Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application

Carmen L Insausti,1 Miguel Blanquer,1 Ana M García-Hernández,1 Gregorio Castellanos,2 José M Moraleda11Unidad de Trasplante Hematopoyético y Terapia Celular, 2Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca,...

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Autores principales:	Insausti CL, Blanquer M, García-Hernández AM, Castellanos G, Moraleda JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/ba0607bcfaa544598f1b093399a123db
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spelling	oai:doaj.org-article:ba0607bcfaa544598f1b093399a123db2021-12-02T12:06:09ZAmniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application1178-6957https://doaj.org/article/ba0607bcfaa544598f1b093399a123db2014-03-01T00:00:00Zhttp://www.dovepress.com/amniotic-membrane-derived-stem-cells-immunomodulatory-properties-and-p-a16214https://doaj.org/toc/1178-6957 Carmen L Insausti,1 Miguel Blanquer,1 Ana M García-Hernández,1 Gregorio Castellanos,2 José M Moraleda11Unidad de Trasplante Hematopoyético y Terapia Celular, 2Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB, Campus Mare Nostrum, Universidad de Murcia, El Palmar, Murcia, SpainAbstract: Epithelial and mesenchymal cells isolated from the amniotic membrane (AM) possess stem cell characteristics, differentiation potential toward lineages of different germ layers, and immunomodulatory properties. While their expansion and differentiation potential have been well studied and characterized, knowledge about their immunomodulatory properties and the mechanisms involved is still incomplete. These mechanisms have been evaluated on various target cells of the innate and the adaptive system and in animal models of different inflammatory diseases. Some results have evidenced that the immunomodulatory effect of AM-derived cells is dependent on cell-cell contact, but many of them have demonstrated that these properties are mediated through the secretion of suppressive molecules. In this review, we present an update on the described immunomodulatory properties of the derived amniotic cells and some of the proposed involved mechanisms. Furthermore, we describe some assays in animal models of different inflammatory diseases which reveal the potential use of these cells to treat such diseases.Keywords: epithelial cells, mesenchymal cells, cell therapy, immunomodulationInsausti CLBlanquer MGarcía-Hernández AMCastellanos GMoraleda JMDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2014, Iss default, Pp 53-63 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Insausti CL Blanquer M García-Hernández AM Castellanos G Moraleda JM Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application
description	Carmen L Insausti,1 Miguel Blanquer,1 Ana M García-Hernández,1 Gregorio Castellanos,2 José M Moraleda11Unidad de Trasplante Hematopoyético y Terapia Celular, 2Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB, Campus Mare Nostrum, Universidad de Murcia, El Palmar, Murcia, SpainAbstract: Epithelial and mesenchymal cells isolated from the amniotic membrane (AM) possess stem cell characteristics, differentiation potential toward lineages of different germ layers, and immunomodulatory properties. While their expansion and differentiation potential have been well studied and characterized, knowledge about their immunomodulatory properties and the mechanisms involved is still incomplete. These mechanisms have been evaluated on various target cells of the innate and the adaptive system and in animal models of different inflammatory diseases. Some results have evidenced that the immunomodulatory effect of AM-derived cells is dependent on cell-cell contact, but many of them have demonstrated that these properties are mediated through the secretion of suppressive molecules. In this review, we present an update on the described immunomodulatory properties of the derived amniotic cells and some of the proposed involved mechanisms. Furthermore, we describe some assays in animal models of different inflammatory diseases which reveal the potential use of these cells to treat such diseases.Keywords: epithelial cells, mesenchymal cells, cell therapy, immunomodulation
format	article
author	Insausti CL Blanquer M García-Hernández AM Castellanos G Moraleda JM
author_facet	Insausti CL Blanquer M García-Hernández AM Castellanos G Moraleda JM
author_sort	Insausti CL
title	Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application
title_short	Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application
title_full	Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application
title_fullStr	Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application
title_full_unstemmed	Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application
title_sort	amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/ba0607bcfaa544598f1b093399a123db
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Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application

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