Adipose expression of CREB3L3 modulates body weight during obesity

Abstract We found the hepatic transcription factor Cyclic-AMP Responsive Element Binding Protein 3-like-3 (CREB3L3) to be expressed in adipose tissue, and selectively downregulated in the more metabolically protective subcutaneous adipose tissue in obese mice and humans. We sought to elucidate the s...

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Autores principales:	Maximilian A. McCann, Yanliang Li, Marcos Muñoz, Victoria Gil, Guifen Qiang, Jose Cordoba-Chacon, Matthias Blüher, Stephen Duncan, Chong Wee Liew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba282b53acb742e59a203873b579f767
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spelling	oai:doaj.org-article:ba282b53acb742e59a203873b579f7672021-12-02T19:17:04ZAdipose expression of CREB3L3 modulates body weight during obesity10.1038/s41598-021-98627-z2045-2322https://doaj.org/article/ba282b53acb742e59a203873b579f7672021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98627-zhttps://doaj.org/toc/2045-2322Abstract We found the hepatic transcription factor Cyclic-AMP Responsive Element Binding Protein 3-like-3 (CREB3L3) to be expressed in adipose tissue, and selectively downregulated in the more metabolically protective subcutaneous adipose tissue in obese mice and humans. We sought to elucidate the specific role of this factor in adipose biology. CREB3L3 fat-specific knockout mice were fed a high-fat diet to induce obesity and metabolic dysfunction. Additionally, we injected a flip-excision adeno-associated virus directly into the subcutaneous inguinal adipose tissue of Adiponectin-Cre mice to create a depot-specific overexpression model for further assessment. Fat-specific ablation of CREB3L3 enhanced weight gain and insulin resistance following high-fat feeding, as fat-specific knockout mice expended less energy and possessed more inflammatory adipose tissue. Conversely, inguinal fat CREB3L3 overexpression deterred diet-induced obesity and ameliorated metabolic dysfunction. Together, this study highlights the relevance of CREB3L3 in obese adipose tissue and demonstrates its role as a powerful body weight modulator.Maximilian A. McCannYanliang LiMarcos MuñozVictoria GilGuifen QiangJose Cordoba-ChaconMatthias BlüherStephen DuncanChong Wee LiewNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maximilian A. McCann Yanliang Li Marcos Muñoz Victoria Gil Guifen Qiang Jose Cordoba-Chacon Matthias Blüher Stephen Duncan Chong Wee Liew Adipose expression of CREB3L3 modulates body weight during obesity
description	Abstract We found the hepatic transcription factor Cyclic-AMP Responsive Element Binding Protein 3-like-3 (CREB3L3) to be expressed in adipose tissue, and selectively downregulated in the more metabolically protective subcutaneous adipose tissue in obese mice and humans. We sought to elucidate the specific role of this factor in adipose biology. CREB3L3 fat-specific knockout mice were fed a high-fat diet to induce obesity and metabolic dysfunction. Additionally, we injected a flip-excision adeno-associated virus directly into the subcutaneous inguinal adipose tissue of Adiponectin-Cre mice to create a depot-specific overexpression model for further assessment. Fat-specific ablation of CREB3L3 enhanced weight gain and insulin resistance following high-fat feeding, as fat-specific knockout mice expended less energy and possessed more inflammatory adipose tissue. Conversely, inguinal fat CREB3L3 overexpression deterred diet-induced obesity and ameliorated metabolic dysfunction. Together, this study highlights the relevance of CREB3L3 in obese adipose tissue and demonstrates its role as a powerful body weight modulator.
format	article
author	Maximilian A. McCann Yanliang Li Marcos Muñoz Victoria Gil Guifen Qiang Jose Cordoba-Chacon Matthias Blüher Stephen Duncan Chong Wee Liew
author_facet	Maximilian A. McCann Yanliang Li Marcos Muñoz Victoria Gil Guifen Qiang Jose Cordoba-Chacon Matthias Blüher Stephen Duncan Chong Wee Liew
author_sort	Maximilian A. McCann
title	Adipose expression of CREB3L3 modulates body weight during obesity
title_short	Adipose expression of CREB3L3 modulates body weight during obesity
title_full	Adipose expression of CREB3L3 modulates body weight during obesity
title_fullStr	Adipose expression of CREB3L3 modulates body weight during obesity
title_full_unstemmed	Adipose expression of CREB3L3 modulates body weight during obesity
title_sort	adipose expression of creb3l3 modulates body weight during obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ba282b53acb742e59a203873b579f767
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Adipose expression of CREB3L3 modulates body weight during obesity

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