Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme

The nature of the ferryl intermediate generated in reactions catalysed by heme-containing enzymes is uncertain, due to the ambiguity of X-ray crystallography data. Here, the authors apply neutron diffraction, kinetics and other spectroscopy to directly observe a protonated ferryl intermediate in a h...

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Autores principales:	Hanna Kwon, Jaswir Basran, Cecilia M. Casadei, Alistair J. Fielding, Tobias E. Schrader, Andreas Ostermann, Juliette M. Devos, Pierre Aller, Matthew P. Blakeley, Peter C. E. Moody, Emma L. Raven
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ba0cf1877308498b991c38c8062c0431
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spelling	oai:doaj.org-article:ba0cf1877308498b991c38c8062c04312021-12-02T17:31:33ZDirect visualization of a Fe(IV)–OH intermediate in a heme enzyme10.1038/ncomms134452041-1723https://doaj.org/article/ba0cf1877308498b991c38c8062c04312016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13445https://doaj.org/toc/2041-1723The nature of the ferryl intermediate generated in reactions catalysed by heme-containing enzymes is uncertain, due to the ambiguity of X-ray crystallography data. Here, the authors apply neutron diffraction, kinetics and other spectroscopy to directly observe a protonated ferryl intermediate in a heme peroxidase.Hanna KwonJaswir BasranCecilia M. CasadeiAlistair J. FieldingTobias E. SchraderAndreas OstermannJuliette M. DevosPierre AllerMatthew P. BlakeleyPeter C. E. MoodyEmma L. RavenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hanna Kwon Jaswir Basran Cecilia M. Casadei Alistair J. Fielding Tobias E. Schrader Andreas Ostermann Juliette M. Devos Pierre Aller Matthew P. Blakeley Peter C. E. Moody Emma L. Raven Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme
description	The nature of the ferryl intermediate generated in reactions catalysed by heme-containing enzymes is uncertain, due to the ambiguity of X-ray crystallography data. Here, the authors apply neutron diffraction, kinetics and other spectroscopy to directly observe a protonated ferryl intermediate in a heme peroxidase.
format	article
author	Hanna Kwon Jaswir Basran Cecilia M. Casadei Alistair J. Fielding Tobias E. Schrader Andreas Ostermann Juliette M. Devos Pierre Aller Matthew P. Blakeley Peter C. E. Moody Emma L. Raven
author_facet	Hanna Kwon Jaswir Basran Cecilia M. Casadei Alistair J. Fielding Tobias E. Schrader Andreas Ostermann Juliette M. Devos Pierre Aller Matthew P. Blakeley Peter C. E. Moody Emma L. Raven
author_sort	Hanna Kwon
title	Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme
title_short	Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme
title_full	Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme
title_fullStr	Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme
title_full_unstemmed	Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme
title_sort	direct visualization of a fe(iv)–oh intermediate in a heme enzyme
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ba0cf1877308498b991c38c8062c0431
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Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme

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