Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells

Neurons can convert pathogenic T cells to anti-inflammatory FoxA1+ regulatory T cells (Tregs), which can ameliorate EAE, but the molecular mechanism is only partially understood. Liu et al. show that autocrine interferon β signalling induces PDL1 expression in neurons, which is essential for neurons...

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Autores principales:	Yawei Liu, Andrea Marin, Patrick Ejlerskov, Louise Munk Rasmussen, Marco Prinz, Shohreh Issazadeh-Navikas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ba089271c5bc48e1b485d5bb3165bf47
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spelling	oai:doaj.org-article:ba089271c5bc48e1b485d5bb3165bf472021-12-02T14:42:23ZNeuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells10.1038/ncomms147092041-1723https://doaj.org/article/ba089271c5bc48e1b485d5bb3165bf472017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14709https://doaj.org/toc/2041-1723Neurons can convert pathogenic T cells to anti-inflammatory FoxA1+ regulatory T cells (Tregs), which can ameliorate EAE, but the molecular mechanism is only partially understood. Liu et al. show that autocrine interferon β signalling induces PDL1 expression in neurons, which is essential for neurons to reprogramme pathogenic T cells to FoxA1+ Tregs.Yawei LiuAndrea MarinPatrick EjlerskovLouise Munk RasmussenMarco PrinzShohreh Issazadeh-NavikasNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yawei Liu Andrea Marin Patrick Ejlerskov Louise Munk Rasmussen Marco Prinz Shohreh Issazadeh-Navikas Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells
description	Neurons can convert pathogenic T cells to anti-inflammatory FoxA1+ regulatory T cells (Tregs), which can ameliorate EAE, but the molecular mechanism is only partially understood. Liu et al. show that autocrine interferon β signalling induces PDL1 expression in neurons, which is essential for neurons to reprogramme pathogenic T cells to FoxA1+ Tregs.
format	article
author	Yawei Liu Andrea Marin Patrick Ejlerskov Louise Munk Rasmussen Marco Prinz Shohreh Issazadeh-Navikas
author_facet	Yawei Liu Andrea Marin Patrick Ejlerskov Louise Munk Rasmussen Marco Prinz Shohreh Issazadeh-Navikas
author_sort	Yawei Liu
title	Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells
title_short	Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells
title_full	Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells
title_fullStr	Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells
title_full_unstemmed	Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells
title_sort	neuronal ifn-beta–induced pi3k/akt-foxa1 signalling is essential for generation of foxa1+treg cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ba089271c5bc48e1b485d5bb3165bf47
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Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells

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