A fln-2 mutation affects lethal pathology and lifespan in C. elegans

C. elegans is a commonly used model organism in the study of ageing, and differences in genetic background can result in varying strain longevity. Here the authors demonstrate that a background mutation in fln-2 affects life-limiting pharyngeal infection and that in the mutant background the benefic...

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Autores principales:	Yuan Zhao, Hongyuan Wang, Richard J. Poole, David Gems
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ba1442fab90a48cc9477b561e6f96c6d
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spelling	oai:doaj.org-article:ba1442fab90a48cc9477b561e6f96c6d2021-12-02T14:39:36ZA fln-2 mutation affects lethal pathology and lifespan in C. elegans10.1038/s41467-019-13062-z2041-1723https://doaj.org/article/ba1442fab90a48cc9477b561e6f96c6d2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13062-zhttps://doaj.org/toc/2041-1723C. elegans is a commonly used model organism in the study of ageing, and differences in genetic background can result in varying strain longevity. Here the authors demonstrate that a background mutation in fln-2 affects life-limiting pharyngeal infection and that in the mutant background the beneficial effect of sir-2.1 over-expression is suppressed.Yuan ZhaoHongyuan WangRichard J. PooleDavid GemsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Zhao Hongyuan Wang Richard J. Poole David Gems A fln-2 mutation affects lethal pathology and lifespan in C. elegans
description	C. elegans is a commonly used model organism in the study of ageing, and differences in genetic background can result in varying strain longevity. Here the authors demonstrate that a background mutation in fln-2 affects life-limiting pharyngeal infection and that in the mutant background the beneficial effect of sir-2.1 over-expression is suppressed.
format	article
author	Yuan Zhao Hongyuan Wang Richard J. Poole David Gems
author_facet	Yuan Zhao Hongyuan Wang Richard J. Poole David Gems
author_sort	Yuan Zhao
title	A fln-2 mutation affects lethal pathology and lifespan in C. elegans
title_short	A fln-2 mutation affects lethal pathology and lifespan in C. elegans
title_full	A fln-2 mutation affects lethal pathology and lifespan in C. elegans
title_fullStr	A fln-2 mutation affects lethal pathology and lifespan in C. elegans
title_full_unstemmed	A fln-2 mutation affects lethal pathology and lifespan in C. elegans
title_sort	fln-2 mutation affects lethal pathology and lifespan in c. elegans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ba1442fab90a48cc9477b561e6f96c6d
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A fln-2 mutation affects lethal pathology and lifespan in C. elegans

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