Locoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation

Liver transplantation (LT) is the first-line treatment for patients diagnosed with unresectable early-stage hepatocellular carcinoma (HCC) in the setting of cirrhosis. It is well known that HCC patients within the Milan criteria (solitary tumour ≤ 5 cm or ≤3 tumours, each <3 cm) could undergo LT...

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Autores principales:	Laura Crocetti, Elena Bozzi, Paola Scalise, Irene Bargellini, Giulia Lorenzoni, Davide Ghinolfi, Daniela Campani, Emanuele Balzano, Paolo De Simone, Roberto Cioni
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma liver transplantation loco-regional therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ba216df0ef22481fab4d91997a20e7e0
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spelling	oai:doaj.org-article:ba216df0ef22481fab4d91997a20e7e02021-11-11T15:34:58ZLocoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation10.3390/cancers132155582072-6694https://doaj.org/article/ba216df0ef22481fab4d91997a20e7e02021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5558https://doaj.org/toc/2072-6694Liver transplantation (LT) is the first-line treatment for patients diagnosed with unresectable early-stage hepatocellular carcinoma (HCC) in the setting of cirrhosis. It is well known that HCC patients within the Milan criteria (solitary tumour ≤ 5 cm or ≤3 tumours, each <3 cm) could undergo LT with excellent results. However, there is a growing tendency to enlarge inclusion criteria since the Milan criteria are nowadays considered too restrictive and may exclude patients who would benefit from LT. On the other hand, there is a persistent shortage of donor organs. In this scenario, there is consensus about the role of loco-regional therapy (LRT) during the waiting list to select patients who would benefit more from LT, reducing the risk of drop off from the waiting list as well as decreasing tumour dimension to meet acceptable criteria for LT. In this review, current evidence on the safety, efficacy and utility of LRTs as neoadjuvant therapies before LT are summarized.Laura CrocettiElena BozziPaola ScaliseIrene BargelliniGiulia LorenzoniDavide GhinolfiDaniela CampaniEmanuele BalzanoPaolo De SimoneRoberto CioniMDPI AGarticlehepatocellular carcinomaliver transplantationloco-regional therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5558, p 5558 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma liver transplantation loco-regional therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma liver transplantation loco-regional therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Laura Crocetti Elena Bozzi Paola Scalise Irene Bargellini Giulia Lorenzoni Davide Ghinolfi Daniela Campani Emanuele Balzano Paolo De Simone Roberto Cioni Locoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation
description	Liver transplantation (LT) is the first-line treatment for patients diagnosed with unresectable early-stage hepatocellular carcinoma (HCC) in the setting of cirrhosis. It is well known that HCC patients within the Milan criteria (solitary tumour ≤ 5 cm or ≤3 tumours, each <3 cm) could undergo LT with excellent results. However, there is a growing tendency to enlarge inclusion criteria since the Milan criteria are nowadays considered too restrictive and may exclude patients who would benefit from LT. On the other hand, there is a persistent shortage of donor organs. In this scenario, there is consensus about the role of loco-regional therapy (LRT) during the waiting list to select patients who would benefit more from LT, reducing the risk of drop off from the waiting list as well as decreasing tumour dimension to meet acceptable criteria for LT. In this review, current evidence on the safety, efficacy and utility of LRTs as neoadjuvant therapies before LT are summarized.
format	article
author	Laura Crocetti Elena Bozzi Paola Scalise Irene Bargellini Giulia Lorenzoni Davide Ghinolfi Daniela Campani Emanuele Balzano Paolo De Simone Roberto Cioni
author_facet	Laura Crocetti Elena Bozzi Paola Scalise Irene Bargellini Giulia Lorenzoni Davide Ghinolfi Daniela Campani Emanuele Balzano Paolo De Simone Roberto Cioni
author_sort	Laura Crocetti
title	Locoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation
title_short	Locoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation
title_full	Locoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation
title_fullStr	Locoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation
title_full_unstemmed	Locoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation
title_sort	locoregional treatments for bridging and downstaging hcc to liver transplantation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ba216df0ef22481fab4d91997a20e7e0
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Locoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation

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