Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.

Subarachnoid hemorrhage (SAH) is a fatal stroke caused by bleeding in the brain. SAH can be caused by a ruptured aneurysm or head injury. One-third of patients will survive and recover. One-third will survive with disability; one-third will die. The focus of treatment is to stop bleeding, restore no...

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Autores principales:	Pengcheng Zhao, Shaonian Xu, Zhenshan Huang, Pengcheng Deng, Yongming Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba07e5a3fb234db6b0b99f5df507a34d
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spelling	oai:doaj.org-article:ba07e5a3fb234db6b0b99f5df507a34d2021-12-02T20:10:28ZIdentify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.1932-620310.1371/journal.pone.0253219https://doaj.org/article/ba07e5a3fb234db6b0b99f5df507a34d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253219https://doaj.org/toc/1932-6203Subarachnoid hemorrhage (SAH) is a fatal stroke caused by bleeding in the brain. SAH can be caused by a ruptured aneurysm or head injury. One-third of patients will survive and recover. One-third will survive with disability; one-third will die. The focus of treatment is to stop bleeding, restore normal blood flow, and prevent vasospasm. Treatment for SAH varies, depending on the bleeding's underlying cause and the extent of damage to the brain. Treatment may include lifesaving measures, symptom relief, repair of the bleeding vessel, and complication prevention. However, the useful diagnostic biomarkers of SAH are still limited due to the instability of gene marker expression. To overcome this limitation, we developed a new protocol pairing genes and screened significant gene pairs based on the feature selection algorithm. A classifier was constructed with the selected gene pairs and achieved a high performance.Pengcheng ZhaoShaonian XuZhenshan HuangPengcheng DengYongming ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253219 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pengcheng Zhao Shaonian Xu Zhenshan Huang Pengcheng Deng Yongming Zhang Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.
description	Subarachnoid hemorrhage (SAH) is a fatal stroke caused by bleeding in the brain. SAH can be caused by a ruptured aneurysm or head injury. One-third of patients will survive and recover. One-third will survive with disability; one-third will die. The focus of treatment is to stop bleeding, restore normal blood flow, and prevent vasospasm. Treatment for SAH varies, depending on the bleeding's underlying cause and the extent of damage to the brain. Treatment may include lifesaving measures, symptom relief, repair of the bleeding vessel, and complication prevention. However, the useful diagnostic biomarkers of SAH are still limited due to the instability of gene marker expression. To overcome this limitation, we developed a new protocol pairing genes and screened significant gene pairs based on the feature selection algorithm. A classifier was constructed with the selected gene pairs and achieved a high performance.
format	article
author	Pengcheng Zhao Shaonian Xu Zhenshan Huang Pengcheng Deng Yongming Zhang
author_facet	Pengcheng Zhao Shaonian Xu Zhenshan Huang Pengcheng Deng Yongming Zhang
author_sort	Pengcheng Zhao
title	Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.
title_short	Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.
title_full	Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.
title_fullStr	Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.
title_full_unstemmed	Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.
title_sort	identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ba07e5a3fb234db6b0b99f5df507a34d
work_keys_str_mv	AT pengchengzhao identifyspecificgenepairsforsubarachnoidhemorrhagebasedonwaveletanalysisandgeneticalgorithm AT shaonianxu identifyspecificgenepairsforsubarachnoidhemorrhagebasedonwaveletanalysisandgeneticalgorithm AT zhenshanhuang identifyspecificgenepairsforsubarachnoidhemorrhagebasedonwaveletanalysisandgeneticalgorithm AT pengchengdeng identifyspecificgenepairsforsubarachnoidhemorrhagebasedonwaveletanalysisandgeneticalgorithm AT yongmingzhang identifyspecificgenepairsforsubarachnoidhemorrhagebasedonwaveletanalysisandgeneticalgorithm
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Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.

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