Inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability

Abstract Perceptual organisation must select one interpretation from several alternatives to guide behaviour. Computational models suggest that this could be achieved through an interplay between inhibition and excitation across competing types of neural population coding for each interpretation. He...

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Autores principales:	Hirohito M. Kondo, Daniel Pressnitzer, Yasuhiro Shimada, Takanori Kochiyama, Makio Kashino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Volitional Control Excitatory-inhibitory Balance Duration Perception Longer Perception Perceptual Organization Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba23072d8bd14f6bba7f4b19243849de
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spelling	oai:doaj.org-article:ba23072d8bd14f6bba7f4b19243849de2021-12-02T11:40:46ZInhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability10.1038/s41598-018-32892-32045-2322https://doaj.org/article/ba23072d8bd14f6bba7f4b19243849de2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32892-3https://doaj.org/toc/2045-2322Abstract Perceptual organisation must select one interpretation from several alternatives to guide behaviour. Computational models suggest that this could be achieved through an interplay between inhibition and excitation across competing types of neural population coding for each interpretation. Here, to test for such models, we used magnetic resonance spectroscopy to measure non-invasively the concentrations of inhibitory γ-aminobutyric acid (GABA) and excitatory glutamate-glutamine (Glx) in several brain regions. Human participants first performed auditory and visual multistability tasks that produced spontaneous switching between percepts. Then, we observed that longer percept durations during behaviour were associated with higher GABA/Glx ratios in the sensory area coding for each modality. When participants were asked to voluntarily modulate their perception, a common factor across modalities emerged: the GABA/Glx ratio in the posterior parietal cortex tended to be positively correlated with the amount of effective volitional control. Our results provide direct evidence implicating that the balance between neural inhibition and excitation within sensory regions resolves perceptual competition. This powerful computational principle appears to be leveraged by both audition and vision, implemented independently across modalities, but modulated by an integrated control process.Hirohito M. KondoDaniel PressnitzerYasuhiro ShimadaTakanori KochiyamaMakio KashinoNature PortfolioarticleVolitional ControlExcitatory-inhibitory BalanceDuration PerceptionLonger PerceptionPerceptual OrganizationMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Volitional Control Excitatory-inhibitory Balance Duration Perception Longer Perception Perceptual Organization Medicine R Science Q
spellingShingle	Volitional Control Excitatory-inhibitory Balance Duration Perception Longer Perception Perceptual Organization Medicine R Science Q Hirohito M. Kondo Daniel Pressnitzer Yasuhiro Shimada Takanori Kochiyama Makio Kashino Inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability
description	Abstract Perceptual organisation must select one interpretation from several alternatives to guide behaviour. Computational models suggest that this could be achieved through an interplay between inhibition and excitation across competing types of neural population coding for each interpretation. Here, to test for such models, we used magnetic resonance spectroscopy to measure non-invasively the concentrations of inhibitory γ-aminobutyric acid (GABA) and excitatory glutamate-glutamine (Glx) in several brain regions. Human participants first performed auditory and visual multistability tasks that produced spontaneous switching between percepts. Then, we observed that longer percept durations during behaviour were associated with higher GABA/Glx ratios in the sensory area coding for each modality. When participants were asked to voluntarily modulate their perception, a common factor across modalities emerged: the GABA/Glx ratio in the posterior parietal cortex tended to be positively correlated with the amount of effective volitional control. Our results provide direct evidence implicating that the balance between neural inhibition and excitation within sensory regions resolves perceptual competition. This powerful computational principle appears to be leveraged by both audition and vision, implemented independently across modalities, but modulated by an integrated control process.
format	article
author	Hirohito M. Kondo Daniel Pressnitzer Yasuhiro Shimada Takanori Kochiyama Makio Kashino
author_facet	Hirohito M. Kondo Daniel Pressnitzer Yasuhiro Shimada Takanori Kochiyama Makio Kashino
author_sort	Hirohito M. Kondo
title	Inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability
title_short	Inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability
title_full	Inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability
title_fullStr	Inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability
title_full_unstemmed	Inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability
title_sort	inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ba23072d8bd14f6bba7f4b19243849de
work_keys_str_mv	AT hirohitomkondo inhibitionexcitationbalanceintheparietalcortexmodulatesvolitionalcontrolforauditoryandvisualmultistability AT danielpressnitzer inhibitionexcitationbalanceintheparietalcortexmodulatesvolitionalcontrolforauditoryandvisualmultistability AT yasuhiroshimada inhibitionexcitationbalanceintheparietalcortexmodulatesvolitionalcontrolforauditoryandvisualmultistability AT takanorikochiyama inhibitionexcitationbalanceintheparietalcortexmodulatesvolitionalcontrolforauditoryandvisualmultistability AT makiokashino inhibitionexcitationbalanceintheparietalcortexmodulatesvolitionalcontrolforauditoryandvisualmultistability
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Inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability

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