ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS

Objective: To investigate the genotoxic effect of cigarette smoking in Sprague Dawley rats. Study Design: Randomized experimental study. Place and Duration of Study: Study was conducted at Army Medical College Rawalpindi, from Jan 2013 to Jul 2013. Material and Methods: Seventy healthy Spra...

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Autores principales:	Aneela Jamil, Amir Rashid, Abdul Khaliq Naveed
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	cigarette smoking genotoxicity Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ba0c22d53811433982933f69cbee242e
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spelling	oai:doaj.org-article:ba0c22d53811433982933f69cbee242e2021-11-12T03:30:28ZASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS0030-96482411-8842https://doaj.org/article/ba0c22d53811433982933f69cbee242e2019-06-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3030/2268https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To investigate the genotoxic effect of cigarette smoking in Sprague Dawley rats. Study Design: Randomized experimental study. Place and Duration of Study: Study was conducted at Army Medical College Rawalpindi, from Jan 2013 to Jul 2013. Material and Methods: Seventy healthy Sprague Dawley rats were randomly divided into two groups at National Institute of Health (NIH). Group-I rats were not exposed while Group-II rats were exposed to cigarette smoke for 3 months. Cytokinesis Block Micronucleus Assay (CBMN) was done to determine genotoxicity. Data were subjected to statistical analysis using independent sample t-test. Results: The mean frequency of micronuclei in peripheral blood lymphocytes of control and smoker groups was 3.06 ± 0.639 and 6.77 ± 0.731 respectively. The difference was not statistically significant (p>0.05). Conclusion: The mean micronuclei frequency in peripheral blood lymphocytes of the smoke exposed rats was higher than that of the control rats however the difference was not significant.Aneela JamilAmir RashidAbdul Khaliq NaveedArmy Medical College Rawalpindiarticlecigarette smokinggenotoxicityMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 3, Pp 577-581 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cigarette smoking genotoxicity Medicine R Medicine (General) R5-920
spellingShingle	cigarette smoking genotoxicity Medicine R Medicine (General) R5-920 Aneela Jamil Amir Rashid Abdul Khaliq Naveed ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS
description	Objective: To investigate the genotoxic effect of cigarette smoking in Sprague Dawley rats. Study Design: Randomized experimental study. Place and Duration of Study: Study was conducted at Army Medical College Rawalpindi, from Jan 2013 to Jul 2013. Material and Methods: Seventy healthy Sprague Dawley rats were randomly divided into two groups at National Institute of Health (NIH). Group-I rats were not exposed while Group-II rats were exposed to cigarette smoke for 3 months. Cytokinesis Block Micronucleus Assay (CBMN) was done to determine genotoxicity. Data were subjected to statistical analysis using independent sample t-test. Results: The mean frequency of micronuclei in peripheral blood lymphocytes of control and smoker groups was 3.06 ± 0.639 and 6.77 ± 0.731 respectively. The difference was not statistically significant (p>0.05). Conclusion: The mean micronuclei frequency in peripheral blood lymphocytes of the smoke exposed rats was higher than that of the control rats however the difference was not significant.
format	article
author	Aneela Jamil Amir Rashid Abdul Khaliq Naveed
author_facet	Aneela Jamil Amir Rashid Abdul Khaliq Naveed
author_sort	Aneela Jamil
title	ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS
title_short	ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS
title_full	ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS
title_fullStr	ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS
title_full_unstemmed	ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS
title_sort	assessment of smoke induced genotoxicity in sprague dawley rats
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/ba0c22d53811433982933f69cbee242e
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ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS

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