Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

HIV-1 usually targets active genes and integrates near the nuclear pore compartment. Here the authors show that recurrently targeted genes are proximal to super-enhancer genomic elements, which cluster in specific spatial compartments of the T cell nucleus, suggesting a role for nuclear organisation...

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Autores principales:	Bojana Lucic, Heng-Chang Chen, Maja Kuzman, Eduard Zorita, Julia Wegner, Vera Minneker, Wei Wang, Raffaele Fronza, Stefanie Laufs, Manfred Schmidt, Ralph Stadhouders, Vassilis Roukos, Kristian Vlahovicek, Guillaume J. Filion, Marina Lusic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ba25bfe3536b45a1a6e80271dcdd382b
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spelling	oai:doaj.org-article:ba25bfe3536b45a1a6e80271dcdd382b2021-12-02T14:38:47ZSpatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration10.1038/s41467-019-12046-32041-1723https://doaj.org/article/ba25bfe3536b45a1a6e80271dcdd382b2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12046-3https://doaj.org/toc/2041-1723HIV-1 usually targets active genes and integrates near the nuclear pore compartment. Here the authors show that recurrently targeted genes are proximal to super-enhancer genomic elements, which cluster in specific spatial compartments of the T cell nucleus, suggesting a role for nuclear organisation in viral infection.Bojana LucicHeng-Chang ChenMaja KuzmanEduard ZoritaJulia WegnerVera MinnekerWei WangRaffaele FronzaStefanie LaufsManfred SchmidtRalph StadhoudersVassilis RoukosKristian VlahovicekGuillaume J. FilionMarina LusicNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bojana Lucic Heng-Chang Chen Maja Kuzman Eduard Zorita Julia Wegner Vera Minneker Wei Wang Raffaele Fronza Stefanie Laufs Manfred Schmidt Ralph Stadhouders Vassilis Roukos Kristian Vlahovicek Guillaume J. Filion Marina Lusic Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration
description	HIV-1 usually targets active genes and integrates near the nuclear pore compartment. Here the authors show that recurrently targeted genes are proximal to super-enhancer genomic elements, which cluster in specific spatial compartments of the T cell nucleus, suggesting a role for nuclear organisation in viral infection.
format	article
author	Bojana Lucic Heng-Chang Chen Maja Kuzman Eduard Zorita Julia Wegner Vera Minneker Wei Wang Raffaele Fronza Stefanie Laufs Manfred Schmidt Ralph Stadhouders Vassilis Roukos Kristian Vlahovicek Guillaume J. Filion Marina Lusic
author_facet	Bojana Lucic Heng-Chang Chen Maja Kuzman Eduard Zorita Julia Wegner Vera Minneker Wei Wang Raffaele Fronza Stefanie Laufs Manfred Schmidt Ralph Stadhouders Vassilis Roukos Kristian Vlahovicek Guillaume J. Filion Marina Lusic
author_sort	Bojana Lucic
title	Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration
title_short	Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration
title_full	Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration
title_fullStr	Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration
title_full_unstemmed	Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration
title_sort	spatially clustered loci with multiple enhancers are frequent targets of hiv-1 integration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ba25bfe3536b45a1a6e80271dcdd382b
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Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

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