Histopathological characteristics of cervical extensor tissue in patients with dropped head syndrome

Abstract Background To date, the histopathologic characteristics of dropped head syndrome (DHS) have not been reported sufficiently. The present study investigates the histopathology of biopsy specimens from the cervical paravertebral region in patients with DHS. Methods Histopathological parameters...

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Autores principales:	Kenji Endo, Jun Matsubayashi, Yasunobu Sawaji, Kazuma Murata, Takamitsu Konishi, Toshitaka Nagao, Kengo Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Dropped head syndrome Histopathological characteristics Cervical paravertebral region Skeletal muscle Necrosis, microvessel proliferation Atrophy Medicine R
Acceso en línea:	https://doaj.org/article/ba3b3f20c335451cb6c087ebadbc456c
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spelling	oai:doaj.org-article:ba3b3f20c335451cb6c087ebadbc456c2021-11-28T12:23:41ZHistopathological characteristics of cervical extensor tissue in patients with dropped head syndrome10.1186/s40001-021-00605-82047-783Xhttps://doaj.org/article/ba3b3f20c335451cb6c087ebadbc456c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40001-021-00605-8https://doaj.org/toc/2047-783XAbstract Background To date, the histopathologic characteristics of dropped head syndrome (DHS) have not been reported sufficiently. The present study investigates the histopathology of biopsy specimens from the cervical paravertebral region in patients with DHS. Methods Histopathological parameters were evaluated in biopsy specimens of the cervical paravertebral soft tissue from 15 patients with DHS. Results Among the 15 cases of DHS examined, skeletal muscle was identified in 7 cases, all of which showed necrosis, microvessel proliferation and atrophy. The ligament was identified in 12 cases, 8 of which showed degeneration. The lag time between the onset of symptoms and the performance of a biopsy in all 8 cases, which showed degeneration was over 3 months. Microvessel proliferation in the ligament was observed in 1 of the 4 cases, in which the lag time between the onset of symptoms and the performance of a biopsy was less than 3 months (acute or subacute phase), and in 7 of the 8 cases, in which the lag time between the symptoms and the performance of a biopsy was over 3 months (chronic phase). Chronic inflammation in the ligament was identified in 1 of the 12 cases. Conclusions The identification of necrosis, microvessel proliferation, and atrophy in the skeletal muscle of patients with DHS and the presence of ligament degeneration and microvessel proliferation in the chronic but not acute or subacute phases may suggest that persistent skeletal muscle damage of the cervical paravertebral region causes subsequent ligament damage in patients with DHS.Kenji EndoJun MatsubayashiYasunobu SawajiKazuma MurataTakamitsu KonishiToshitaka NagaoKengo YamamotoBMCarticleDropped head syndromeHistopathological characteristicsCervical paravertebral regionSkeletal muscleNecrosis, microvessel proliferationAtrophyMedicineRENEuropean Journal of Medical Research, Vol 26, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dropped head syndrome Histopathological characteristics Cervical paravertebral region Skeletal muscle Necrosis, microvessel proliferation Atrophy Medicine R
spellingShingle	Dropped head syndrome Histopathological characteristics Cervical paravertebral region Skeletal muscle Necrosis, microvessel proliferation Atrophy Medicine R Kenji Endo Jun Matsubayashi Yasunobu Sawaji Kazuma Murata Takamitsu Konishi Toshitaka Nagao Kengo Yamamoto Histopathological characteristics of cervical extensor tissue in patients with dropped head syndrome
description	Abstract Background To date, the histopathologic characteristics of dropped head syndrome (DHS) have not been reported sufficiently. The present study investigates the histopathology of biopsy specimens from the cervical paravertebral region in patients with DHS. Methods Histopathological parameters were evaluated in biopsy specimens of the cervical paravertebral soft tissue from 15 patients with DHS. Results Among the 15 cases of DHS examined, skeletal muscle was identified in 7 cases, all of which showed necrosis, microvessel proliferation and atrophy. The ligament was identified in 12 cases, 8 of which showed degeneration. The lag time between the onset of symptoms and the performance of a biopsy in all 8 cases, which showed degeneration was over 3 months. Microvessel proliferation in the ligament was observed in 1 of the 4 cases, in which the lag time between the onset of symptoms and the performance of a biopsy was less than 3 months (acute or subacute phase), and in 7 of the 8 cases, in which the lag time between the symptoms and the performance of a biopsy was over 3 months (chronic phase). Chronic inflammation in the ligament was identified in 1 of the 12 cases. Conclusions The identification of necrosis, microvessel proliferation, and atrophy in the skeletal muscle of patients with DHS and the presence of ligament degeneration and microvessel proliferation in the chronic but not acute or subacute phases may suggest that persistent skeletal muscle damage of the cervical paravertebral region causes subsequent ligament damage in patients with DHS.
format	article
author	Kenji Endo Jun Matsubayashi Yasunobu Sawaji Kazuma Murata Takamitsu Konishi Toshitaka Nagao Kengo Yamamoto
author_facet	Kenji Endo Jun Matsubayashi Yasunobu Sawaji Kazuma Murata Takamitsu Konishi Toshitaka Nagao Kengo Yamamoto
author_sort	Kenji Endo
title	Histopathological characteristics of cervical extensor tissue in patients with dropped head syndrome
title_short	Histopathological characteristics of cervical extensor tissue in patients with dropped head syndrome
title_full	Histopathological characteristics of cervical extensor tissue in patients with dropped head syndrome
title_fullStr	Histopathological characteristics of cervical extensor tissue in patients with dropped head syndrome
title_full_unstemmed	Histopathological characteristics of cervical extensor tissue in patients with dropped head syndrome
title_sort	histopathological characteristics of cervical extensor tissue in patients with dropped head syndrome
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ba3b3f20c335451cb6c087ebadbc456c
work_keys_str_mv	AT kenjiendo histopathologicalcharacteristicsofcervicalextensortissueinpatientswithdroppedheadsyndrome AT junmatsubayashi histopathologicalcharacteristicsofcervicalextensortissueinpatientswithdroppedheadsyndrome AT yasunobusawaji histopathologicalcharacteristicsofcervicalextensortissueinpatientswithdroppedheadsyndrome AT kazumamurata histopathologicalcharacteristicsofcervicalextensortissueinpatientswithdroppedheadsyndrome AT takamitsukonishi histopathologicalcharacteristicsofcervicalextensortissueinpatientswithdroppedheadsyndrome AT toshitakanagao histopathologicalcharacteristicsofcervicalextensortissueinpatientswithdroppedheadsyndrome AT kengoyamamoto histopathologicalcharacteristicsofcervicalextensortissueinpatientswithdroppedheadsyndrome
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Histopathological characteristics of cervical extensor tissue in patients with dropped head syndrome

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