Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice

Yanjie Yang,1 Shuangyu Lv,1 Fengling Wang,1 Yang An,1 Na Fang,1 Weijuan Zhang,1 Wei Zhao,1 Xiangqian Guo,1 Shaoping Ji1,21School of Basic Medical Sciences, Henan University, Kaifeng 475004, People’s Republic of China; 2Henan Provincial Engineering Centre of Tumor Molecular Diagnosis and Th...

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Autores principales:	Yang Y, Lv S, Wang F, An Y, Fang N, Zhang W, Zhao W, Guo X, Ji S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Mn-doped ZnS QDs toxicity metabolomics GC-MS mice Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ba36f0827e1246f3884081ad9e0de661
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spelling	oai:doaj.org-article:ba36f0827e1246f3884081ad9e0de6612021-12-02T03:53:48ZToxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice1178-2013https://doaj.org/article/ba36f0827e1246f3884081ad9e0de6612019-08-01T00:00:00Zhttps://www.dovepress.com/toxicity-and-serum-metabolomics-investigation-of-mn-doped-zns-quantum--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yanjie Yang,1 Shuangyu Lv,1 Fengling Wang,1 Yang An,1 Na Fang,1 Weijuan Zhang,1 Wei Zhao,1 Xiangqian Guo,1 Shaoping Ji1,21School of Basic Medical Sciences, Henan University, Kaifeng 475004, People’s Republic of China; 2Henan Provincial Engineering Centre of Tumor Molecular Diagnosis and Therapy & Kaifeng Municipal Key Laboratory of Cell Signal Transduction, Henan University, Kaifeng 475004, People’s Republic of ChinaPurpose: Mn-doped ZnS quantum dots (QDs) with special luminescent properties have been widely researched and applied in various fields. Thus, their release toxicity and security cannot be ignored.Methods: In the present study, the toxicity and non-targeted metabolomics of Mn-doped ZnS QDs were investigated after single intravenous injection. Serum metabolites were evaluated based on gas chromatography–mass spectrometry together with multivariate statistical analyses [principal component analysis, partial least squares discriminant analysis, and orthogonal PLS-DA].Results: The modified metabolites (variable importance in the projection (VIP) >1 and p<0.05) revealed that Mn-doped ZnS QDs exposure disturbed glycolysis, tricarboxylic acid cycle, ketoplasia, glutaminolysis, and amino acid and lipid metabolism. The behavior, coefficients of organs, and histological changes were the same as in the control group, and the disturbance of hematology and serum biochemistry was not dose- or time-dependent.Conclusion: Our study provides a general observation regarding the toxicity and potential metabolic responses of mice exposed to Mn-doped ZnS QDs.Keywords: Mn-doped ZnS QDs, toxicity, metabolomics, GC-MS, miceYang YLv SWang FAn YFang NZhang WZhao WGuo XJi SDove Medical PressarticleMn-doped ZnS QDstoxicitymetabolomicsGC-MSmiceMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 6297-6311 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mn-doped ZnS QDs toxicity metabolomics GC-MS mice Medicine (General) R5-920
spellingShingle	Mn-doped ZnS QDs toxicity metabolomics GC-MS mice Medicine (General) R5-920 Yang Y Lv S Wang F An Y Fang N Zhang W Zhao W Guo X Ji S Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
description	Yanjie Yang,1 Shuangyu Lv,1 Fengling Wang,1 Yang An,1 Na Fang,1 Weijuan Zhang,1 Wei Zhao,1 Xiangqian Guo,1 Shaoping Ji1,21School of Basic Medical Sciences, Henan University, Kaifeng 475004, People’s Republic of China; 2Henan Provincial Engineering Centre of Tumor Molecular Diagnosis and Therapy & Kaifeng Municipal Key Laboratory of Cell Signal Transduction, Henan University, Kaifeng 475004, People’s Republic of ChinaPurpose: Mn-doped ZnS quantum dots (QDs) with special luminescent properties have been widely researched and applied in various fields. Thus, their release toxicity and security cannot be ignored.Methods: In the present study, the toxicity and non-targeted metabolomics of Mn-doped ZnS QDs were investigated after single intravenous injection. Serum metabolites were evaluated based on gas chromatography–mass spectrometry together with multivariate statistical analyses [principal component analysis, partial least squares discriminant analysis, and orthogonal PLS-DA].Results: The modified metabolites (variable importance in the projection (VIP) >1 and p<0.05) revealed that Mn-doped ZnS QDs exposure disturbed glycolysis, tricarboxylic acid cycle, ketoplasia, glutaminolysis, and amino acid and lipid metabolism. The behavior, coefficients of organs, and histological changes were the same as in the control group, and the disturbance of hematology and serum biochemistry was not dose- or time-dependent.Conclusion: Our study provides a general observation regarding the toxicity and potential metabolic responses of mice exposed to Mn-doped ZnS QDs.Keywords: Mn-doped ZnS QDs, toxicity, metabolomics, GC-MS, mice
format	article
author	Yang Y Lv S Wang F An Y Fang N Zhang W Zhao W Guo X Ji S
author_facet	Yang Y Lv S Wang F An Y Fang N Zhang W Zhao W Guo X Ji S
author_sort	Yang Y
title	Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_short	Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_full	Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_fullStr	Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_full_unstemmed	Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice
title_sort	toxicity and serum metabolomics investigation of mn-doped zns quantum dots in mice
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/ba36f0827e1246f3884081ad9e0de661
work_keys_str_mv	AT yangy toxicityandserummetabolomicsinvestigationofmndopedznsquantumdotsinmice AT lvs toxicityandserummetabolomicsinvestigationofmndopedznsquantumdotsinmice AT wangf toxicityandserummetabolomicsinvestigationofmndopedznsquantumdotsinmice AT any toxicityandserummetabolomicsinvestigationofmndopedznsquantumdotsinmice AT fangn toxicityandserummetabolomicsinvestigationofmndopedznsquantumdotsinmice AT zhangw toxicityandserummetabolomicsinvestigationofmndopedznsquantumdotsinmice AT zhaow toxicityandserummetabolomicsinvestigationofmndopedznsquantumdotsinmice AT guox toxicityandserummetabolomicsinvestigationofmndopedznsquantumdotsinmice AT jis toxicityandserummetabolomicsinvestigationofmndopedznsquantumdotsinmice
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Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice

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