Clinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma

Objective: To analyze the risk factors relative to postoperative psychiatric disorders in adult patients with craniopharyngioma.Methods: A retrospective case-control study design was used in this study. The Neuropsychiatric Inventory–Questionnaire (NPI-Q) assessment tool was used to assess psychiatr...

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Autores principales:	Rui Zhao, Pengwei Lu, Yanzhu Fan, Chuzhong Li, Chunhui Liu, Peng Zhao, Lei Cao, Hongwei Gao, Songbai Gui
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	craniopharyngioma psychiatric disorders risk factors hypothalamic invasion tumor location Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ba3073eeab414e628fc21f589dc5106e
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spelling	oai:doaj.org-article:ba3073eeab414e628fc21f589dc5106e2021-11-17T04:32:52ZClinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma1664-229510.3389/fneur.2021.754349https://doaj.org/article/ba3073eeab414e628fc21f589dc5106e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.754349/fullhttps://doaj.org/toc/1664-2295Objective: To analyze the risk factors relative to postoperative psychiatric disorders in adult patients with craniopharyngioma.Methods: A retrospective case-control study design was used in this study. The Neuropsychiatric Inventory–Questionnaire (NPI-Q) assessment tool was used to assess psychiatric disorders in postoperative patients with craniopharyngioma at Beijing Tiantan Hospital from January 2018 to December 2020. The relationship between the psychiatric disorders and basic demographic data as well as several risk factors, such as the tumor characteristics (tumor location, tumor size, pathological finding of the tumor, etc.) and treatment-related factors (the extent of the resection), were analyzed.Results: A total of 173 patients were included in this study. The prevalence of psychiatric disorders was 14.5% among adult craniopharyngioma patients. Irritability represented the most common type of psychological symptom (64%, n = 16), followed by agitation (36%, n = 9), and delusions (28%, n = 7). The risk factors relative to postoperative psychiatric disorders that were identified were a tumor volume larger than 7 cm3 (HR = 3.292, P = 0.042), tumor location (P = 0.003), hypothalamic invasion (HR = 9.766, P = 0.036), and gross-total resection (HR = 0.085, P = 0.042).Conclusion: Neurocognitive assessment and intervention before and after surgery are important in patients with larger tumors, invading the third ventricle, and tumors with hypothalamic invasion. Prediction of these risk factors is essential for the treatment.Rui ZhaoPengwei LuYanzhu FanChuzhong LiChunhui LiuPeng ZhaoLei CaoHongwei GaoSongbai GuiFrontiers Media S.A.articlecraniopharyngiomapsychiatric disordersrisk factorshypothalamic invasiontumor locationNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	craniopharyngioma psychiatric disorders risk factors hypothalamic invasion tumor location Neurology. Diseases of the nervous system RC346-429
spellingShingle	craniopharyngioma psychiatric disorders risk factors hypothalamic invasion tumor location Neurology. Diseases of the nervous system RC346-429 Rui Zhao Pengwei Lu Yanzhu Fan Chuzhong Li Chunhui Liu Peng Zhao Lei Cao Hongwei Gao Songbai Gui Clinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma
description	Objective: To analyze the risk factors relative to postoperative psychiatric disorders in adult patients with craniopharyngioma.Methods: A retrospective case-control study design was used in this study. The Neuropsychiatric Inventory–Questionnaire (NPI-Q) assessment tool was used to assess psychiatric disorders in postoperative patients with craniopharyngioma at Beijing Tiantan Hospital from January 2018 to December 2020. The relationship between the psychiatric disorders and basic demographic data as well as several risk factors, such as the tumor characteristics (tumor location, tumor size, pathological finding of the tumor, etc.) and treatment-related factors (the extent of the resection), were analyzed.Results: A total of 173 patients were included in this study. The prevalence of psychiatric disorders was 14.5% among adult craniopharyngioma patients. Irritability represented the most common type of psychological symptom (64%, n = 16), followed by agitation (36%, n = 9), and delusions (28%, n = 7). The risk factors relative to postoperative psychiatric disorders that were identified were a tumor volume larger than 7 cm3 (HR = 3.292, P = 0.042), tumor location (P = 0.003), hypothalamic invasion (HR = 9.766, P = 0.036), and gross-total resection (HR = 0.085, P = 0.042).Conclusion: Neurocognitive assessment and intervention before and after surgery are important in patients with larger tumors, invading the third ventricle, and tumors with hypothalamic invasion. Prediction of these risk factors is essential for the treatment.
format	article
author	Rui Zhao Pengwei Lu Yanzhu Fan Chuzhong Li Chunhui Liu Peng Zhao Lei Cao Hongwei Gao Songbai Gui
author_facet	Rui Zhao Pengwei Lu Yanzhu Fan Chuzhong Li Chunhui Liu Peng Zhao Lei Cao Hongwei Gao Songbai Gui
author_sort	Rui Zhao
title	Clinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma
title_short	Clinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma
title_full	Clinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma
title_fullStr	Clinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma
title_full_unstemmed	Clinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma
title_sort	clinical analysis of risk factors of postoperative psychiatric disorders in patients with adult craniopharyngioma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ba3073eeab414e628fc21f589dc5106e
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Clinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma

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