Arrhythmogenic Remodeling in the Failing Heart

Chronic heart failure is a clinical syndrome with multiple etiologies, associated with significant morbidity and mortality. Cardiac arrhythmias, including ventricular tachyarrhythmias and atrial fibrillation, are common in heart failure. A number of cardiac diseases including heart failure alter the...

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Autores principales:	Zoltán Husti, András Varró, István Baczkó
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arrhythmias atrial fibrillation calcium handling heart failure remodeling potassium currents Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ba32c89abe414be6ab1312a6d7dc7023
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spelling	oai:doaj.org-article:ba32c89abe414be6ab1312a6d7dc70232021-11-25T17:12:50ZArrhythmogenic Remodeling in the Failing Heart10.3390/cells101132032073-4409https://doaj.org/article/ba32c89abe414be6ab1312a6d7dc70232021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3203https://doaj.org/toc/2073-4409Chronic heart failure is a clinical syndrome with multiple etiologies, associated with significant morbidity and mortality. Cardiac arrhythmias, including ventricular tachyarrhythmias and atrial fibrillation, are common in heart failure. A number of cardiac diseases including heart failure alter the expression and regulation of ion channels and transporters leading to arrhythmogenic electrical remodeling. Myocardial hypertrophy, fibrosis and scar formation are key elements of arrhythmogenic structural remodeling in heart failure. In this article, the mechanisms responsible for increased arrhythmia susceptibility as well as the underlying changes in ion channel, transporter expression and function as well as alterations in calcium handling in heart failure are discussed. Understanding the mechanisms of arrhythmogenic remodeling is key to improving arrhythmia management and the prevention of sudden cardiac death in patients with heart failure.Zoltán HustiAndrás VarróIstván BaczkóMDPI AGarticlearrhythmiasatrial fibrillationcalcium handlingheart failureremodelingpotassium currentsBiology (General)QH301-705.5ENCells, Vol 10, Iss 3203, p 3203 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arrhythmias atrial fibrillation calcium handling heart failure remodeling potassium currents Biology (General) QH301-705.5
spellingShingle	arrhythmias atrial fibrillation calcium handling heart failure remodeling potassium currents Biology (General) QH301-705.5 Zoltán Husti András Varró István Baczkó Arrhythmogenic Remodeling in the Failing Heart
description	Chronic heart failure is a clinical syndrome with multiple etiologies, associated with significant morbidity and mortality. Cardiac arrhythmias, including ventricular tachyarrhythmias and atrial fibrillation, are common in heart failure. A number of cardiac diseases including heart failure alter the expression and regulation of ion channels and transporters leading to arrhythmogenic electrical remodeling. Myocardial hypertrophy, fibrosis and scar formation are key elements of arrhythmogenic structural remodeling in heart failure. In this article, the mechanisms responsible for increased arrhythmia susceptibility as well as the underlying changes in ion channel, transporter expression and function as well as alterations in calcium handling in heart failure are discussed. Understanding the mechanisms of arrhythmogenic remodeling is key to improving arrhythmia management and the prevention of sudden cardiac death in patients with heart failure.
format	article
author	Zoltán Husti András Varró István Baczkó
author_facet	Zoltán Husti András Varró István Baczkó
author_sort	Zoltán Husti
title	Arrhythmogenic Remodeling in the Failing Heart
title_short	Arrhythmogenic Remodeling in the Failing Heart
title_full	Arrhythmogenic Remodeling in the Failing Heart
title_fullStr	Arrhythmogenic Remodeling in the Failing Heart
title_full_unstemmed	Arrhythmogenic Remodeling in the Failing Heart
title_sort	arrhythmogenic remodeling in the failing heart
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ba32c89abe414be6ab1312a6d7dc7023
work_keys_str_mv	AT zoltanhusti arrhythmogenicremodelinginthefailingheart AT andrasvarro arrhythmogenicremodelinginthefailingheart AT istvanbaczko arrhythmogenicremodelinginthefailingheart
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Arrhythmogenic Remodeling in the Failing Heart

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