The free energy landscape of retroviral integration

Retroviral integration of DNA into the host genome is a point of no return in the replication cycle but how efficient integration can take place remains unclear. Here the authors demonstrate that consecutive nucleoprotein intermediates are increasingly stable, resulting in a net forward rate.

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Autores principales:	Willem Vanderlinden, Tine Brouns, Philipp U. Walker, Pauline J. Kolbeck, Lukas F. Milles, Wolfgang Ott, Philipp C. Nickels, Zeger Debyser, Jan Lipfert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ba3ac588e06f42a0baa99862c45b98ff
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spelling	oai:doaj.org-article:ba3ac588e06f42a0baa99862c45b98ff2021-12-02T17:02:11ZThe free energy landscape of retroviral integration10.1038/s41467-019-12649-w2041-1723https://doaj.org/article/ba3ac588e06f42a0baa99862c45b98ff2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12649-whttps://doaj.org/toc/2041-1723Retroviral integration of DNA into the host genome is a point of no return in the replication cycle but how efficient integration can take place remains unclear. Here the authors demonstrate that consecutive nucleoprotein intermediates are increasingly stable, resulting in a net forward rate.Willem VanderlindenTine BrounsPhilipp U. WalkerPauline J. KolbeckLukas F. MillesWolfgang OttPhilipp C. NickelsZeger DebyserJan LipfertNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Willem Vanderlinden Tine Brouns Philipp U. Walker Pauline J. Kolbeck Lukas F. Milles Wolfgang Ott Philipp C. Nickels Zeger Debyser Jan Lipfert The free energy landscape of retroviral integration
description	Retroviral integration of DNA into the host genome is a point of no return in the replication cycle but how efficient integration can take place remains unclear. Here the authors demonstrate that consecutive nucleoprotein intermediates are increasingly stable, resulting in a net forward rate.
format	article
author	Willem Vanderlinden Tine Brouns Philipp U. Walker Pauline J. Kolbeck Lukas F. Milles Wolfgang Ott Philipp C. Nickels Zeger Debyser Jan Lipfert
author_facet	Willem Vanderlinden Tine Brouns Philipp U. Walker Pauline J. Kolbeck Lukas F. Milles Wolfgang Ott Philipp C. Nickels Zeger Debyser Jan Lipfert
author_sort	Willem Vanderlinden
title	The free energy landscape of retroviral integration
title_short	The free energy landscape of retroviral integration
title_full	The free energy landscape of retroviral integration
title_fullStr	The free energy landscape of retroviral integration
title_full_unstemmed	The free energy landscape of retroviral integration
title_sort	free energy landscape of retroviral integration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ba3ac588e06f42a0baa99862c45b98ff
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The free energy landscape of retroviral integration

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