Irritable bowel syndrome and Parkinson’s disease risk: register-based studies

Abstract To examine whether irritable bowel syndrome (IBS) was related to the future risk of Parkinson’s disease (PD), we conducted a nested case-control study in the Swedish total population including 56,564 PD cases identified from the Swedish Patient Register and 30 controls per case individually...

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Autores principales:	Bojing Liu, Arvid Sjölander, Nancy L. Pedersen, Jonas F. Ludvigsson, Honglei Chen, Fang Fang, Karin Wirdefeldt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b9ff0e50ca7b44a9a2b5e9129a5d770d
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spelling	oai:doaj.org-article:b9ff0e50ca7b44a9a2b5e9129a5d770d2021-12-02T11:56:29ZIrritable bowel syndrome and Parkinson’s disease risk: register-based studies10.1038/s41531-020-00145-82373-8057https://doaj.org/article/b9ff0e50ca7b44a9a2b5e9129a5d770d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41531-020-00145-8https://doaj.org/toc/2373-8057Abstract To examine whether irritable bowel syndrome (IBS) was related to the future risk of Parkinson’s disease (PD), we conducted a nested case-control study in the Swedish total population including 56,564 PD cases identified from the Swedish Patient Register and 30 controls per case individually matched by sex and year of birth. Odds ratios (ORs) with 95% confidence intervals (CIs) for having a prior diagnosis of IBS were estimated using conditional logistic regression. We furthermore conducted a cohort study using the Swedish Twin Registry following 3046 IBS patients identified by self-reported abdominal symptoms and 41,179 non-IBS individuals. Through Cox proportional hazard models, we estimated hazard ratios (HRs) and 95% CIs for PD risk. In the nested case-control study, 253 (0.4%) PD cases and 5204 (0.3%) controls had a previous IBS diagnosis. IBS diagnosis was associated with a 44% higher risk of PD (OR = 1.44, 95% CI 1.27–1.63). Temporal relationship analyses showed 53% and 38% increased risk of PD more than 5 and 10 years after IBS diagnosis, respectively. In the cohort analysis based on the Swedish Twin Registry, there was no statistically significantly increased risk of PD related to IBS (HR = 1.25, 95% CI = 0.87–1.81). Our results suggest a higher risk of PD diagnosis after IBS. These results provide additional evidence supporting the importance of the gut–brain axis in PD.Bojing LiuArvid SjölanderNancy L. PedersenJonas F. LudvigssonHonglei ChenFang FangKarin WirdefeldtNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Bojing Liu Arvid Sjölander Nancy L. Pedersen Jonas F. Ludvigsson Honglei Chen Fang Fang Karin Wirdefeldt Irritable bowel syndrome and Parkinson’s disease risk: register-based studies
description	Abstract To examine whether irritable bowel syndrome (IBS) was related to the future risk of Parkinson’s disease (PD), we conducted a nested case-control study in the Swedish total population including 56,564 PD cases identified from the Swedish Patient Register and 30 controls per case individually matched by sex and year of birth. Odds ratios (ORs) with 95% confidence intervals (CIs) for having a prior diagnosis of IBS were estimated using conditional logistic regression. We furthermore conducted a cohort study using the Swedish Twin Registry following 3046 IBS patients identified by self-reported abdominal symptoms and 41,179 non-IBS individuals. Through Cox proportional hazard models, we estimated hazard ratios (HRs) and 95% CIs for PD risk. In the nested case-control study, 253 (0.4%) PD cases and 5204 (0.3%) controls had a previous IBS diagnosis. IBS diagnosis was associated with a 44% higher risk of PD (OR = 1.44, 95% CI 1.27–1.63). Temporal relationship analyses showed 53% and 38% increased risk of PD more than 5 and 10 years after IBS diagnosis, respectively. In the cohort analysis based on the Swedish Twin Registry, there was no statistically significantly increased risk of PD related to IBS (HR = 1.25, 95% CI = 0.87–1.81). Our results suggest a higher risk of PD diagnosis after IBS. These results provide additional evidence supporting the importance of the gut–brain axis in PD.
format	article
author	Bojing Liu Arvid Sjölander Nancy L. Pedersen Jonas F. Ludvigsson Honglei Chen Fang Fang Karin Wirdefeldt
author_facet	Bojing Liu Arvid Sjölander Nancy L. Pedersen Jonas F. Ludvigsson Honglei Chen Fang Fang Karin Wirdefeldt
author_sort	Bojing Liu
title	Irritable bowel syndrome and Parkinson’s disease risk: register-based studies
title_short	Irritable bowel syndrome and Parkinson’s disease risk: register-based studies
title_full	Irritable bowel syndrome and Parkinson’s disease risk: register-based studies
title_fullStr	Irritable bowel syndrome and Parkinson’s disease risk: register-based studies
title_full_unstemmed	Irritable bowel syndrome and Parkinson’s disease risk: register-based studies
title_sort	irritable bowel syndrome and parkinson’s disease risk: register-based studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9ff0e50ca7b44a9a2b5e9129a5d770d
work_keys_str_mv	AT bojingliu irritablebowelsyndromeandparkinsonsdiseaseriskregisterbasedstudies AT arvidsjolander irritablebowelsyndromeandparkinsonsdiseaseriskregisterbasedstudies AT nancylpedersen irritablebowelsyndromeandparkinsonsdiseaseriskregisterbasedstudies AT jonasfludvigsson irritablebowelsyndromeandparkinsonsdiseaseriskregisterbasedstudies AT hongleichen irritablebowelsyndromeandparkinsonsdiseaseriskregisterbasedstudies AT fangfang irritablebowelsyndromeandparkinsonsdiseaseriskregisterbasedstudies AT karinwirdefeldt irritablebowelsyndromeandparkinsonsdiseaseriskregisterbasedstudies
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Irritable bowel syndrome and Parkinson’s disease risk: register-based studies

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