Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.

<h4>Background</h4>Glucocorticoid has an important effect on lipid metabolism in muscles, and the type of fatty acid likely affects mitochondrial utilization. Therefore, we hypothesize that the different fatty acid types treatment may affect the glucocorticoid induction of intramuscular...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiao juan Wang, Dai lin Wei, Zhi gang Song, Hong chao Jiao, Hai Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba1d6617394a4809bf736b9de9c696b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ba1d6617394a4809bf736b9de9c696b0
record_format	dspace
spelling	oai:doaj.org-article:ba1d6617394a4809bf736b9de9c696b02021-11-18T07:18:14ZEffects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.1932-620310.1371/journal.pone.0036663https://doaj.org/article/ba1d6617394a4809bf736b9de9c696b02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22623960/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Glucocorticoid has an important effect on lipid metabolism in muscles, and the type of fatty acid likely affects mitochondrial utilization. Therefore, we hypothesize that the different fatty acid types treatment may affect the glucocorticoid induction of intramuscular lipid accumulation.<h4>Methodology/principal findings</h4>The effect of dexamethasone (DEX) on fatty acid metabolism and storage in skeletal muscle of broiler chickens (Gallus gallus domesticus) was investigated with and without fatty acid treatments. Male Arbor Acres chickens (31 d old) were treated with either palmitic acid (PA) or oleic acid (OA) for 7 days, followed by DEX administration for 3 days (35-37 d old). The DEX-induced lipid uptake and oxidation imbalance, which was estimated by increased fatty acid transport protein 1 (FATP1) expression and decreased carnitine palmitoyl transferase 1 activity, contributed to skeletal muscle lipid accumulation. More sensitive than glycolytic muscle, the oxidative muscle in DEX-treated chickens showed a decrease in the AMP to ATP ratio, a decrease in AMP-activated protein kinase (AMPK) alpha phosphorylation and its activity, as well as an increase in the phosphorylation of mammalian target of rapamycin (mTOR) and ribosomal p70S6 kinase, without Akt activation. DEX-stimulated lipid deposition was augmented by PA, but alleviated by OA, in response to pathways that were regulated differently, including AMPK, mTOR and FATP1.<h4>Conclusions</h4>DEX-induced intramuscular lipid accumulation was aggravated by SFA but alleviated by unsaturated fatty acid. The suppressed AMPK and augmented mTOR signaling pathways were involved in glucocortcoid-mediated enhanced intramuscular fat accumulation.Xiao juan WangDai lin WeiZhi gang SongHong chao JiaoHai LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e36663 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiao juan Wang Dai lin Wei Zhi gang Song Hong chao Jiao Hai Lin Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.
description	<h4>Background</h4>Glucocorticoid has an important effect on lipid metabolism in muscles, and the type of fatty acid likely affects mitochondrial utilization. Therefore, we hypothesize that the different fatty acid types treatment may affect the glucocorticoid induction of intramuscular lipid accumulation.<h4>Methodology/principal findings</h4>The effect of dexamethasone (DEX) on fatty acid metabolism and storage in skeletal muscle of broiler chickens (Gallus gallus domesticus) was investigated with and without fatty acid treatments. Male Arbor Acres chickens (31 d old) were treated with either palmitic acid (PA) or oleic acid (OA) for 7 days, followed by DEX administration for 3 days (35-37 d old). The DEX-induced lipid uptake and oxidation imbalance, which was estimated by increased fatty acid transport protein 1 (FATP1) expression and decreased carnitine palmitoyl transferase 1 activity, contributed to skeletal muscle lipid accumulation. More sensitive than glycolytic muscle, the oxidative muscle in DEX-treated chickens showed a decrease in the AMP to ATP ratio, a decrease in AMP-activated protein kinase (AMPK) alpha phosphorylation and its activity, as well as an increase in the phosphorylation of mammalian target of rapamycin (mTOR) and ribosomal p70S6 kinase, without Akt activation. DEX-stimulated lipid deposition was augmented by PA, but alleviated by OA, in response to pathways that were regulated differently, including AMPK, mTOR and FATP1.<h4>Conclusions</h4>DEX-induced intramuscular lipid accumulation was aggravated by SFA but alleviated by unsaturated fatty acid. The suppressed AMPK and augmented mTOR signaling pathways were involved in glucocortcoid-mediated enhanced intramuscular fat accumulation.
format	article
author	Xiao juan Wang Dai lin Wei Zhi gang Song Hong chao Jiao Hai Lin
author_facet	Xiao juan Wang Dai lin Wei Zhi gang Song Hong chao Jiao Hai Lin
author_sort	Xiao juan Wang
title	Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.
title_short	Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.
title_full	Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.
title_fullStr	Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.
title_full_unstemmed	Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.
title_sort	effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ba1d6617394a4809bf736b9de9c696b0
work_keys_str_mv	AT xiaojuanwang effectsoffattyacidtreatmentsonthedexamethasoneinducedintramuscularlipidaccumulationinchickens AT dailinwei effectsoffattyacidtreatmentsonthedexamethasoneinducedintramuscularlipidaccumulationinchickens AT zhigangsong effectsoffattyacidtreatmentsonthedexamethasoneinducedintramuscularlipidaccumulationinchickens AT hongchaojiao effectsoffattyacidtreatmentsonthedexamethasoneinducedintramuscularlipidaccumulationinchickens AT hailin effectsoffattyacidtreatmentsonthedexamethasoneinducedintramuscularlipidaccumulationinchickens
_version_	1718423689716826112

Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.

Ejemplares similares