Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics

Treating periodontitis with metronidazole (MET) as an adjunct to scaling root planing (SRP) is suggested to have inconsistent effects on insulin resistance (IR) in type 2 diabetes mellitus (T2DM). This paper will present the effects of MET, in addition to SRP, on the homeostatis model assessment of...

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Auteurs principaux:	Ambrina Qureshi, Zeba Haque, Hina Qureshi, Waqas Ahmed Farooqui
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	non-surgical periodontal therapy insulin resistance antibiotics type 2 diabetes mellitus clinical trial Therapeutics. Pharmacology RM1-950
Accès en ligne:	https://doaj.org/article/ba11145ec4eb4771a3e1f5d5b2667488
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spelling	oai:doaj.org-article:ba11145ec4eb4771a3e1f5d5b26674882021-11-25T16:24:46ZEffects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics10.3390/antibiotics101114002079-6382https://doaj.org/article/ba11145ec4eb4771a3e1f5d5b26674882021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1400https://doaj.org/toc/2079-6382Treating periodontitis with metronidazole (MET) as an adjunct to scaling root planing (SRP) is suggested to have inconsistent effects on insulin resistance (IR) in type 2 diabetes mellitus (T2DM). This paper will present the effects of MET, in addition to SRP, on the homeostatis model assessment of IR (HOMA-IR). A three-arm clinical trial was conducted and analyses were performed on T2DM participants with periodontitis (<i>n</i> = 74) who completed follow-up visits at 3 and 6 months after the intervention. The observed between-group and within-group mean changes in IR were found using ANOVA with repeated measures, followed by a post-hoc analysis, and a <i>p</i>-value of ≤0.05 was considered significant. Between-group analyses showed no difference in the HOMA-IR at 3 months, but at 6 months the difference was significant (<i>p</i> = 0.046). Within-group analyses showed that the HOMA-IR was significantly reduced in both test groups (<i>p</i> ≤ 0.05) over the period of time. Adjunct use of MET may result in a sudden short-term lowering of the HOMA-IR level within 3 months that may not be retained over 6 months when compared to the sustained lowering of the HOMA-IR levels in T2DM when intervened with SRP without MET.Ambrina QureshiZeba HaqueHina QureshiWaqas Ahmed FarooquiMDPI AGarticlenon-surgical periodontal therapyinsulin resistanceantibioticstype 2 diabetes mellitusclinical trialTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1400, p 1400 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-surgical periodontal therapy insulin resistance antibiotics type 2 diabetes mellitus clinical trial Therapeutics. Pharmacology RM1-950
spellingShingle	non-surgical periodontal therapy insulin resistance antibiotics type 2 diabetes mellitus clinical trial Therapeutics. Pharmacology RM1-950 Ambrina Qureshi Zeba Haque Hina Qureshi Waqas Ahmed Farooqui Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics
description	Treating periodontitis with metronidazole (MET) as an adjunct to scaling root planing (SRP) is suggested to have inconsistent effects on insulin resistance (IR) in type 2 diabetes mellitus (T2DM). This paper will present the effects of MET, in addition to SRP, on the homeostatis model assessment of IR (HOMA-IR). A three-arm clinical trial was conducted and analyses were performed on T2DM participants with periodontitis (<i>n</i> = 74) who completed follow-up visits at 3 and 6 months after the intervention. The observed between-group and within-group mean changes in IR were found using ANOVA with repeated measures, followed by a post-hoc analysis, and a <i>p</i>-value of ≤0.05 was considered significant. Between-group analyses showed no difference in the HOMA-IR at 3 months, but at 6 months the difference was significant (<i>p</i> = 0.046). Within-group analyses showed that the HOMA-IR was significantly reduced in both test groups (<i>p</i> ≤ 0.05) over the period of time. Adjunct use of MET may result in a sudden short-term lowering of the HOMA-IR level within 3 months that may not be retained over 6 months when compared to the sustained lowering of the HOMA-IR levels in T2DM when intervened with SRP without MET.
format	article
author	Ambrina Qureshi Zeba Haque Hina Qureshi Waqas Ahmed Farooqui
author_facet	Ambrina Qureshi Zeba Haque Hina Qureshi Waqas Ahmed Farooqui
author_sort	Ambrina Qureshi
title	Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics
title_short	Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics
title_full	Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics
title_fullStr	Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics
title_full_unstemmed	Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics
title_sort	effects of metronidazole as an adjunct to non-surgical periodontal therapy on insulin resistance in type 2 diabetics
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ba11145ec4eb4771a3e1f5d5b2667488
work_keys_str_mv	AT ambrinaqureshi effectsofmetronidazoleasanadjuncttononsurgicalperiodontaltherapyoninsulinresistanceintype2diabetics AT zebahaque effectsofmetronidazoleasanadjuncttononsurgicalperiodontaltherapyoninsulinresistanceintype2diabetics AT hinaqureshi effectsofmetronidazoleasanadjuncttononsurgicalperiodontaltherapyoninsulinresistanceintype2diabetics AT waqasahmedfarooqui effectsofmetronidazoleasanadjuncttononsurgicalperiodontaltherapyoninsulinresistanceintype2diabetics
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Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics

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