Functional implications of B lymphocytes in the development of rheumatoid arthritis

B cells play a key role in regulating the immune system by producingantibodies, acting as antigen-presenting cells, providing support toother mononuclear cells, and contributing directly to inflammatorypathways. Accumulating evidence indicates that there is a disruptionof these regulated processes i...

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Autores principales:	Juan-Manuel Anaya, Luis Miguel Gómez, María-Carolina Páez Leal
Formato:	article
Lenguaje:	ES
Publicado:	Universidad Autonoma de Bucaramanga 2006
Materias:	B cells rheumatoid arthritis rheumatoid factor anti-cycliccitrullinated peptide antibodies (Anti-CCP) BAFF anti-CD20. Medicine R
Acceso en línea:	https://doaj.org/article/ba204019f8494ec19452279e57d8ddfb
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spelling	oai:doaj.org-article:ba204019f8494ec19452279e57d8ddfb2021-12-02T11:27:24ZFunctional implications of B lymphocytes in the development of rheumatoid arthritis0123-7047https://doaj.org/article/ba204019f8494ec19452279e57d8ddfb2006-04-01T00:00:00Zhttp://caribdis.unab.edu.co/pls/portal/docs/PAGE/REVISTAMEDUNAB/NUMEROSANTERIORES/REVISTA%209%201/PAG34_44.PDFhttps://doaj.org/toc/0123-7047B cells play a key role in regulating the immune system by producingantibodies, acting as antigen-presenting cells, providing support toother mononuclear cells, and contributing directly to inflammatorypathways. Accumulating evidence indicates that there is a disruptionof these regulated processes in the pathogenesis of autoimmunediseases, including rheumatoid arthritis (RA). In RA there is a chronic inflammation in the affected joints leading to the development of ectopic germinal centers. A micro-environment is established which supports B cell activation and differentiation. Plasma cells may develop which secrete autoantibodies of high affinity directly into the synovial tissue. As a result, antigen/antibody complex formation, the activation of the complement cascade and the stimulation of macrophages may contribute to the destruction of joints. B cells also play a pivotal role in the activation of synovial T cells and the induction of cytokine secretion. Finally, the success of B cell depletion therapy by using monoclonal antibodies against CD20 further emphasized the importance of B cells in the pathogenesis of RAJuan-Manuel AnayaLuis Miguel GómezMaría-Carolina Páez LealUniversidad Autonoma de BucaramangaarticleB cellsrheumatoid arthritisrheumatoid factoranti-cycliccitrullinated peptide antibodies (Anti-CCP)BAFFanti-CD20.MedicineRESMedUNAB, Vol 9, Iss 1, Pp 34-44 (2006)
institution	DOAJ
collection	DOAJ
language	ES
topic	B cells rheumatoid arthritis rheumatoid factor anti-cycliccitrullinated peptide antibodies (Anti-CCP) BAFF anti-CD20. Medicine R
spellingShingle	B cells rheumatoid arthritis rheumatoid factor anti-cycliccitrullinated peptide antibodies (Anti-CCP) BAFF anti-CD20. Medicine R Juan-Manuel Anaya Luis Miguel Gómez María-Carolina Páez Leal Functional implications of B lymphocytes in the development of rheumatoid arthritis
description	B cells play a key role in regulating the immune system by producingantibodies, acting as antigen-presenting cells, providing support toother mononuclear cells, and contributing directly to inflammatorypathways. Accumulating evidence indicates that there is a disruptionof these regulated processes in the pathogenesis of autoimmunediseases, including rheumatoid arthritis (RA). In RA there is a chronic inflammation in the affected joints leading to the development of ectopic germinal centers. A micro-environment is established which supports B cell activation and differentiation. Plasma cells may develop which secrete autoantibodies of high affinity directly into the synovial tissue. As a result, antigen/antibody complex formation, the activation of the complement cascade and the stimulation of macrophages may contribute to the destruction of joints. B cells also play a pivotal role in the activation of synovial T cells and the induction of cytokine secretion. Finally, the success of B cell depletion therapy by using monoclonal antibodies against CD20 further emphasized the importance of B cells in the pathogenesis of RA
format	article
author	Juan-Manuel Anaya Luis Miguel Gómez María-Carolina Páez Leal
author_facet	Juan-Manuel Anaya Luis Miguel Gómez María-Carolina Páez Leal
author_sort	Juan-Manuel Anaya
title	Functional implications of B lymphocytes in the development of rheumatoid arthritis
title_short	Functional implications of B lymphocytes in the development of rheumatoid arthritis
title_full	Functional implications of B lymphocytes in the development of rheumatoid arthritis
title_fullStr	Functional implications of B lymphocytes in the development of rheumatoid arthritis
title_full_unstemmed	Functional implications of B lymphocytes in the development of rheumatoid arthritis
title_sort	functional implications of b lymphocytes in the development of rheumatoid arthritis
publisher	Universidad Autonoma de Bucaramanga
publishDate	2006
url	https://doaj.org/article/ba204019f8494ec19452279e57d8ddfb
work_keys_str_mv	AT juanmanuelanaya functionalimplicationsofblymphocytesinthedevelopmentofrheumatoidarthritis AT luismiguelgomez functionalimplicationsofblymphocytesinthedevelopmentofrheumatoidarthritis AT mariacarolinapaezleal functionalimplicationsofblymphocytesinthedevelopmentofrheumatoidarthritis
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Functional implications of B lymphocytes in the development of rheumatoid arthritis

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