Greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium

Theresa Raimondo, Sabrina Puckett, Thomas J WebsterSchool of Engineering and Department of Orthopedics, Brown University, Providence, RI, USAAbstract: Mostly due to desirable mechanical properties (such as high durability and low wear), certain synthetic polymers (such as polyethylene) and metals (s...

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Autores principales:	Theresa Raimondo, Sabrina Puckett, Thomas J Webster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ba1083fe0b514fbbb8e7504b89d0c5d8
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spelling	oai:doaj.org-article:ba1083fe0b514fbbb8e7504b89d0c5d82021-12-02T00:37:47ZGreater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium1176-91141178-2013https://doaj.org/article/ba1083fe0b514fbbb8e7504b89d0c5d82010-09-01T00:00:00Zhttp://www.dovepress.com/greater-osteoblast-and-endothelial-cell-adhesion-on-nanostructured-pol-a5204https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Theresa Raimondo, Sabrina Puckett, Thomas J WebsterSchool of Engineering and Department of Orthopedics, Brown University, Providence, RI, USAAbstract: Mostly due to desirable mechanical properties (such as high durability and low wear), certain synthetic polymers (such as polyethylene) and metals (such as titanium) have found numerous applications in the medical device arena from orthopedics to the vasculature, yet frequently, they do not proactively encourage desirable cell responses. In an effort to improve the efficacy of such traditional materials for various implant applications, this study used electron beam evaporation to create nanostructured surface features that mimic those of natural tissue on polyethylene and titanium. For other materials, it has been shown that the creation of nanorough surfaces increases surface energy leading to greater select protein (such as vitronectin and fibronectin) interactions to increase specific cell adhesion. Here, osteoblast (bone forming cells) and endothelial cell (cells that line the vasculature) adhesion was determined on nanostructured compared to conventional, nano-smooth polyethylene and titanium. Results demonstrated that nanorough surfaces created by electron beam evaporation increased the adhesion of both cells markedly better than conventional smooth surfaces. In summary, this study provided evidence that electron beam evaporation can modify implant surfaces (specifically, polyethylene and titanium) to have nanostructured surface features to improve osteoblast and endothelial cell adhesion. Since the adhesion of anchorage dependent cells (such as osteoblasts and endothelial cells) is a prerequisite for their long-term functions, this study suggests that electron beam evaporation should be further studied for improving materials for various biomedical applications. Keywords: nanotechnology, polyethylene, osteoblasts, orthopedics, vascular, titanium Theresa RaimondoSabrina PuckettThomas J WebsterDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 647-652 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Theresa Raimondo Sabrina Puckett Thomas J Webster Greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium
description	Theresa Raimondo, Sabrina Puckett, Thomas J WebsterSchool of Engineering and Department of Orthopedics, Brown University, Providence, RI, USAAbstract: Mostly due to desirable mechanical properties (such as high durability and low wear), certain synthetic polymers (such as polyethylene) and metals (such as titanium) have found numerous applications in the medical device arena from orthopedics to the vasculature, yet frequently, they do not proactively encourage desirable cell responses. In an effort to improve the efficacy of such traditional materials for various implant applications, this study used electron beam evaporation to create nanostructured surface features that mimic those of natural tissue on polyethylene and titanium. For other materials, it has been shown that the creation of nanorough surfaces increases surface energy leading to greater select protein (such as vitronectin and fibronectin) interactions to increase specific cell adhesion. Here, osteoblast (bone forming cells) and endothelial cell (cells that line the vasculature) adhesion was determined on nanostructured compared to conventional, nano-smooth polyethylene and titanium. Results demonstrated that nanorough surfaces created by electron beam evaporation increased the adhesion of both cells markedly better than conventional smooth surfaces. In summary, this study provided evidence that electron beam evaporation can modify implant surfaces (specifically, polyethylene and titanium) to have nanostructured surface features to improve osteoblast and endothelial cell adhesion. Since the adhesion of anchorage dependent cells (such as osteoblasts and endothelial cells) is a prerequisite for their long-term functions, this study suggests that electron beam evaporation should be further studied for improving materials for various biomedical applications. Keywords: nanotechnology, polyethylene, osteoblasts, orthopedics, vascular, titanium
format	article
author	Theresa Raimondo Sabrina Puckett Thomas J Webster
author_facet	Theresa Raimondo Sabrina Puckett Thomas J Webster
author_sort	Theresa Raimondo
title	Greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium
title_short	Greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium
title_full	Greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium
title_fullStr	Greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium
title_full_unstemmed	Greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium
title_sort	greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/ba1083fe0b514fbbb8e7504b89d0c5d8
work_keys_str_mv	AT theresaraimondo greaterosteoblastandendothelialcelladhesiononnanostructuredpolyethyleneandtitanium AT sabrinapuckett greaterosteoblastandendothelialcelladhesiononnanostructuredpolyethyleneandtitanium AT thomasjwebster greaterosteoblastandendothelialcelladhesiononnanostructuredpolyethyleneandtitanium
_version_	1718403578768392192

Greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium

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