Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection

The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It has affected every aspect of life and increased the burden on both healthcare and socioeconomic systems. Current studies have reve...

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Autores principales:	Hi Eun Jung, Heung Kyu Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 Toll-like receptor (TLR) cytokine storm hyperinflammation Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ba4262cae7134e4689dc32de7dd8091b
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spelling	oai:doaj.org-article:ba4262cae7134e4689dc32de7dd8091b2021-11-25T19:12:33ZCurrent Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection10.3390/v131121321999-4915https://doaj.org/article/ba4262cae7134e4689dc32de7dd8091b2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2132https://doaj.org/toc/1999-4915The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It has affected every aspect of life and increased the burden on both healthcare and socioeconomic systems. Current studies have revealed that excessive inflammatory immune responses are responsible for the severity of COVID-19, which suggests that anti-inflammatory drugs may be promising therapeutic treatments. However, there are currently a limited number of approved therapeutics for COVID-19. Toll-like receptors (TLRs), which recognize microbial components derived from invading pathogens, are involved in both the initiation of innate responses against SARS-CoV-2 infection and the hyperinflammatory phenotype of COVID-19. In this review, we provide current knowledge on the pivotal role of TLRs in immune responses against SARS-CoV-2 infection and demonstrate the potential effectiveness of TLR-targeting drugs on the control of hyperinflammation in patients with COVID-19.Hi Eun JungHeung Kyu LeeMDPI AGarticleSARS-CoV-2COVID-19Toll-like receptor (TLR)cytokine stormhyperinflammationMicrobiologyQR1-502ENViruses, Vol 13, Iss 2132, p 2132 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 Toll-like receptor (TLR) cytokine storm hyperinflammation Microbiology QR1-502
spellingShingle	SARS-CoV-2 COVID-19 Toll-like receptor (TLR) cytokine storm hyperinflammation Microbiology QR1-502 Hi Eun Jung Heung Kyu Lee Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection
description	The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It has affected every aspect of life and increased the burden on both healthcare and socioeconomic systems. Current studies have revealed that excessive inflammatory immune responses are responsible for the severity of COVID-19, which suggests that anti-inflammatory drugs may be promising therapeutic treatments. However, there are currently a limited number of approved therapeutics for COVID-19. Toll-like receptors (TLRs), which recognize microbial components derived from invading pathogens, are involved in both the initiation of innate responses against SARS-CoV-2 infection and the hyperinflammatory phenotype of COVID-19. In this review, we provide current knowledge on the pivotal role of TLRs in immune responses against SARS-CoV-2 infection and demonstrate the potential effectiveness of TLR-targeting drugs on the control of hyperinflammation in patients with COVID-19.
format	article
author	Hi Eun Jung Heung Kyu Lee
author_facet	Hi Eun Jung Heung Kyu Lee
author_sort	Hi Eun Jung
title	Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection
title_short	Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection
title_full	Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection
title_fullStr	Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection
title_full_unstemmed	Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection
title_sort	current understanding of the innate control of toll-like receptors in response to sars-cov-2 infection
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ba4262cae7134e4689dc32de7dd8091b
work_keys_str_mv	AT hieunjung currentunderstandingoftheinnatecontroloftolllikereceptorsinresponsetosarscov2infection AT heungkyulee currentunderstandingoftheinnatecontroloftolllikereceptorsinresponsetosarscov2infection
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Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection

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