Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey

Abstract This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxic...

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Autores principales:	Julien Langrand-Escure, Peng Diao, Max-Adrien Garcia, Guoping Wang, Jean-Baptiste Guy, Sophie Espenel, Elodie Guillaume, Amel Rehailia-Blanchard, Grégoire Pigné, Guy de Laroche, David Kaczmarek, Thierry Muron, Jack Porcheron, Jean-Marc Phelip, Alexis Vallard, Nicolas Magné
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba1f95710e8b40e4b3ba3fc05ee9b3ae
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spelling	oai:doaj.org-article:ba1f95710e8b40e4b3ba3fc05ee9b3ae2021-12-02T15:07:58ZOutcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey10.1038/s41598-018-29040-22045-2322https://doaj.org/article/ba1f95710e8b40e4b3ba3fc05ee9b3ae2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29040-2https://doaj.org/toc/2045-2322Abstract This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxicity were retrospectively collected. Patients were diagnosed a non-metastatic rectal cancer between 2004 and 2015, and were treated at least with radiotherapy. OS was correlated with patient, tumor and treatment characteristics with univariate and multivariate analyses. Data of 593 consecutive non-metastatic rectal cancer patients were analyzed. Median follow-up was 41 months. Median OS was 9 years. Radiotherapy was delivered in pre-operative (n = 477, 80.5%), post-operative (n = 75, 12.6%) or exclusive (n = 41, 6.9%) setting. In the whole set of patients, age, nutritional condition, tumor stage, tumor differentiation, and surgery independently influenced OS. For patients experiencing surgery, OS was influenced by age, tumor differentiation and nodal status. Surgical resection is the cornerstone treatment for locally-advanced rectal cancer. Poor tumor differentiation and node involvement were identified as major predictive factor of poor OS. The research in treatment intensification and in identification of radioresistance biomarkers should therefore probably be focused on this particular subset of patients.Julien Langrand-EscurePeng DiaoMax-Adrien GarciaGuoping WangJean-Baptiste GuySophie EspenelElodie GuillaumeAmel Rehailia-BlanchardGrégoire PignéGuy de LarocheDavid KaczmarekThierry MuronJack PorcheronJean-Marc PhelipAlexis VallardNicolas MagnéNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julien Langrand-Escure Peng Diao Max-Adrien Garcia Guoping Wang Jean-Baptiste Guy Sophie Espenel Elodie Guillaume Amel Rehailia-Blanchard Grégoire Pigné Guy de Laroche David Kaczmarek Thierry Muron Jack Porcheron Jean-Marc Phelip Alexis Vallard Nicolas Magné Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey
description	Abstract This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxicity were retrospectively collected. Patients were diagnosed a non-metastatic rectal cancer between 2004 and 2015, and were treated at least with radiotherapy. OS was correlated with patient, tumor and treatment characteristics with univariate and multivariate analyses. Data of 593 consecutive non-metastatic rectal cancer patients were analyzed. Median follow-up was 41 months. Median OS was 9 years. Radiotherapy was delivered in pre-operative (n = 477, 80.5%), post-operative (n = 75, 12.6%) or exclusive (n = 41, 6.9%) setting. In the whole set of patients, age, nutritional condition, tumor stage, tumor differentiation, and surgery independently influenced OS. For patients experiencing surgery, OS was influenced by age, tumor differentiation and nodal status. Surgical resection is the cornerstone treatment for locally-advanced rectal cancer. Poor tumor differentiation and node involvement were identified as major predictive factor of poor OS. The research in treatment intensification and in identification of radioresistance biomarkers should therefore probably be focused on this particular subset of patients.
format	article
author	Julien Langrand-Escure Peng Diao Max-Adrien Garcia Guoping Wang Jean-Baptiste Guy Sophie Espenel Elodie Guillaume Amel Rehailia-Blanchard Grégoire Pigné Guy de Laroche David Kaczmarek Thierry Muron Jack Porcheron Jean-Marc Phelip Alexis Vallard Nicolas Magné
author_facet	Julien Langrand-Escure Peng Diao Max-Adrien Garcia Guoping Wang Jean-Baptiste Guy Sophie Espenel Elodie Guillaume Amel Rehailia-Blanchard Grégoire Pigné Guy de Laroche David Kaczmarek Thierry Muron Jack Porcheron Jean-Marc Phelip Alexis Vallard Nicolas Magné
author_sort	Julien Langrand-Escure
title	Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey
title_short	Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey
title_full	Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey
title_fullStr	Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey
title_full_unstemmed	Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey
title_sort	outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ba1f95710e8b40e4b3ba3fc05ee9b3ae
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Outcome and prognostic factors in 593 non-metastatic rectal cancer patients: a mono-institutional survey

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