Contribution of miRNAs in the Pathogenesis of Breast Cancer

Breast cancer is the most frequently diagnosed cancer among females. Gene expression profiling methods have shown the deregulation of several genes in breast cancer samples and have confirmed the heterogeneous nature of breast cancer at the genomic level. microRNAs (miRNAs) are among the recently ap...

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Autores principales:	Soudeh Ghafouri-Fard, Ali Khanbabapour Sasi, Atefe Abak, Hamed Shoorei, Ali Khoshkar, Mohammad Taheri
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	miRNA microRNA breast cancer apoptosis biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ba30913c8b824828a4fe41829cb15fdc
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spelling	oai:doaj.org-article:ba30913c8b824828a4fe41829cb15fdc2021-11-05T07:51:14ZContribution of miRNAs in the Pathogenesis of Breast Cancer2234-943X10.3389/fonc.2021.768949https://doaj.org/article/ba30913c8b824828a4fe41829cb15fdc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.768949/fullhttps://doaj.org/toc/2234-943XBreast cancer is the most frequently diagnosed cancer among females. Gene expression profiling methods have shown the deregulation of several genes in breast cancer samples and have confirmed the heterogeneous nature of breast cancer at the genomic level. microRNAs (miRNAs) are among the recently appreciated contributors in breast carcinogenic processes. These small-sized transcripts have been shown to partake in breast carcinogenesis through modulation of apoptosis, autophagy, and epithelial–mesenchymal transition. Moreover, they can confer resistance to chemotherapy. Based on the contribution of miRNAs in almost all fundamental aspects of breast carcinogenesis, therapeutic intervention with their expression might affect the course of this disorder. Moreover, the presence of miRNAs in the peripheral blood of patients potentiates these transcripts as tools for non-invasive diagnosis of breast cancer.Soudeh Ghafouri-FardAli Khanbabapour SasiAtefe AbakHamed ShooreiAli KhoshkarMohammad TaheriFrontiers Media S.A.articlemiRNAmicroRNAbreast cancerapoptosisbiomarkerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miRNA microRNA breast cancer apoptosis biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	miRNA microRNA breast cancer apoptosis biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Soudeh Ghafouri-Fard Ali Khanbabapour Sasi Atefe Abak Hamed Shoorei Ali Khoshkar Mohammad Taheri Contribution of miRNAs in the Pathogenesis of Breast Cancer
description	Breast cancer is the most frequently diagnosed cancer among females. Gene expression profiling methods have shown the deregulation of several genes in breast cancer samples and have confirmed the heterogeneous nature of breast cancer at the genomic level. microRNAs (miRNAs) are among the recently appreciated contributors in breast carcinogenic processes. These small-sized transcripts have been shown to partake in breast carcinogenesis through modulation of apoptosis, autophagy, and epithelial–mesenchymal transition. Moreover, they can confer resistance to chemotherapy. Based on the contribution of miRNAs in almost all fundamental aspects of breast carcinogenesis, therapeutic intervention with their expression might affect the course of this disorder. Moreover, the presence of miRNAs in the peripheral blood of patients potentiates these transcripts as tools for non-invasive diagnosis of breast cancer.
format	article
author	Soudeh Ghafouri-Fard Ali Khanbabapour Sasi Atefe Abak Hamed Shoorei Ali Khoshkar Mohammad Taheri
author_facet	Soudeh Ghafouri-Fard Ali Khanbabapour Sasi Atefe Abak Hamed Shoorei Ali Khoshkar Mohammad Taheri
author_sort	Soudeh Ghafouri-Fard
title	Contribution of miRNAs in the Pathogenesis of Breast Cancer
title_short	Contribution of miRNAs in the Pathogenesis of Breast Cancer
title_full	Contribution of miRNAs in the Pathogenesis of Breast Cancer
title_fullStr	Contribution of miRNAs in the Pathogenesis of Breast Cancer
title_full_unstemmed	Contribution of miRNAs in the Pathogenesis of Breast Cancer
title_sort	contribution of mirnas in the pathogenesis of breast cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ba30913c8b824828a4fe41829cb15fdc
work_keys_str_mv	AT soudehghafourifard contributionofmirnasinthepathogenesisofbreastcancer AT alikhanbabapoursasi contributionofmirnasinthepathogenesisofbreastcancer AT atefeabak contributionofmirnasinthepathogenesisofbreastcancer AT hamedshoorei contributionofmirnasinthepathogenesisofbreastcancer AT alikhoshkar contributionofmirnasinthepathogenesisofbreastcancer AT mohammadtaheri contributionofmirnasinthepathogenesisofbreastcancer
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Contribution of miRNAs in the Pathogenesis of Breast Cancer

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