Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

HIV-1 usually targets active genes and integrates near the nuclear pore compartment. Here the authors show that recurrently targeted genes are proximal to super-enhancer genomic elements, which cluster in specific spatial compartments of the T cell nucleus, suggesting a role for nuclear organisation...

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Bibliographic Details
Main Authors: Bojana Lucic, Heng-Chang Chen, Maja Kuzman, Eduard Zorita, Julia Wegner, Vera Minneker, Wei Wang, Raffaele Fronza, Stefanie Laufs, Manfred Schmidt, Ralph Stadhouders, Vassilis Roukos, Kristian Vlahovicek, Guillaume J. Filion, Marina Lusic
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/ba25bfe3536b45a1a6e80271dcdd382b
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