Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography

Yujie Shi,1,* Dong Peng,2,* Dan Wang,1 Zongmin Zhao,3 Binlong Chen,1 Bing He,1 Yukun Zhu,2 Kun Wang,2 Jie Tian,2 Qiang Zhang1 1Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People’s Rep...

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Autores principales:	Shi Y, Peng D, Wang D, Zhao Z, Chen B, He B, Zhu Y, Wang K, Tian J, Zhang Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	msot imaging swcnhox exposure routes biodistribution in vivo fate Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ba2102ba7f8b40beb276d40debaf7b73
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spelling	oai:doaj.org-article:ba2102ba7f8b40beb276d40debaf7b732021-12-02T04:40:56ZBiodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography1178-2013https://doaj.org/article/ba2102ba7f8b40beb276d40debaf7b732019-12-01T00:00:00Zhttps://www.dovepress.com/biodistribution-survey-of-oxidized-single-wall-carbon-nanohorns-follow-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yujie Shi,1,* Dong Peng,2,* Dan Wang,1 Zongmin Zhao,3 Binlong Chen,1 Bing He,1 Yukun Zhu,2 Kun Wang,2 Jie Tian,2 Qiang Zhang1 1Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People’s Republic of China; 2CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China; 3School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA*These authors contributed equally to this workCorrespondence: Jie TianCAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People’s Republic of ChinaTel +86-10-82618465Email tian@ieee.orgQiang ZhangBeijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People’s Republic of ChinaTel/Fax +86-10-82802791Email zqdodo@bjmu.edu.cnIntroduction: Though widely studied for biomedical applications, the lack of current systemic studies on the in vivo fate of single-walled carbon nanohorns (SWCNHs) largely restricts their further applications, as real-time monitoring of their biodistribution remains a big challenge. Here, we aim to customize a label-free multispectral optoacoustic tomography (MSOT) method and systematically survey the fate of oxidized SWCNHs (SWCNHox) following different exposure routes by whole body imaging.Methods: Mice were given a suspension of SWCNHox with an average size of 136.4 nm via four different administration routes, and then imaged by MSOT.Results: After oral gavage, SWCNHox were mainly distributed in the gastrointestinal tract then excreted through the gut. Compared with the observation post first dosing, the accumulation of SWCNHox in the gastrointestinal tract was not obvious even after four-time oral gavage. Almost no SWCNHox were found at detectable levels in kidney, liver, blood and spleen. Following intravenous (iv) injection, SWCNHox were mainly presented and persisted in the spleen and liver, while very little in the kidney and almost none detectable in the intestine. SWCNHox accumulated significantly in the liver and spleen after four IV administrations. Following hypodermic and intramuscular injections, almost no SWCNHox could cross biological barriers and transport to the spleen, kidney or liver, likely due to their very low absorption rate. Almost all SWCNHox remained around the injection sites. For the first time, we have systematically investigated the in vivo fate of SWCNHs in a label-free and real-time manner.Conclusion: The findings of this study provide insights into the selection of appropriate exposure routes for potential biomedical applications of carbon nanomaterials.Keywords: MSOT imaging, SWCNHox, exposure routes, biodistribution, in vivo fateShi YPeng DWang DZhao ZChen BHe BZhu YWang KTian JZhang QDove Medical Pressarticlemsot imagingswcnhoxexposure routesbiodistributionin vivo fateMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 9809-9821 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	msot imaging swcnhox exposure routes biodistribution in vivo fate Medicine (General) R5-920
spellingShingle	msot imaging swcnhox exposure routes biodistribution in vivo fate Medicine (General) R5-920 Shi Y Peng D Wang D Zhao Z Chen B He B Zhu Y Wang K Tian J Zhang Q Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography
description	Yujie Shi,1,* Dong Peng,2,* Dan Wang,1 Zongmin Zhao,3 Binlong Chen,1 Bing He,1 Yukun Zhu,2 Kun Wang,2 Jie Tian,2 Qiang Zhang1 1Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People’s Republic of China; 2CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China; 3School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA*These authors contributed equally to this workCorrespondence: Jie TianCAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People’s Republic of ChinaTel +86-10-82618465Email tian@ieee.orgQiang ZhangBeijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People’s Republic of ChinaTel/Fax +86-10-82802791Email zqdodo@bjmu.edu.cnIntroduction: Though widely studied for biomedical applications, the lack of current systemic studies on the in vivo fate of single-walled carbon nanohorns (SWCNHs) largely restricts their further applications, as real-time monitoring of their biodistribution remains a big challenge. Here, we aim to customize a label-free multispectral optoacoustic tomography (MSOT) method and systematically survey the fate of oxidized SWCNHs (SWCNHox) following different exposure routes by whole body imaging.Methods: Mice were given a suspension of SWCNHox with an average size of 136.4 nm via four different administration routes, and then imaged by MSOT.Results: After oral gavage, SWCNHox were mainly distributed in the gastrointestinal tract then excreted through the gut. Compared with the observation post first dosing, the accumulation of SWCNHox in the gastrointestinal tract was not obvious even after four-time oral gavage. Almost no SWCNHox were found at detectable levels in kidney, liver, blood and spleen. Following intravenous (iv) injection, SWCNHox were mainly presented and persisted in the spleen and liver, while very little in the kidney and almost none detectable in the intestine. SWCNHox accumulated significantly in the liver and spleen after four IV administrations. Following hypodermic and intramuscular injections, almost no SWCNHox could cross biological barriers and transport to the spleen, kidney or liver, likely due to their very low absorption rate. Almost all SWCNHox remained around the injection sites. For the first time, we have systematically investigated the in vivo fate of SWCNHs in a label-free and real-time manner.Conclusion: The findings of this study provide insights into the selection of appropriate exposure routes for potential biomedical applications of carbon nanomaterials.Keywords: MSOT imaging, SWCNHox, exposure routes, biodistribution, in vivo fate
format	article
author	Shi Y Peng D Wang D Zhao Z Chen B He B Zhu Y Wang K Tian J Zhang Q
author_facet	Shi Y Peng D Wang D Zhao Z Chen B He B Zhu Y Wang K Tian J Zhang Q
author_sort	Shi Y
title	Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography
title_short	Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography
title_full	Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography
title_fullStr	Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography
title_full_unstemmed	Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography
title_sort	biodistribution survey of oxidized single-wall carbon nanohorns following different administration routes by using label-free multispectral optoacoustic tomography
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/ba2102ba7f8b40beb276d40debaf7b73
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Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography

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