Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats

Abstract Closed-loop brain stimulation is a promising alternative to treat drug-resistant epilepsies. In contrast to optogenetic interventions, transcranial electrical stimulation (TES) does not require cellular modification of neurons to be effective, and it is less invasive compared to deep brain...

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Autores principales:	Gábor Kozák, Antal Berényi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba1b53c7216a40e88f47422958e67236
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spelling	oai:doaj.org-article:ba1b53c7216a40e88f47422958e672362021-12-02T15:04:55ZSustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats10.1038/s41598-017-06684-02045-2322https://doaj.org/article/ba1b53c7216a40e88f47422958e672362017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06684-0https://doaj.org/toc/2045-2322Abstract Closed-loop brain stimulation is a promising alternative to treat drug-resistant epilepsies. In contrast to optogenetic interventions, transcranial electrical stimulation (TES) does not require cellular modification of neurons to be effective, and it is less invasive compared to deep brain stimulation. Furthermore, on-demand TES of targeted brain regions allows the potential for normal function of these networks during interictal periods, a possibility that is eliminated by resective surgical treatment approaches. To further explore the translation of closed-loop TES for treatment of epilepsy, we show here for the first time that unsupervised closed-loop TES in rats can consistently interrupt seizures for 6 weeks and has the potential to control seizure activity up to 4 months (longest periods examined). On-demand TES significantly reduced the time spent in seizure and the individual seizure duration, although significantly higher seizure rate was observed during the treatment. The 6 week long stimulation had no residual adverse effects on the electrophysiologic characteristics of the brain after the termination of the treatment and did not induce glial remodelling in the brain. Our findings demonstrate the safety and effectiveness of minimally invasive, potentially lifelong TES treatment of epilepsy either alone or as a complement to drug treatments.Gábor KozákAntal BerényiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gábor Kozák Antal Berényi Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats
description	Abstract Closed-loop brain stimulation is a promising alternative to treat drug-resistant epilepsies. In contrast to optogenetic interventions, transcranial electrical stimulation (TES) does not require cellular modification of neurons to be effective, and it is less invasive compared to deep brain stimulation. Furthermore, on-demand TES of targeted brain regions allows the potential for normal function of these networks during interictal periods, a possibility that is eliminated by resective surgical treatment approaches. To further explore the translation of closed-loop TES for treatment of epilepsy, we show here for the first time that unsupervised closed-loop TES in rats can consistently interrupt seizures for 6 weeks and has the potential to control seizure activity up to 4 months (longest periods examined). On-demand TES significantly reduced the time spent in seizure and the individual seizure duration, although significantly higher seizure rate was observed during the treatment. The 6 week long stimulation had no residual adverse effects on the electrophysiologic characteristics of the brain after the termination of the treatment and did not induce glial remodelling in the brain. Our findings demonstrate the safety and effectiveness of minimally invasive, potentially lifelong TES treatment of epilepsy either alone or as a complement to drug treatments.
format	article
author	Gábor Kozák Antal Berényi
author_facet	Gábor Kozák Antal Berényi
author_sort	Gábor Kozák
title	Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats
title_short	Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats
title_full	Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats
title_fullStr	Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats
title_full_unstemmed	Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats
title_sort	sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ba1b53c7216a40e88f47422958e67236
work_keys_str_mv	AT gaborkozak sustainedefficacyofclosedloopelectricalstimulationforlongtermtreatmentofabsenceepilepsyinrats AT antalberenyi sustainedefficacyofclosedloopelectricalstimulationforlongtermtreatmentofabsenceepilepsyinrats
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Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats

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