management, and fast track recovery. Intraarticular injections focused on cell therapies with mesenchymal stem cells sourced from adipose tissue, bone marrow, or umbilical cord. We could see the introduction of the first disease modifying drugs with an impact on knee OA, as well as new procedures such as geniculate artery embolization and geniculate nerve ablation.Marius IoniţescuDinu VermeşanBogdan AndorCristian DumitrascuMusab Al-QatawnehVlad BloancaAndrei DumitrascuRadu PrejbeanuMDPI AGarticleosteoarthritiskneearthroplastyintraarticular injectionsmesenchymal stem cellsplatelet rich plasmaTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 11049, p 11049 (2021) |
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DOAJ |
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osteoarthritis knee arthroplasty intraarticular injections mesenchymal stem cells platelet rich plasma Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 |
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osteoarthritis knee arthroplasty intraarticular injections mesenchymal stem cells platelet rich plasma Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Marius Ioniţescu Dinu Vermeşan Bogdan Andor Cristian Dumitrascu Musab Al-Qatawneh Vlad Bloanca Andrei Dumitrascu Radu Prejbeanu Potential New Treatments for Knee OA: A Prospective Review of Registered Trials |
| description |
We aimed to evaluate potential new treatments for knee osteoarthritis (OA). The National Institute of Health ClinicalTrials.gov database was searched for “Osteoarthritis, Knee”. We found 565 ongoing interventional studies with a total planned enrollment of 111,276 subjects. Ongoing studies for knee OA represent a very small fraction of the registered clinical trials, but they are over a quarter of all knee trials and over two thirds of all OA studies. The most researched topic was arthroplasty, with aspects such as implant design changes, cementless fixation, robotic guidance, pain management, and fast track recovery. Intraarticular injections focused on cell therapies with mesenchymal stem cells sourced from adipose tissue, bone marrow, or umbilical cord. We could see the introduction of the first disease modifying drugs with an impact on knee OA, as well as new procedures such as geniculate artery embolization and geniculate nerve ablation. |
| format |
article |
| author |
Marius Ioniţescu Dinu Vermeşan Bogdan Andor Cristian Dumitrascu Musab Al-Qatawneh Vlad Bloanca Andrei Dumitrascu Radu Prejbeanu |
| author_facet |
Marius Ioniţescu Dinu Vermeşan Bogdan Andor Cristian Dumitrascu Musab Al-Qatawneh Vlad Bloanca Andrei Dumitrascu Radu Prejbeanu |
| author_sort |
Marius Ioniţescu |
| title |
Potential New Treatments for Knee OA: A Prospective Review of Registered Trials |
| title_short |
Potential New Treatments for Knee OA: A Prospective Review of Registered Trials |
| title_full |
Potential New Treatments for Knee OA: A Prospective Review of Registered Trials |
| title_fullStr |
Potential New Treatments for Knee OA: A Prospective Review of Registered Trials |
| title_full_unstemmed |
Potential New Treatments for Knee OA: A Prospective Review of Registered Trials |
| title_sort |
potential new treatments for knee oa: a prospective review of registered trials |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/b9f95c1d46e54ff499026c97f60df4ac |
| work_keys_str_mv |
AT mariusionitescu potentialnewtreatmentsforkneeoaaprospectivereviewofregisteredtrials AT dinuvermesan potentialnewtreatmentsforkneeoaaprospectivereviewofregisteredtrials AT bogdanandor potentialnewtreatmentsforkneeoaaprospectivereviewofregisteredtrials AT cristiandumitrascu potentialnewtreatmentsforkneeoaaprospectivereviewofregisteredtrials AT musabalqatawneh potentialnewtreatmentsforkneeoaaprospectivereviewofregisteredtrials AT vladbloanca potentialnewtreatmentsforkneeoaaprospectivereviewofregisteredtrials AT andreidumitrascu potentialnewtreatmentsforkneeoaaprospectivereviewofregisteredtrials AT raduprejbeanu potentialnewtreatmentsforkneeoaaprospectivereviewofregisteredtrials |
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