Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients

Abstract Rapid iodine-131(131I) turnover in the thyroid gland is an important feature of Graves’ disease (GD) and also a strong predictor of radioiodine therapy failure. The aim of this study was to explore the predictors of rapid 131I turnover. The clinical data on 2543 patients were retrospectivel...

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Autores principales:	Ruiguo Zhang, Jian Tan, Renfei Wang, Guizhi Zhang, Qiang Jia, Zhaowei Meng, Yueqian Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba226b8837c7421fa08a5c7c9d4aa19c
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spelling	oai:doaj.org-article:ba226b8837c7421fa08a5c7c9d4aa19c2021-12-02T12:30:13ZAnalysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients10.1038/s41598-017-08475-z2045-2322https://doaj.org/article/ba226b8837c7421fa08a5c7c9d4aa19c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08475-zhttps://doaj.org/toc/2045-2322Abstract Rapid iodine-131(131I) turnover in the thyroid gland is an important feature of Graves’ disease (GD) and also a strong predictor of radioiodine therapy failure. The aim of this study was to explore the predictors of rapid 131I turnover. The clinical data on 2543 patients were retrospectively reviewed. Patients were divided into 2 groups depending on present or absent with rapid 131I turnover defined as a 4-hour to 24-hour 131I uptake ratio of ≥1. Overall, 590 cases (23.2%) had a rapid 131I turnover. In the univariate analysis, gender, age, FT3/FT4 concentration, disease duration, with or without antithyroid drugs (ATD), time of ATD, thyroid weight and thyroid textures displayed significant differences. Cutoff values of age, FT3 and thyroid weight to predict rapid 131I turnover were 38 years, 35 pmol/l and 56 g by receiver operating characteristic curves. Binary logistic regression analysis further revealed higher probability of rapid 131I turnover in patients with thyroid weight ≥56 g (odds ratio [OR]:3.7, 95% confidence interval [CI]: 3.032–4.559), age <38 years (OR:2.3, 95%CI: 1.906–2.856), FT3 concentration ≥35 pmol/l (OR:7.6, 95%CI: 5.857–8.563) and females (OR:2.2, 95%CI: 1.757–2.791). In conclusion, larger goiters, younger age, higher FT3 concentration and females are independently associated with rapid 131I turnover in GD patients.Ruiguo ZhangJian TanRenfei WangGuizhi ZhangQiang JiaZhaowei MengYueqian ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruiguo Zhang Jian Tan Renfei Wang Guizhi Zhang Qiang Jia Zhaowei Meng Yueqian Zhang Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients
description	Abstract Rapid iodine-131(131I) turnover in the thyroid gland is an important feature of Graves’ disease (GD) and also a strong predictor of radioiodine therapy failure. The aim of this study was to explore the predictors of rapid 131I turnover. The clinical data on 2543 patients were retrospectively reviewed. Patients were divided into 2 groups depending on present or absent with rapid 131I turnover defined as a 4-hour to 24-hour 131I uptake ratio of ≥1. Overall, 590 cases (23.2%) had a rapid 131I turnover. In the univariate analysis, gender, age, FT3/FT4 concentration, disease duration, with or without antithyroid drugs (ATD), time of ATD, thyroid weight and thyroid textures displayed significant differences. Cutoff values of age, FT3 and thyroid weight to predict rapid 131I turnover were 38 years, 35 pmol/l and 56 g by receiver operating characteristic curves. Binary logistic regression analysis further revealed higher probability of rapid 131I turnover in patients with thyroid weight ≥56 g (odds ratio [OR]:3.7, 95% confidence interval [CI]: 3.032–4.559), age <38 years (OR:2.3, 95%CI: 1.906–2.856), FT3 concentration ≥35 pmol/l (OR:7.6, 95%CI: 5.857–8.563) and females (OR:2.2, 95%CI: 1.757–2.791). In conclusion, larger goiters, younger age, higher FT3 concentration and females are independently associated with rapid 131I turnover in GD patients.
format	article
author	Ruiguo Zhang Jian Tan Renfei Wang Guizhi Zhang Qiang Jia Zhaowei Meng Yueqian Zhang
author_facet	Ruiguo Zhang Jian Tan Renfei Wang Guizhi Zhang Qiang Jia Zhaowei Meng Yueqian Zhang
author_sort	Ruiguo Zhang
title	Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients
title_short	Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients
title_full	Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients
title_fullStr	Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients
title_full_unstemmed	Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients
title_sort	analysis of risk factors of rapid thyroidal radioiodine-131 turnover in graves’ disease patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ba226b8837c7421fa08a5c7c9d4aa19c
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Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients

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