Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex

Somatosensory hypersensitivity in Fmr-1 knockout mice is thought to arise from an increase in cortical circuit excitability. Here, the authors report that the loss of precision of sensory encoding in the Layer 4 of barrel cortex is the primary developmental circuit alteration that drives the other c...

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Autores principales:	Aleksander P. F. Domanski, Sam A. Booker, David J. A. Wyllie, John T. R. Isaac, Peter C. Kind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ba220841587e4c75bd2141b3e2677e5b
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spelling	oai:doaj.org-article:ba220841587e4c75bd2141b3e2677e5b2021-12-02T17:32:24ZCellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex10.1038/s41467-019-12736-y2041-1723https://doaj.org/article/ba220841587e4c75bd2141b3e2677e5b2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12736-yhttps://doaj.org/toc/2041-1723Somatosensory hypersensitivity in Fmr-1 knockout mice is thought to arise from an increase in cortical circuit excitability. Here, the authors report that the loss of precision of sensory encoding in the Layer 4 of barrel cortex is the primary developmental circuit alteration that drives the other compensatory circuit dysfunction.Aleksander P. F. DomanskiSam A. BookerDavid J. A. WyllieJohn T. R. IsaacPeter C. KindNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aleksander P. F. Domanski Sam A. Booker David J. A. Wyllie John T. R. Isaac Peter C. Kind Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
description	Somatosensory hypersensitivity in Fmr-1 knockout mice is thought to arise from an increase in cortical circuit excitability. Here, the authors report that the loss of precision of sensory encoding in the Layer 4 of barrel cortex is the primary developmental circuit alteration that drives the other compensatory circuit dysfunction.
format	article
author	Aleksander P. F. Domanski Sam A. Booker David J. A. Wyllie John T. R. Isaac Peter C. Kind
author_facet	Aleksander P. F. Domanski Sam A. Booker David J. A. Wyllie John T. R. Isaac Peter C. Kind
author_sort	Aleksander P. F. Domanski
title	Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
title_short	Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
title_full	Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
title_fullStr	Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
title_full_unstemmed	Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
title_sort	cellular and synaptic phenotypes lead to disrupted information processing in fmr1-ko mouse layer 4 barrel cortex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ba220841587e4c75bd2141b3e2677e5b
work_keys_str_mv	AT aleksanderpfdomanski cellularandsynapticphenotypesleadtodisruptedinformationprocessinginfmr1komouselayer4barrelcortex AT samabooker cellularandsynapticphenotypesleadtodisruptedinformationprocessinginfmr1komouselayer4barrelcortex AT davidjawyllie cellularandsynapticphenotypesleadtodisruptedinformationprocessinginfmr1komouselayer4barrelcortex AT johntrisaac cellularandsynapticphenotypesleadtodisruptedinformationprocessinginfmr1komouselayer4barrelcortex AT peterckind cellularandsynapticphenotypesleadtodisruptedinformationprocessinginfmr1komouselayer4barrelcortex
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Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex

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