Top-down beta rhythms support selective attention via interlaminar interaction: a model.

Cortical rhythms have been thought to play crucial roles in our cognitive abilities. Rhythmic activity in the beta frequency band, around 20 Hz, has been reported in recent studies that focused on neural correlates of attention, indicating that top-down beta rhythms, generated in higher cognitive ar...

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Autores principales:	Jung H Lee, Miles A Whittington, Nancy J Kopell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ba47d188b72044759bd6fbf528f80d2d
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id	oai:doaj.org-article:ba47d188b72044759bd6fbf528f80d2d
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spelling	oai:doaj.org-article:ba47d188b72044759bd6fbf528f80d2d2021-11-18T05:53:41ZTop-down beta rhythms support selective attention via interlaminar interaction: a model.1553-734X1553-735810.1371/journal.pcbi.1003164https://doaj.org/article/ba47d188b72044759bd6fbf528f80d2d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23950699/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Cortical rhythms have been thought to play crucial roles in our cognitive abilities. Rhythmic activity in the beta frequency band, around 20 Hz, has been reported in recent studies that focused on neural correlates of attention, indicating that top-down beta rhythms, generated in higher cognitive areas and delivered to earlier sensory areas, can support attentional gain modulation. To elucidate functional roles of beta rhythms and underlying mechanisms, we built a computational model of sensory cortical areas. Our simulation results show that top-down beta rhythms can activate ascending synaptic projections from L5 to L4 and L2/3, responsible for biased competition in superficial layers. In the simulation, slow-inhibitory interneurons are shown to resonate to the 20 Hz input and modulate the activity in superficial layers in an attention-related manner. The predicted critical roles of these cells in attentional gain provide a potential mechanism by which cholinergic drive can support selective attention.Jung H LeeMiles A WhittingtonNancy J KopellPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 8, p e1003164 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jung H Lee Miles A Whittington Nancy J Kopell Top-down beta rhythms support selective attention via interlaminar interaction: a model.
description	Cortical rhythms have been thought to play crucial roles in our cognitive abilities. Rhythmic activity in the beta frequency band, around 20 Hz, has been reported in recent studies that focused on neural correlates of attention, indicating that top-down beta rhythms, generated in higher cognitive areas and delivered to earlier sensory areas, can support attentional gain modulation. To elucidate functional roles of beta rhythms and underlying mechanisms, we built a computational model of sensory cortical areas. Our simulation results show that top-down beta rhythms can activate ascending synaptic projections from L5 to L4 and L2/3, responsible for biased competition in superficial layers. In the simulation, slow-inhibitory interneurons are shown to resonate to the 20 Hz input and modulate the activity in superficial layers in an attention-related manner. The predicted critical roles of these cells in attentional gain provide a potential mechanism by which cholinergic drive can support selective attention.
format	article
author	Jung H Lee Miles A Whittington Nancy J Kopell
author_facet	Jung H Lee Miles A Whittington Nancy J Kopell
author_sort	Jung H Lee
title	Top-down beta rhythms support selective attention via interlaminar interaction: a model.
title_short	Top-down beta rhythms support selective attention via interlaminar interaction: a model.
title_full	Top-down beta rhythms support selective attention via interlaminar interaction: a model.
title_fullStr	Top-down beta rhythms support selective attention via interlaminar interaction: a model.
title_full_unstemmed	Top-down beta rhythms support selective attention via interlaminar interaction: a model.
title_sort	top-down beta rhythms support selective attention via interlaminar interaction: a model.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ba47d188b72044759bd6fbf528f80d2d
work_keys_str_mv	AT junghlee topdownbetarhythmssupportselectiveattentionviainterlaminarinteractionamodel AT milesawhittington topdownbetarhythmssupportselectiveattentionviainterlaminarinteractionamodel AT nancyjkopell topdownbetarhythmssupportselectiveattentionviainterlaminarinteractionamodel
_version_	1718424689780457472

Top-down beta rhythms support selective attention via interlaminar interaction: a model.

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