Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals

In 2012, the Council of Canadian Academies published the expert panel on integrated testing of pesticide’s report titled: Integrating emerging technologies into chemical safety assessment. This report was prepared for the Government of Canada in response to a request from the Minister of Health and...

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Autores principales:	Yadvinder Bhuller, Deborah Ramsingh, Marc Beal, Sunil Kulkarni, Matthew Gagne, Tara S Barton-Maclaren
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	next generation risk assessment integrated approach to testing and assessment adverse outcome pathways new approach methodologies weight of evidence Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doaj.org/article/ba2fabe2379c439c980cb35a1bd6e5d2
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id	oai:doaj.org-article:ba2fabe2379c439c980cb35a1bd6e5d2
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spelling	oai:doaj.org-article:ba2fabe2379c439c980cb35a1bd6e5d22021-11-04T06:57:18ZCanadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals2673-308010.3389/ftox.2021.748406https://doaj.org/article/ba2fabe2379c439c980cb35a1bd6e5d22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/ftox.2021.748406/fullhttps://doaj.org/toc/2673-3080In 2012, the Council of Canadian Academies published the expert panel on integrated testing of pesticide’s report titled: Integrating emerging technologies into chemical safety assessment. This report was prepared for the Government of Canada in response to a request from the Minister of Health and on behalf of the Pest Management Regulatory Agency. It examined the scientific status of the use of integrated testing strategies for the regulatory health risk assessment of pesticides while noting the data-rich/poor dichotomy that exists when comparing pesticide formulations to most industrial chemicals. It also noted that the adoption of integrated approaches to testing and assessment (IATA) strategies may refine and streamline testing of chemicals, as well as improve results in the future. Moreover, the experts expected to see an increase in the use of integrated testing strategies over the next decade, resulting in improved evidence-based decision-making. Subsequent to this report, there has been great advancements in IATA strategies, which includes the incorporation of adverse outcome pathways (AOPs) and new approach methodologies (NAMs). This perspective provides the first Canadian regulatory update on how Health Canada is also advancing the incorporation of alternative, non-animal strategies, using a weight of evidence approach, for the evaluation of pest control products and industrial chemicals. It will include specific initiatives and describe how this work is leading to the creation of next generation risk assessments. It also reflects Health Canada’s commitment towards implementing the 3Rs of animal testing: reduce, refine and replace the need for animal studies, whenever possible.Yadvinder BhullerDeborah RamsinghMarc BealSunil KulkarniMatthew GagneTara S Barton-MaclarenFrontiers Media S.A.articlenext generation risk assessmentintegrated approach to testing and assessmentadverse outcome pathwaysnew approach methodologiesweight of evidenceToxicology. PoisonsRA1190-1270ENFrontiers in Toxicology, Vol 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	next generation risk assessment integrated approach to testing and assessment adverse outcome pathways new approach methodologies weight of evidence Toxicology. Poisons RA1190-1270
spellingShingle	next generation risk assessment integrated approach to testing and assessment adverse outcome pathways new approach methodologies weight of evidence Toxicology. Poisons RA1190-1270 Yadvinder Bhuller Deborah Ramsingh Marc Beal Sunil Kulkarni Matthew Gagne Tara S Barton-Maclaren Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals
description	In 2012, the Council of Canadian Academies published the expert panel on integrated testing of pesticide’s report titled: Integrating emerging technologies into chemical safety assessment. This report was prepared for the Government of Canada in response to a request from the Minister of Health and on behalf of the Pest Management Regulatory Agency. It examined the scientific status of the use of integrated testing strategies for the regulatory health risk assessment of pesticides while noting the data-rich/poor dichotomy that exists when comparing pesticide formulations to most industrial chemicals. It also noted that the adoption of integrated approaches to testing and assessment (IATA) strategies may refine and streamline testing of chemicals, as well as improve results in the future. Moreover, the experts expected to see an increase in the use of integrated testing strategies over the next decade, resulting in improved evidence-based decision-making. Subsequent to this report, there has been great advancements in IATA strategies, which includes the incorporation of adverse outcome pathways (AOPs) and new approach methodologies (NAMs). This perspective provides the first Canadian regulatory update on how Health Canada is also advancing the incorporation of alternative, non-animal strategies, using a weight of evidence approach, for the evaluation of pest control products and industrial chemicals. It will include specific initiatives and describe how this work is leading to the creation of next generation risk assessments. It also reflects Health Canada’s commitment towards implementing the 3Rs of animal testing: reduce, refine and replace the need for animal studies, whenever possible.
format	article
author	Yadvinder Bhuller Deborah Ramsingh Marc Beal Sunil Kulkarni Matthew Gagne Tara S Barton-Maclaren
author_facet	Yadvinder Bhuller Deborah Ramsingh Marc Beal Sunil Kulkarni Matthew Gagne Tara S Barton-Maclaren
author_sort	Yadvinder Bhuller
title	Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals
title_short	Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals
title_full	Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals
title_fullStr	Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals
title_full_unstemmed	Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals
title_sort	canadian regulatory perspective on next generation risk assessments for pest control products and industrial chemicals
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ba2fabe2379c439c980cb35a1bd6e5d2
work_keys_str_mv	AT yadvinderbhuller canadianregulatoryperspectiveonnextgenerationriskassessmentsforpestcontrolproductsandindustrialchemicals AT deborahramsingh canadianregulatoryperspectiveonnextgenerationriskassessmentsforpestcontrolproductsandindustrialchemicals AT marcbeal canadianregulatoryperspectiveonnextgenerationriskassessmentsforpestcontrolproductsandindustrialchemicals AT sunilkulkarni canadianregulatoryperspectiveonnextgenerationriskassessmentsforpestcontrolproductsandindustrialchemicals AT matthewgagne canadianregulatoryperspectiveonnextgenerationriskassessmentsforpestcontrolproductsandindustrialchemicals AT tarasbartonmaclaren canadianregulatoryperspectiveonnextgenerationriskassessmentsforpestcontrolproductsandindustrialchemicals
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Canadian Regulatory Perspective on Next Generation Risk Assessments for Pest Control Products and Industrial Chemicals

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