Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions

Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appears to be critical for receptor activation, and pr...

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Autores principales:	Vladislav A. Lushpa, Marina V. Goncharuk, Cong Lin, Arthur O. Zalevsky, Irina A. Talyzina, Aleksandra P. Luginina, Daniil D. Vakhrameev, Mikhail B. Shevtsov, Sergey A. Goncharuk, Alexander S. Arseniev, Valentin I. Borshchevskiy, Xiaohui Wang, Konstantin S. Mineev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ba1903b9028f4b788d2c7b76bc761832
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spelling	oai:doaj.org-article:ba1903b9028f4b788d2c7b76bc7618322021-12-02T19:02:27ZModulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions10.1038/s42003-021-02532-02399-3642https://doaj.org/article/ba1903b9028f4b788d2c7b76bc7618322021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02532-0https://doaj.org/toc/2399-3642Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appears to be critical for receptor activation, and provide potential structures TLR1-TIR/Zn complex based on in silico data.Vladislav A. LushpaMarina V. GoncharukCong LinArthur O. ZalevskyIrina A. TalyzinaAleksandra P. LugininaDaniil D. VakhrameevMikhail B. ShevtsovSergey A. GoncharukAlexander S. ArsenievValentin I. BorshchevskiyXiaohui WangKonstantin S. MineevNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Vladislav A. Lushpa Marina V. Goncharuk Cong Lin Arthur O. Zalevsky Irina A. Talyzina Aleksandra P. Luginina Daniil D. Vakhrameev Mikhail B. Shevtsov Sergey A. Goncharuk Alexander S. Arseniev Valentin I. Borshchevskiy Xiaohui Wang Konstantin S. Mineev Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions
description	Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appears to be critical for receptor activation, and provide potential structures TLR1-TIR/Zn complex based on in silico data.
format	article
author	Vladislav A. Lushpa Marina V. Goncharuk Cong Lin Arthur O. Zalevsky Irina A. Talyzina Aleksandra P. Luginina Daniil D. Vakhrameev Mikhail B. Shevtsov Sergey A. Goncharuk Alexander S. Arseniev Valentin I. Borshchevskiy Xiaohui Wang Konstantin S. Mineev
author_facet	Vladislav A. Lushpa Marina V. Goncharuk Cong Lin Arthur O. Zalevsky Irina A. Talyzina Aleksandra P. Luginina Daniil D. Vakhrameev Mikhail B. Shevtsov Sergey A. Goncharuk Alexander S. Arseniev Valentin I. Borshchevskiy Xiaohui Wang Konstantin S. Mineev
author_sort	Vladislav A. Lushpa
title	Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions
title_short	Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions
title_full	Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions
title_fullStr	Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions
title_full_unstemmed	Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions
title_sort	modulation of toll-like receptor 1 intracellular domain structure and activity by zn2+ ions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ba1903b9028f4b788d2c7b76bc761832
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Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions

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