Parkinson’s disease-associated melanin steal
Marty Hinz,1 Alvin Stein,2 Ted Cole3 1Clinical Research, NeuroResearch Clinics, Inc., Cape Coral, FL, USA; 2Stein Orthopedic Associates, Plantation, FL, USA; 3Cole Center for Healing, Cincinnati, OH, USA Abstract: Urinary dopamine fluctuations in the competitive inhibition state were first docume...
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Dove Medical Press
2014
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oai:doaj.org-article:ba1b1a928f284aae90ddf8e2fdf6063f2021-12-02T03:45:06ZParkinson’s disease-associated melanin steal1178-2021https://doaj.org/article/ba1b1a928f284aae90ddf8e2fdf6063f2014-12-01T00:00:00Zhttp://www.dovepress.com/parkinsonrsquos-disease-associated-melanin-steal-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Marty Hinz,1 Alvin Stein,2 Ted Cole3 1Clinical Research, NeuroResearch Clinics, Inc., Cape Coral, FL, USA; 2Stein Orthopedic Associates, Plantation, FL, USA; 3Cole Center for Healing, Cincinnati, OH, USA Abstract: Urinary dopamine fluctuations in the competitive inhibition state were first documented in 2009. At that time, it was noted that progressively higher daily dosing values of L-tyrosine decreased the magnitude of these fluctuations. While extensive statistical analysis has been performed by the authors since 2004, it was not until 2012 that a plausible explanation was formulated. In the process, correlations with L-tyrosine administration and the on/off effect of Parkinson’s disease were defined. This paper documents the current knowledge with regard to the management of retrograde phase 1 dopamine fluctuations and investigates the hypothesis that they are caused by a melanin steal phenomenon. Keywords: fluctuations, L-dopa, dopamine, melanocyteHinz MStein ACole TDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 2331-2337 (2014) |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hinz M Stein A Cole T Parkinson’s disease-associated melanin steal |
| description |
Marty Hinz,1 Alvin Stein,2 Ted Cole3 1Clinical Research, NeuroResearch Clinics, Inc., Cape Coral, FL, USA; 2Stein Orthopedic Associates, Plantation, FL, USA; 3Cole Center for Healing, Cincinnati, OH, USA Abstract: Urinary dopamine fluctuations in the competitive inhibition state were first documented in 2009. At that time, it was noted that progressively higher daily dosing values of L-tyrosine decreased the magnitude of these fluctuations. While extensive statistical analysis has been performed by the authors since 2004, it was not until 2012 that a plausible explanation was formulated. In the process, correlations with L-tyrosine administration and the on/off effect of Parkinson’s disease were defined. This paper documents the current knowledge with regard to the management of retrograde phase 1 dopamine fluctuations and investigates the hypothesis that they are caused by a melanin steal phenomenon. Keywords: fluctuations, L-dopa, dopamine, melanocyte |
| format |
article |
| author |
Hinz M Stein A Cole T |
| author_facet |
Hinz M Stein A Cole T |
| author_sort |
Hinz M |
| title |
Parkinson’s disease-associated melanin steal |
| title_short |
Parkinson’s disease-associated melanin steal |
| title_full |
Parkinson’s disease-associated melanin steal |
| title_fullStr |
Parkinson’s disease-associated melanin steal |
| title_full_unstemmed |
Parkinson’s disease-associated melanin steal |
| title_sort |
parkinson’s disease-associated melanin steal |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/ba1b1a928f284aae90ddf8e2fdf6063f |
| work_keys_str_mv |
AT hinzm parkinsonrsquosdiseaseassociatedmelaninsteal AT steina parkinsonrsquosdiseaseassociatedmelaninsteal AT colet parkinsonrsquosdiseaseassociatedmelaninsteal |
| _version_ |
1718401643659132928 |