Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus

Aim. To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. Method. In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm2 for 9...

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Autores principales:	Abdelrahman Salman, Taym Darwish, Marwan Ghabra, Obeda Kailani, Hussam Khalil, Rafea Shaaban
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ba1f4d961a004efd89ba46948160b076
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spelling	oai:doaj.org-article:ba1f4d961a004efd89ba46948160b0762021-11-29T00:56:38ZClinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus2090-005810.1155/2021/1851883https://doaj.org/article/ba1f4d961a004efd89ba46948160b0762021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1851883https://doaj.org/toc/2090-0058Aim. To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. Method. In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm2 for 9 minutes with a total dose of 5.4 J/cm2. Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow-up duration of 24 months were included in the study. Results. Mean ± standard deviation age was 15.41 ± 2.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56 ± 0.28 to 0.42 ± 0.29 logMAR P=0.0003, and corrected distance visual acuity improved significantly from 0.34 ± 0.23 to 0.28 ± 0.22 logMAR P=0.014. The mean manifest refraction spherical equivalent value was significantly reduced (−0.59 ± 0.95 D, P=0.0024). While mean flat keratometry and steep keratometry values were not significantly altered (P>0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97 ± 5.24 D preoperatively to 55.84 ± 5.37 D at 24 months postoperatively P=0.003. Maximum keratometry had progressed by >1 D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%). Conclusion. Our 24-month follow-up demonstrated that accelerated corneal cross-linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved.Abdelrahman SalmanTaym DarwishMarwan GhabraObeda KailaniHussam KhalilRafea ShaabanHindawi LimitedarticleOphthalmologyRE1-994ENJournal of Ophthalmology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Abdelrahman Salman Taym Darwish Marwan Ghabra Obeda Kailani Hussam Khalil Rafea Shaaban Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
description	Aim. To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. Method. In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm2 for 9 minutes with a total dose of 5.4 J/cm2. Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow-up duration of 24 months were included in the study. Results. Mean ± standard deviation age was 15.41 ± 2.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56 ± 0.28 to 0.42 ± 0.29 logMAR P=0.0003, and corrected distance visual acuity improved significantly from 0.34 ± 0.23 to 0.28 ± 0.22 logMAR P=0.014. The mean manifest refraction spherical equivalent value was significantly reduced (−0.59 ± 0.95 D, P=0.0024). While mean flat keratometry and steep keratometry values were not significantly altered (P>0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97 ± 5.24 D preoperatively to 55.84 ± 5.37 D at 24 months postoperatively P=0.003. Maximum keratometry had progressed by >1 D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%). Conclusion. Our 24-month follow-up demonstrated that accelerated corneal cross-linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved.
format	article
author	Abdelrahman Salman Taym Darwish Marwan Ghabra Obeda Kailani Hussam Khalil Rafea Shaaban
author_facet	Abdelrahman Salman Taym Darwish Marwan Ghabra Obeda Kailani Hussam Khalil Rafea Shaaban
author_sort	Abdelrahman Salman
title	Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_short	Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_full	Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_fullStr	Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_full_unstemmed	Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus
title_sort	clinical outcomes of accelerated corneal cross-linking for pediatric keratoconus
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/ba1f4d961a004efd89ba46948160b076
work_keys_str_mv	AT abdelrahmansalman clinicaloutcomesofacceleratedcornealcrosslinkingforpediatrickeratoconus AT taymdarwish clinicaloutcomesofacceleratedcornealcrosslinkingforpediatrickeratoconus AT marwanghabra clinicaloutcomesofacceleratedcornealcrosslinkingforpediatrickeratoconus AT obedakailani clinicaloutcomesofacceleratedcornealcrosslinkingforpediatrickeratoconus AT hussamkhalil clinicaloutcomesofacceleratedcornealcrosslinkingforpediatrickeratoconus AT rafeashaaban clinicaloutcomesofacceleratedcornealcrosslinkingforpediatrickeratoconus
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Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus

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